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TargetDihydrofolate reductase(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50457437(CHEBI:71223 | Folotyn | PDX | Pralatrexate)
Affinity DataKi:  0.0130nMAssay Description:Inhibition of DHFR (unknown origin) at pH 6.7More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50366620(RESINIFERATOXIN)
Affinity DataKi:  0.0230nMAssay Description:In vitro binding affinity towards vanilloid receptor by [3H]RTX displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM86434(12-Deoxyphorbol 13-phenylacetate | CAS_105100 | NS...)
Affinity DataKi:  0.140nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM86429(CAS_6437389 | NSC_6437389 | Thymeleatoxin | Thymel...)
Affinity DataKi:  0.220nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM86431(CAS_4179 | Mezerein | NSC_4179)
Affinity DataKi:  0.270nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM86429(CAS_6437389 | NSC_6437389 | Thymeleatoxin | Thymel...)
Affinity DataKi:  0.290nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycystin-1(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM86434(12-Deoxyphorbol 13-phenylacetate | CAS_105100 | NS...)
Affinity DataKi:  0.350nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248937(CHEMBL4062168 | US10981896, Compound 15)
Affinity DataKi:  0.390nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycystin-1(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM86431(CAS_4179 | Mezerein | NSC_4179)
Affinity DataKi:  0.430nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycystin-1(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM86432((-)-Octylindolactam V | CAS_159320 | NSC_159320)
Affinity DataKi:  0.450nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248946(CHEMBL1908392 | US10981896, Compound 16)
Affinity DataKi:  0.470nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM86432((-)-Octylindolactam V | CAS_159320 | NSC_159320)
Affinity DataKi:  0.530nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM86431(CAS_4179 | Mezerein | NSC_4179)
Affinity DataKi:  0.550nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM86434(12-Deoxyphorbol 13-phenylacetate | CAS_105100 | NS...)
Affinity DataKi:  0.560nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248938(CHEMBL4089284 | US10981896, Compound 21)
Affinity DataKi:  0.680nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM86432((-)-Octylindolactam V | CAS_159320 | NSC_159320)
Affinity DataKi:  0.770nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50339691(4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperaz...)
Affinity DataKi:  0.800nMAssay Description:Displacement of of [125I]-IABN from human D3 receptor expressed in HEK293 cell membranes after 60 mins by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM12621(2,4-Diamino-5-ketopyrimidine 39 | 5-[(2,3-difluoro...)
Affinity DataKi:  1nMAssay Description:Inhibition of CDK4 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50042844(CHEMBL3353901)
Affinity DataKi:  1.30nMAssay Description:Displacement of of [3H]8-OH-DPAT from human 5HT1A receptor after 60 mins by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50027656(CHEBI:63616 | LY-2315 | LY-231514 | PEMETREXED | U...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of thymidylate synthase (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetProtein kinase C delta type(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM86429(CAS_6437389 | NSC_6437389 | Thymeleatoxin | Thymel...)
Affinity DataKi:  1.31nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human full-length recombinant PARP-1More data for this Ligand-Target Pair
TargetCathepsin B(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  1.60nMAssay Description:Inhibitory activity of the compound against cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNUAK family SNF1-like kinase 1(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248946(CHEMBL1908392 | US10981896, Compound 16)
Affinity DataKi:  1.70nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged NUAK1 expressed in baculovirus infected Sf9 insect cells using CHK peptide as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50042708(CHEMBL3353899)
Affinity DataKi:  1.80nMAssay Description:Displacement of of [125I]-IABN from human D3 receptor expressed in HEK293 cell membranes after 60 mins by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50117910(4''-(2-Butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity at endothelin receptor subtype AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM12621(2,4-Diamino-5-ketopyrimidine 39 | 5-[(2,3-difluoro...)
Affinity DataKi:  2nMAssay Description:Inhibition of CDK1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(3) dopamine receptor(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50042734(CHEMBL3353913)
Affinity DataKi:  2.10nMAssay Description:Displacement of of [125I]-IABN from human D3 receptor expressed in HEK293 cell membranes after 60 mins by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50151435((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to mGLUR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254203(US10112937, Example 88 | US10150765, Example 88 | ...)
Affinity DataKi:  2.20nMAssay Description:Antagonist activity at recombinant rat P2X7 expressed in human 1321N1 cells assessed as inhibition of BzATP-induced calcium flux preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50042729(CHEMBL3353914)
Affinity DataKi:  2.30nMAssay Description:Displacement of of [125I]-IABN from human D3 receptor expressed in HEK293 cell membranes after 60 mins by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248936(CHEMBL4083922 | US10981896, Compound 25)
Affinity DataKi:  2.30nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50339690(4-(2-fluoroethyl)-N-(4-(4-(2-methoxyphenyl)piperaz...)
Affinity DataKi:  2.40nMAssay Description:Displacement of of [125I]-IABN from human D3 receptor expressed in HEK293 cell membranes after 60 mins by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50339690(4-(2-fluoroethyl)-N-(4-(4-(2-methoxyphenyl)piperaz...)
Affinity DataKi:  2.40nMAssay Description:Displacement of of [3H]8-OH-DPAT from human 5HT1A receptor after 60 mins by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM86435(B8-DL-B8 | B8-DL-B8 (low PS))
Affinity DataKi:  2.90nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50042727(CHEMBL3353916)
Affinity DataKi:  2.90nMAssay Description:Displacement of of [125I]-IABN from human D3 receptor expressed in HEK293 cell membranes after 60 mins by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM12621(2,4-Diamino-5-ketopyrimidine 39 | 5-[(2,3-difluoro...)
Affinity DataKi:  3nMAssay Description:Inhibition of CDK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50042721(CHEMBL3353896)
Affinity DataKi:  3.10nMAssay Description:Displacement of of [125I]-IABN from human D3 receptor expressed in HEK293 cell membranes after 60 mins by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248945(CHEMBL4081410 | US10981896, Compound 19)
Affinity DataKi:  3.10nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50042840(CHEMBL3353905)
Affinity DataKi:  3.20nMAssay Description:Displacement of of [125I]-IABN from human D3 receptor expressed in HEK293 cell membranes after 60 mins by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycystin-1(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM86429(CAS_6437389 | NSC_6437389 | Thymeleatoxin | Thymel...)
Affinity DataKi:  3.20nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM86435(B8-DL-B8 | B8-DL-B8 (low PS))
Affinity DataKi:  3.57nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137736((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  3.70nMAssay Description:Inhibitory activity of the compound against cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50042709(CHEMBL3353898)
Affinity DataKi:  3.70nMAssay Description:Displacement of of [125I]-IABN from human D3 receptor expressed in HEK293 cell membranes after 60 mins by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycystin-1(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM86429(CAS_6437389 | NSC_6437389 | Thymeleatoxin | Thymel...)
Affinity DataKi:  3.85nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50042729(CHEMBL3353914)
Affinity DataKi:  3.90nMAssay Description:Displacement of of [3H]8-OH-DPAT from human 5HT1A receptor after 60 mins by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137720((1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(p...)
Affinity DataKi:  4nMAssay Description:Inhibitory activity of the compound against cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50151435((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity to mGLUR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50042723(CHEMBL3353895)
Affinity DataKi:  4.70nMAssay Description:Displacement of of [125I]-IABN from human D3 receptor expressed in HEK293 cell membranes after 60 mins by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
University of Pittsburgh

Curated by PDSP Ki Database
LigandPNGBDBM86433(CAS_454217 | NSC_454217 | Prostratin)
Affinity DataKi:  4.83nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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