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TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250109(CHEMBL4062994)
Affinity DataKd:  6.70E+3nMAssay Description:Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2019
Entry Details Article
PubMed
TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250107(CHEMBL4085628)
Affinity DataKd:  7.80E+4nMAssay Description:Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250108(CHEMBL4096573)
Affinity DataKd:  200nMAssay Description:Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250110(CHEMBL4065757)
Affinity DataKd:  1.71E+5nMAssay Description:Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250111(CHEMBL4084664)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250106(CHEMBL4103560)
Affinity DataKd:  1.25E+4nMAssay Description:Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2019
Entry Details Article
PubMed
TargetTranscriptional enhancer factor TEF-1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50497296(CHEMBL3335452)
Affinity DataKd:  39nMAssay Description:Inhibition of YAP/ GST-TEAD1 interaction in human Bel-7404 cells by GST pull-down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetTranscriptional enhancer factor TEF-1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50497300(CHEMBL3335461)
Affinity DataKd:  15nMAssay Description:Inhibition of YAP/ GST-TEAD1 interaction in human Bel-7404 cells by GST pull-down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetTranscriptional enhancer factor TEF-1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50497293(CHEMBL3335451)
Affinity DataKd:  211nMAssay Description:Inhibition of YAP/ GST-TEAD1 interaction in human Bel-7404 cells by GST pull-down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetTranscriptional enhancer factor TEF-1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50497304(CHEMBL3335453)
Affinity DataKd:  18nMAssay Description:Inhibition of YAP/ GST-TEAD1 interaction in human Bel-7404 cells by GST pull-down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545526(CHEMBL4644629)
Affinity DataEC50:  214nMAssay Description:Agonist activity at GAL-4 fused RORgammat (unknown origin) expressed in Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545527(CHEMBL4645753)
Affinity DataEC50:  623nMAssay Description:Agonist activity at GAL-4 fused RORgammat (unknown origin) expressed in Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545528(CHEMBL4649541)
Affinity DataEC50:  532nMAssay Description:Agonist activity at GAL-4 fused RORgammat (unknown origin) expressed in Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545529(CHEMBL4647240)
Affinity DataEC50:  474nMAssay Description:Agonist activity at GAL-4 fused RORgammat (unknown origin) expressed in Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545530(CHEMBL4648835)
Affinity DataEC50:  123nMAssay Description:Agonist activity at GAL-4 fused RORgammat (unknown origin) expressed in Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545531(CHEMBL4648360)
Affinity DataEC50:  68nMAssay Description:Agonist activity at GAL-4 fused RORgammat (unknown origin) expressed in Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545532(CHEMBL4646223)
Affinity DataEC50:  31nMAssay Description:Agonist activity at GAL-4 fused RORgammat (unknown origin) expressed in Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545533(CHEMBL4648462)
Affinity DataEC50:  27nMAssay Description:Agonist activity at GAL-4 fused RORgammat (unknown origin) expressed in Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545534(CHEMBL4648410)
Affinity DataEC50:  7.70nMAssay Description:Agonist activity at GAL-4 fused RORgammat (unknown origin) expressed in Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545535(CHEMBL4636914)
Affinity DataEC50:  9.40nMAssay Description:Agonist activity at GAL-4 fused RORgammat (unknown origin) expressed in Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545536(CHEMBL4645125)
Affinity DataEC50:  14nMAssay Description:Agonist activity at GAL-4 fused RORgammat (unknown origin) expressed in Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545537(CHEMBL4634701)
Affinity DataEC50:  4.70nMAssay Description:Agonist activity at GAL-4 fused RORgammat (unknown origin) expressed in Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545538(CHEMBL4637719)
Affinity DataEC50:  15nMAssay Description:Agonist activity at GAL-4 fused RORgammat (unknown origin) expressed in Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545539(CHEMBL4642011)
Affinity DataEC50:  5.60nMAssay Description:Agonist activity at GAL-4 fused RORgammat (unknown origin) expressed in Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545540(CHEMBL4644223)
Affinity DataEC50:  7nMAssay Description:Agonist activity at GAL-4 fused RORgammat (unknown origin) expressed in Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545541(CHEMBL4644213)
Affinity DataEC50:  8.5nMAssay Description:Agonist activity at GAL-4 fused RORgammat (unknown origin) expressed in Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-alpha(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545540(CHEMBL4644223)
Affinity DataEC50:  8.40E+3nMAssay Description:Agonist activity at Gal4-fused RORalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-alpha(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545542(CHEMBL4641912)
Affinity DataEC50:  4.20E+3nMAssay Description:Agonist activity at Gal4-fused RORalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-beta(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545540(CHEMBL4644223)
Affinity DataEC50:  8.30E+3nMAssay Description:Agonist activity at Gal4-fused RORbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-beta(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545542(CHEMBL4641912)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at Gal4-fused RORbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Mouse)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545542(CHEMBL4641912)
Affinity DataEC50:  380nMAssay Description:Agonist activity at RORgammat in mouse whole blood assessed as induction of IL-17A expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50545542(CHEMBL4641912)
Affinity DataEC50:  13nMAssay Description:Agonist activity at GAL-4 fused RORgammat (unknown origin) expressed in Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547302(CHEMBL4778165)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547303(CHEMBL4760168)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547304(CHEMBL4776732)
Affinity DataEC50:  1.50E+3nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50:  1.10E+3nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50:  1.10E+3nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547306(CHEMBL4756772)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547307(CHEMBL4782643)
Affinity DataEC50:  3.80E+3nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547308(CHEMBL4759638)
Affinity DataEC50:  1.25E+3nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547309(CHEMBL4753189)
Affinity DataEC50:  690nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547309(CHEMBL4753189)
Affinity DataEC50:  690nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547310(CHEMBL4749059)
Affinity DataEC50:  1.80E+3nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547311(CHEMBL4762020)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547312(CHEMBL4744634)
Affinity DataEC50:  1.30E+3nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547312(CHEMBL4744634)
Affinity DataEC50:  1.30E+3nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547312(CHEMBL4744634)
Affinity DataEC50:  1.54E+3nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547312(CHEMBL4744634)
Affinity DataEC50:  1.54E+3nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547313(CHEMBL4751110)
Affinity DataEC50:  510nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547314(CHEMBL4745281)
Affinity DataEC50:  1.30E+3nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
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