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TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292202(N-(2-Aminomethyl-5-chloro-benzyl)-2-[3-cyano-6-(2,...)
Affinity DataKi:  0.00100nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147818((2-[6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDOPYRIDIN-2-...)
Affinity DataKi:  0.00140nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147824(2-[6-Chloro-3-(2,2-difluoro-2-pyridin-2-yl-ethylam...)
Affinity DataKi:  0.00150nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292203(N-(5-Chloro-2-tetrazol-1-yl-benzyl)-2-[3-cyano-6-(...)
Affinity DataKi:  0.00200nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156449(2-[(R)-7-Chloro-1-(naphthalene-2-sulfonyl)-3-oxo-1...)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147793(N-(5-Chloro-2-tetrazol-1-yl-benzyl)-2-{3-[2,2-difl...)
Affinity DataKi:  0.0130nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156446(N-{2-[4-(4,5-Dihydro-1H-imidazol-2-yl)-phenyl]-eth...)
Affinity DataKd:  0.0150nMAssay Description:Equilibrium dissociation constant of the [35S]- radiolabeled compound against human Bradykinin receptor B1 expressed in CHO membranes was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337452(2-(4-chloro-2-((2-(6-methyl-2-oxo-3-(2-(pyridin-2-...)
Affinity DataKi:  0.0150nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147788(N-(5-Chloro-2-tetrazol-1-yl-benzyl)-2-(6-methyl-2-...)
Affinity DataKi:  0.0180nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156446(N-{2-[4-(4,5-Dihydro-1H-imidazol-2-yl)-phenyl]-eth...)
Affinity DataKi:  0.0200nMAssay Description:Binding affinity of the [35S]- radiolabeled compound to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156451(2-[(R)-7-Chloro-1-(naphthalene-2-sulfonyl)-3-oxo-1...)
Affinity DataKi:  0.0200nMAssay Description:Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156446(N-{2-[4-(4,5-Dihydro-1H-imidazol-2-yl)-phenyl]-eth...)
Affinity DataKi:  0.0200nMAssay Description:Binding affinity of the [35S]- radiolabeled compound to rhesus monkey Bradykinin receptor B1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156455((R)-N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenethyl)-...)
Affinity DataKi:  0.0300nMAssay Description:Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147809(N-(5-Chloro-2-tetrazol-1-yl-benzyl)-2-[3-(2,2-difl...)
Affinity DataKi:  0.0330nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50295693(CHEMBL557629)
Affinity DataKi:  0.0340nMAssay Description:Displacement of [35S] 4-(1-(3,4-difluorophenyl)-2-(ethyl(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)amino)-2-oxoethyl)-3-oxopip...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156446(N-{2-[4-(4,5-Dihydro-1H-imidazol-2-yl)-phenyl]-eth...)
Affinity DataIC50: 0.0400nMAssay Description:Antagonist activity against human Bradykinin receptor B1 was determined in a fluorescence imaging plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292196(N-(2-Aminomethyl-5-chloro-benzyl)-2-[6-(2,2-difluo...)
Affinity DataKi:  0.0400nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107412(3-(2-{2-Oxo-3-[2-(5,6,7,8-tetrahydro-[1,8]naphthyr...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123490(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-[3-(2,2-...)
Affinity DataKi:  0.0420nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rabbit)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156446(N-{2-[4-(4,5-Dihydro-1H-imidazol-2-yl)-phenyl]-eth...)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity of the [35S]- radiolabeled compound to rabbit Bradykinin receptor B1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292200(2-[3-Chloro-6-(2,2-difluoro-2-pyridin-2-yl-ethylam...)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147812(2-{6-Chloro-3-[2,2-difluoro-2-(1-oxy-pyridin-2-yl)...)
Affinity DataKi:  0.0500nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50295693(CHEMBL557629)
Affinity DataKi:  0.0520nMAssay Description:Displacement of [35S] 4-(1-(3,4-difluorophenyl)-2-(ethyl(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)amino)-2-oxoethyl)-3-oxopip...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM166831(US9688629, 242 | US9802915, Example 242 | US992003...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of recombinant human BTK using fluoresceinated peptide as substrate after 60 mins fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156448(N-{2-[4-(1H-Imidazol-2-yl)-phenyl]-ethyl}-2-[(R)-1...)
Affinity DataKi:  0.0700nMAssay Description:Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156450(2-[(R)-7-Chloro-1-(naphthalene-2-sulfonyl)-3-oxo-1...)
Affinity DataKi:  0.0700nMAssay Description:Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292189(2-[2-(3-Chloro-benzylamino)-2-hydroxy-ethyl]-6-(2,...)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of recombinant human BTK using fluoresceinated peptide as substrate after 60 mins fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147801(N-(5-Chloro-2-[1,2,4]triazol-1-yl-benzyl)-2-{3-[2,...)
Affinity DataKi:  0.0850nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126304(2-{6-Chloro-3-[2,2-difluoro-2-(1-oxy-pyridin-2-yl)...)
Affinity DataKi:  0.0870nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147821(2-[6-Chloro-3-(2,2-difluoro-2-pyridin-2-yl-ethylam...)
Affinity DataKi:  0.0960nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM164638(US9688629, 123 | BDBM166759 | US9802915, Example 1...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human BTK using fluoresceinated peptide as substrate after 60 mins fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetFolate receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50126174(CHEMBL3628346)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to human FRbeta expressed in Chinese hamster D4 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetRenin(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50005417(CHEMBL266334 | N-[(1-Cyclohexylmethyl-2,3-dihydrox...)
Affinity DataIC50: 0.100nMAssay Description:Inhibitory concentration against renin monkey plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123504(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-[3-(2,2-...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107410(3-(2,3-Dihydro-benzofuran-6-yl)-3-(2-{2-oxo-3-[2-(...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337453(2-(4-chloro-2-((2-(6-methyl-2-oxo-3-(2-(pyridin-2-...)
Affinity DataKi:  0.125nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147822(2-[6-Chloro-3-(2,2-difluoro-2-pyridin-2-yl-ethylam...)
Affinity DataKi:  0.140nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetFolate receptor alpha(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50503240(CHEMBL4445651)
Affinity DataIC50: 0.140nMAssay Description:Binding affinity to human FRalpha expressed in Chinese hamster RT16 cells assessed as antiproliferative activity measured as reduction in cell growth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292201(N-(5-Chloro-2-tetrazol-1-yl-benzyl)-2-[6-(2,2-difl...)
Affinity DataKi:  0.140nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM165319(US9688629, 115 | US9802915, Example 115 | US992003...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of recombinant human BTK using fluoresceinated peptide as substrate after 60 mins fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147810(N-(5-Chloro-2-[1,2,4]triazol-1-yl-benzyl)-2-(6-met...)
Affinity DataKi:  0.160nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126303(2-{6-Chloro-3-[2,2-difluoro-2-(1-oxy-pyridin-2-yl)...)
Affinity DataKi:  0.160nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFolate receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50354833(CHEMBL1834488 | AGF94)
Affinity DataIC50: 0.160nMAssay Description:Binding affinity to human FRbeta expressed in Chinese hamster D4 cells assessed as antiproliferative activity measured as reduction in cell growth af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetFolate receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50354833(CHEMBL1834488 | AGF94)
Affinity DataIC50: 0.170nMAssay Description:Binding affinity to human FRbeta expressed in Chinese hamster D4 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetFolate receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50354833(CHEMBL1834488 | AGF94)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of FRbeta (unknown origin) expressed in Chinese hamster D4 cells assessed as cell growth inhibition incubated up to 96 hrs by Celltiter-bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50295690(CHEMBL538424 | (+/-)-2-(3,4-difluorophenyl)-N-ethy...)
Affinity DataKi:  0.180nMAssay Description:Binding affinity to human MCH1R expressed in CHO cells by scintillation counting per mg of proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126309(N-(3-Bromo-benzyl)-2-{6-chloro-3-[2,2-difluoro-2-(...)
Affinity DataKi:  0.190nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFolate receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50503240(CHEMBL4445651)
Affinity DataIC50: 0.190nMAssay Description:Binding affinity to human FRbeta expressed in Chinese hamster D4 cells assessed as antiproliferative activity measured as reduction in cell growth af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50127939((S)-3-(2-{5-Chloro-6-cyclopropyl-2-oxo-3-[(5,6,7,8...)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against human alpha V beta3 receptor using SPAV3 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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