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Target5-hydroxytryptamine receptor 4(Human)
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Curated by ChEMBL
LigandPNGBDBM50530426(CHEMBL4557961)
Affinity DataEC50:  360nMAssay Description:Inhibition of 5-HT4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
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Curated by ChEMBL
LigandPNGBDBM50499430(CHEMBL3740472)
Affinity DataEC50:  22nMAssay Description:Inhibition of 5-HT4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
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Curated by ChEMBL
LigandPNGBDBM50530426(CHEMBL4557961)
Affinity DataEC50:  360nMAssay Description:Inhibition of 5-HT4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
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Curated by ChEMBL
LigandPNGBDBM50530443(CHEMBL4560185)
Affinity DataEC50:  72nMAssay Description:Inhibition of 5-HT4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50530443(CHEMBL4560185)
Affinity DataEC50:  72nMAssay Description:Inhibition of 5-HT4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50499430(CHEMBL3740472)
Affinity DataEC50:  22nMAssay Description:Inhibition of 5-HT4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
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Curated by ChEMBL
LigandPNGBDBM50562747(CHEMBL4756814)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at human 5HT1A expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by LANCE ultra cAMP detect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50397999(CHEMBL2180796)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human PDE10More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50397999(CHEMBL2180796)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human PDE10More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530441(CHEMBL4448109)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human PDE10More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530441(CHEMBL4448109)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human PDE10More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
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Curated by ChEMBL
LigandPNGBDBM50386935(CHEMBL2048680)
Affinity DataIC50: 2nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
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Curated by ChEMBL
LigandPNGBDBM50386935(CHEMBL2048680)
Affinity DataIC50: 2nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTranslocator protein(Human)
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Curated by ChEMBL
LigandPNGBDBM50530439(CHEMBL4456416)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of TSPO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTranslocator protein(Human)
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Curated by ChEMBL
LigandPNGBDBM50530439(CHEMBL4456416)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of TSPO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530425(CHEMBL4454665)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of FLAG-tagged human PDE4B2 expressed in Escherichia coli cells after 20 mins in presence of [3H]-cAMP by top count analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530425(CHEMBL4454665)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of FLAG-tagged human PDE4B2 expressed in Escherichia coli cells after 20 mins in presence of [3H]-cAMP by top count analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
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Curated by ChEMBL
LigandPNGBDBM50318633(SB-742457 | 3-benzenesulfonyl-8-piperazin-1-ylquin...)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at 5HT6R (unknown origin) transfected in NG108-15 cells co-transfected with CAMYEL assessed as reduction in cAMP levels after 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50318633(SB-742457 | 3-benzenesulfonyl-8-piperazin-1-ylquin...)
Affinity DataIC50: 2.80nMAssay Description:Inverse agonist activity at 5HT6R (unknown origin) expressed in 1321N1 cells co-expressing CAMYEL assessed as reduction in basal cAMP accumulation by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
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Curated by ChEMBL
LigandPNGBDBM50386917(CHEMBL2048662)
Affinity DataIC50: 3nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
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Curated by ChEMBL
LigandPNGBDBM50530427(CHEMBL4562585)
Affinity DataIC50: 3nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
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Curated by ChEMBL
LigandPNGBDBM50386917(CHEMBL2048662)
Affinity DataIC50: 3nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
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Curated by ChEMBL
LigandPNGBDBM50530427(CHEMBL4562585)
Affinity DataIC50: 3nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
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Curated by ChEMBL
LigandPNGBDBM269506((4-(2-chlorophenethyl)piperazin-1- yl)(imidazo[1,2...)
Affinity DataIC50: 4nMAssay Description:Modulator activity at 5-HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
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Curated by ChEMBL
LigandPNGBDBM269506((4-(2-chlorophenethyl)piperazin-1- yl)(imidazo[1,2...)
Affinity DataIC50: 4nMAssay Description:Modulator activity at 5-HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
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Curated by ChEMBL
LigandPNGBDBM50562750(CHEMBL4742804)
Affinity DataIC50: 5.20nMAssay Description:Neutral antagonist activity at 5HT6R (unknown origin) expressed in 1321N1 cells co-expressing CAMYEL assessed as inhibition of WAY181187-induced cAMP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50562747(CHEMBL4756814)
Affinity DataIC50: 5.40nMAssay Description:Neutral antagonist activity at 5HT6R (unknown origin) expressed in 1321N1 cells co-expressing CAMYEL assessed as inhibition of WAY181187-induced cAMP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50530417(CHEMBL4441878)
Affinity DataIC50: 6nMAssay Description:Inhibition of DYRK1A (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530417(CHEMBL4441878)
Affinity DataIC50: 6nMAssay Description:Inhibition of DYRK1A (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
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Curated by ChEMBL
LigandPNGBDBM50562748(CHEMBL4760105)
Affinity DataIC50: 6.40nMAssay Description:Neutral antagonist activity at 5HT6R (unknown origin) expressed in 1321N1 cells co-expressing CAMYEL assessed as inhibition of WAY181187-induced cAMP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50562744(CHEMBL4777550)
Affinity DataIC50: 6.60nMAssay Description:Neutral antagonist activity at 5HT6R (unknown origin) expressed in 1321N1 cells co-expressing CAMYEL assessed as inhibition of WAY181187-induced cAMP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50530430(CHEMBL4460561)
Affinity DataIC50: 7nMAssay Description:Inhibition of DYRK1A (unknown origin) by ADP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530430(CHEMBL4460561)
Affinity DataIC50: 7nMAssay Description:Inhibition of DYRK1A (unknown origin) by ADP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTranslocator protein(Human)
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Curated by ChEMBL
LigandPNGBDBM22041(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of TSPO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTranslocator protein(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM22041(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of TSPO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530429(CHEMBL4575900)
Affinity DataIC50: 8nMAssay Description:Inhibition of DYRK1A (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530429(CHEMBL4575900)
Affinity DataIC50: 8nMAssay Description:Inhibition of DYRK1A (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530417(CHEMBL4441878)
Affinity DataIC50: 9nMAssay Description:Inhibition of DYRK1A (unknown origin) by ADP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530417(CHEMBL4441878)
Affinity DataIC50: 9nMAssay Description:Inhibition of DYRK1A (unknown origin) by ADP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
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Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CYP2D6 (unknown origin) after 2 hrs by firefly luciferase-luminescence based P450-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
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Curated by ChEMBL
LigandPNGBDBM50530423(CHEMBL4451349)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at 5-HT4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50530423(CHEMBL4451349)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at 5-HT4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530430(CHEMBL4460561)
Affinity DataIC50: 11nMAssay Description:Inhibition of DYRK1A (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530430(CHEMBL4460561)
Affinity DataIC50: 11nMAssay Description:Inhibition of DYRK1A (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
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Curated by ChEMBL
LigandPNGBDBM50562754(CHEMBL4799851)
Affinity DataIC50: 11nMAssay Description:Neutral antagonist activity at 5HT6R (unknown origin) expressed in 1321N1 cells co-expressing CAMYEL assessed as inhibition of WAY181187-induced cAMP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetTranslocator protein(Human)
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Curated by ChEMBL
LigandPNGBDBM50060121(2-(6-Nitro-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-N,...)
Affinity DataIC50: 12nMAssay Description:Inhibition of TSPO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530429(CHEMBL4575900)
Affinity DataIC50: 12nMAssay Description:Inhibition of DYRK1A (unknown origin) by ADP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTranslocator protein(Human)
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Curated by ChEMBL
LigandPNGBDBM50060121(2-(6-Nitro-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-N,...)
Affinity DataIC50: 12nMAssay Description:Inhibition of TSPO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530429(CHEMBL4575900)
Affinity DataIC50: 12nMAssay Description:Inhibition of DYRK1A (unknown origin) by ADP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
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Curated by ChEMBL
LigandPNGBDBM50530444(CHEMBL4566900)
Affinity DataIC50: 13nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
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