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TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50573875(CHEMBL4869086)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418177(2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM417999(US10457669, Example 675 | US11001575, Example 675)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418019(US10457669, Example 698 | US11001575, Example 698)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418270(US10457669, Example 1054 | (2R)-2-(6-{5-chloro-2-[...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50573874(CHEMBL4873851)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418018(US10457669, Example 697 | US11001575, Example 697)
Affinity DataIC50: 2nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456355(CHEMBL4207147 | US11001575, Example 554)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of ERK1/2 phosphorylation in human A375 cells harboring BRAF V600E mutant after 4 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456356(CHEMBL4209691 | US11001575, Example 674)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50573872(CHEMBL4868536)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418007(US10457669, Example 685 | US10457669, Example 1083...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418315((2R)-2-(3-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50: 3nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50: 3nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418226((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50573873(CHEMBL4870176)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of ERK1/2 in human A375 cells harboring BRAF V600E mutant assessed as suppression of RSK phosphorylation after 4 hrs by MSD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456353(CHEMBL4210682 | US11001575, Example 2)
Affinity DataIC50: 4nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456347(CHEMBL4207117 | US11001575, Example 80)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456351(CHEMBL4217740 | US11001575, Example 103)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456361(CHEMBL4215376 | US11001575, Example 141)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM417431(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin-4- yl}-...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456362(CHEMBL4206693 | US11001575, Example 35)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM575871(US11466016, Example 2 | exo-8-[7-(4- chloro-2- met...)
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant C-terminal truncated human SHP2 (1 to 530 residues) using 6,8-difluoro-4-methylumbelliferyl phosphate as substrate and H2N-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456346(CHEMBL4204392 | US11001575, Example 128)
Affinity DataIC50: 11nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM575873(US11466016, Example 3 | endo-8-[7-(4- chloro-2- me...)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant C-terminal truncated human SHP2 (1 to 530 residues) using 6,8-difluoro-4-methylumbelliferyl phosphate as substrate and H2N-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM418281(US10457669, Example 1072 | (2R)-2-[6-(5-chloro-2-{...)
Affinity DataIC50: 12nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM417432(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin-4- yl}-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50639863(CHEMBL5560927)
Affinity DataKd:  18nMAssay Description:Binding affinity to human Avi/10-his tagged GCase (40 to 536 residues) expressed baculovirus expression system in Sf9 cells in assessed as dissociati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50639082(CHEMBL5542851)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant C-terminal truncated human SHP2 (1 to 530 residues) using 6,8-difluoro-4-methylumbelliferyl phosphate as substrate and H2N-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50639862(CHEMBL5567650)
Affinity DataKd:  19nMAssay Description:Binding affinity to human Avi/10-his tagged GCase (40 to 536 residues) expressed baculovirus expression system in Sf9 cells in assessed as dissociati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8736((2E)-N-methyl-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naph...)
Affinity DataIC50: 20nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2006
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231520(CHEMBL252937 | US8476306, 6.12 | (R)-N-[(S)-1-(4-c...)
Affinity DataIC50: 20nMAssay Description:Inhibition of uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456352(CHEMBL4213926 | US11001575, Example 104)
Affinity DataIC50: 21nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456350(CHEMBL4207587 | US11001575, Example 132)
Affinity DataIC50: 24nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM417517(N-benzyl-2-(6-{5-chloro- 2-[(oxan-4-yl)amino] pyri...)
Affinity DataIC50: 25nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Glaxosmithkline

LigandPNGBDBM8735((E)-N-(1,2-Dimethyl-1H-indol-3-ylmethyl)-N-methyl-...)
Affinity DataIC50: 25nMT: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2006
Entry Details Article
PubMed
LigandPNGBDBM575871(US11466016, Example 2 | exo-8-[7-(4- chloro-2- met...)
Affinity DataIC50: 25nMAssay Description:Inhibition of SHP2 in human HCC827 cells harboring EGFR del 746 to 750 mutant assessed as inhibition of ERK phosphorylation incubated for 30 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456358(CHEMBL4213466 | US11001575, Example 77)
Affinity DataIC50: 26nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456358(CHEMBL4213466 | US11001575, Example 77)
Affinity DataIC50: 26nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Escherichia coli (strain K12))
Glaxosmithkline

LigandPNGBDBM8735((E)-N-(1,2-Dimethyl-1H-indol-3-ylmethyl)-N-methyl-...)
Affinity DataIC50: 30nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2006
Entry Details Article
PubMed
LigandPNGBDBM50639075(CHEMBL5566460)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant C-terminal truncated human SHP2 (1 to 530 residues) using 6,8-difluoro-4-methylumbelliferyl phosphate as substrate and H2N-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50639079(CHEMBL5561613)
Affinity DataIC50: 37nMAssay Description:Inhibition of recombinant C-terminal truncated human SHP2 (1 to 530 residues) using 6,8-difluoro-4-methylumbelliferyl phosphate as substrate and H2N-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetUrokinase-type plasminogen activator(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50147422(3-(4-Chloro-1-guanidino-isoquinolin-7-yl)-benzoic ...)
Affinity DataIC50: 37nMAssay Description:Inhibition of uPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456359(CHEMBL4206737 | US11001575, Example 409)
Affinity DataIC50: 40nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50639077(CHEMBL5556335)
Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant C-terminal truncated human SHP2 (1 to 530 residues) using 6,8-difluoro-4-methylumbelliferyl phosphate as substrate and H2N-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50639868(CHEMBL5562071)
Affinity DataKd:  50nMAssay Description:Binding affinity to human Avi/10-his tagged GCase (40 to 536 residues) expressed baculovirus expression system in Sf9 cells in assessed as dissociati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8732((2E)-N-methyl-N-[(1-methyl-1H-indol-2-yl)methyl]-3...)
Affinity DataIC50: 50nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2006
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8734((2E)-N-methyl-N-[(2-methyl-1H-indol-3-yl)methyl]-3...)
Affinity DataIC50: 50nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2006
Entry Details Article
PubMed
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