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TargetEpidermal growth factor receptor(Human)
Harvard Medical School

LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataKd:  35.3nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Harvard Medical School

LigandPNGBDBM26105(6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...)
Affinity DataKd:  5.30nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [696-1022,T790M](Human)
Harvard Medical School

LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataKd:  4.60nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [696-1022,T790M](Human)
Harvard Medical School

LigandPNGBDBM26105(6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...)
Affinity DataKd:  27.6nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [696-1022,L858R](Human)
Harvard Medical School

LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataKd:  2.40nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [696-1022,L858R](Human)
Harvard Medical School

LigandPNGBDBM26105(6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...)
Affinity DataKd:  1.10nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2008
Entry Details Article
PubMed
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataKd:  10.9nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM26105(6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...)
Affinity DataKd:  18.6nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2008
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM423689(US10508120, Compound I-144 | US10577373, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424808(US10508120, Compound I-1413 | US10508120, Compound...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424807(US10508120, Compound I-1311 | US10577373, Compound...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM565754(US11414431, Compound I-322)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50618788(CHEMBL5427213)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424408(US10508120, Compound I-904 | US10508120, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424450(US10508120, Compound I-905 | US10577373, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424408(US10508120, Compound I-904 | US10508120, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424220(US10508120, Compound I-675 | US10508120, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424321(US10508120, Compound I-776 | US10577373, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424111(US10508120, Compound I-572 | US10577373, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424118(US10577373, Compound I-573 | US10508120, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM565847(US11414431, Compound I-415)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424040(US10577373, Compound I-495 | US10508120, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM565510(US11414431, Compound I-76)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM565511(US11414431, Compound I-77)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424086(US10577373, Compound I-541 | US10508120, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM423689(US10508120, Compound I-144 | US10577373, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424808(US10508120, Compound I-1413 | US10508120, Compound...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424807(US10508120, Compound I-1311 | US10577373, Compound...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM565754(US11414431, Compound I-322)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50618788(CHEMBL5427213)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424408(US10508120, Compound I-904 | US10508120, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424450(US10508120, Compound I-905 | US10577373, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424408(US10508120, Compound I-904 | US10508120, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424220(US10508120, Compound I-675 | US10508120, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424321(US10508120, Compound I-776 | US10577373, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424111(US10508120, Compound I-572 | US10577373, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424118(US10577373, Compound I-573 | US10508120, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM565847(US11414431, Compound I-415)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424040(US10577373, Compound I-495 | US10508120, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM565510(US11414431, Compound I-76)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM565511(US11414431, Compound I-77)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424086(US10577373, Compound I-541 | US10508120, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM435794(US10577373, Compound I-954)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK3 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM423689(US10508120, Compound I-144 | US10577373, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK3 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424808(US10508120, Compound I-1413 | US10508120, Compound...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK3 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM424807(US10508120, Compound I-1311 | US10577373, Compound...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK3 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM565754(US11414431, Compound I-322)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK3 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50618788(CHEMBL5427213)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK3 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
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