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TargetAcetylcholinesterase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50634023(CHEMBL5439936)
Affinity DataEC50:  2.31E+4nMAssay Description:Inhibition of AChE (unknown origin) by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetBeta-2 adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50465055(CHEMBL4282215)
Affinity DataEC50:  5.10E+3nMAssay Description:Agonist activity at human beta2-AR expressed in CHOK1 cells co-expressing Galpha15 measured after 21 secs to 120 secs by Calcium-4 dye based FLIPR as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Guinea pig)
Shandong University

Curated by ChEMBL
LigandPNGBDBM25392(Isoproterenol,(+) | CHEMBL434 | 4-[1-hydroxy-2-(pr...)
Affinity DataEC50:  7.90nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal smooth muscle assessed as inhibition of histamine-induced tracheal smooth muscle...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50634024(CHEBI:2942 | AZADIRACTIN)
Affinity DataEC50:  6.81E+4nMAssay Description:Inhibition of butyrylcholinesterase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetBeta-2 adrenergic receptor(Guinea pig)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50090488(1-Benzyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol ...)
Affinity DataEC50:  800nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal smooth muscle assessed as inhibition of histamine-induced tracheal smooth muscle...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataEC50:  290nMAssay Description:Agonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-2 adrenergic receptor(Guinea pig)
Shandong University

Curated by ChEMBL
LigandPNGBDBM25392(Isoproterenol,(+) | CHEMBL434 | 4-[1-hydroxy-2-(pr...)
Affinity DataEC50:  7.90nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal smooth muscle assessed as inhibition of histamine-induced tracheal smooth muscle...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataEC50:  75nMAssay Description:Agonist activity at human alpha1 beta adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50634022(CHEMBL2296788)
Affinity DataEC50:  4.13E+4nMAssay Description:Inhibition of butyrylcholinesterase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataKd:  90nMAssay Description:Inhibition of human FLT3 ITD/F691L double mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataKd:  160nMAssay Description:Inhibition of human FLT3 ITD/D835V double mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50634028(CHEMBL5432471)
Affinity DataEC50:  4.68E+4nMAssay Description:Inhibition of human AchE using acetylthiocholine iodide as substrate incubated for 20 mins by Ellman's assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCholinesterase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50634023(CHEMBL5439936)
Affinity DataEC50:  4.69E+4nMAssay Description:Inhibition of butyrylcholinesterase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetBeta-1 adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataEC50:  290nMAssay Description:Agonist activity at human beta1 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-2 adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM25392(Isoproterenol,(+) | CHEMBL434 | 4-[1-hydroxy-2-(pr...)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human beta2 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50465056(CHEMBL4292818)
Affinity DataEC50:  88nMAssay Description:Agonist activity at human beta2-AR expressed in CHOK1 cells co-expressing Galpha15 measured after 21 secs to 120 secs by Calcium-4 dye based FLIPR as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50634027(CHEMBL5399233)
Affinity DataEC50:  5.51E+4nMAssay Description:Inhibition of human AchE using acetylthiocholine iodide as substrate incubated for 20 mins by Ellman's assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetBeta-2 adrenergic receptor(Guinea pig)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50530831(CHEMBL4438390)
Affinity DataEC50:  2.80E+3nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal smooth muscle assessed as inhibition of histamine-induced tracheal smooth muscle...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50634024(CHEBI:2942 | AZADIRACTIN)
Affinity DataEC50:  2.93E+4nMAssay Description:Inhibition of AChE (unknown origin) by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetBeta-2 adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM25392(Isoproterenol,(+) | CHEMBL434 | 4-[1-hydroxy-2-(pr...)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at human beta2-AR expressed in CHOK1 cells co-expressing Galpha15 measured after 21 secs to 120 secs by Calcium-4 dye based FLIPR as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50634026(CHEMBL5440391)
Affinity DataEC50:  4.48E+4nMAssay Description:Inhibition of human AchE using acetylthiocholine iodide as substrate incubated for 20 mins by Ellman's assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50634029(CHEMBL5436417)
Affinity DataEC50:  5.88E+4nMAssay Description:Inhibition of human AchE using acetylthiocholine iodide as substrate incubated for 20 mins by Ellman's assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataEC50:  75nMAssay Description:Agonist activity at human alpha1 beta adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Guinea pig)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50090488(1-Benzyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol ...)
Affinity DataEC50:  800nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal smooth muscle assessed as inhibition of histamine-induced tracheal smooth muscle...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Guinea pig)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50530831(CHEMBL4438390)
Affinity DataEC50:  2.80E+3nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal smooth muscle assessed as inhibition of histamine-induced tracheal smooth muscle...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM25392(Isoproterenol,(+) | CHEMBL434 | 4-[1-hydroxy-2-(pr...)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human beta2 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50634025(CHEMBL5438999)
Affinity DataEC50:  6.57E+4nMAssay Description:Inhibition of human recombinant acetylcholinesterase using acetylthiocholine as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50634022(CHEMBL2296788)
Affinity DataEC50:  1.69E+4nMAssay Description:Inhibition of AChE (unknown origin) by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataKd:  7.30nMAssay Description:Inhibition of human FLT3 D835V mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513250(CHEMBL4475689)
Affinity DataIC50: 0.327nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50010704(Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Ly...)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of binding [3H]U-69539 at Opioid receptor kappa 1 of guinea pig brain membrane (GPB) homogenates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50051599(Dynorphin A analogues | CHEMBL415224)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of binding [3H]U-69539 at Opioid receptor kappa 1 of guinea pig brain membrane (GPB) homogenates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513228(CHEMBL4571743)
Affinity DataIC50: 0.799nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50051595(Dynorphin A analogues | CHEMBL413228)
Affinity DataIC50: 0.890nMAssay Description:Inhibition of binding [3H]U-69539 at Opioid receptor kappa 1 of guinea pig brain membrane (GPB) homogenates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50507645(CHEMBL4473820)
Affinity DataIC50: 0.940nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50051594(Dynorphin A analogues | CHEMBL407303)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of binding [3H]U-69539 at Opioid receptor kappa 1 of guinea pig brain membrane (GPB) homogenates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Mayo Foundation

Curated by ChEMBL
LigandPNGBDBM50004169(3-(4-Chloro-phenyl)-8-methyl-2-vinyl-8-aza-bicyclo...)
Affinity DataIC50: 1.20nMAssay Description:Compound was evaluated for its ability to displace [3H]mazindol binding from rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513240(CHEMBL4459133)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513235(CHEMBL4461271)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Mayo Foundation

Curated by ChEMBL
LigandPNGBDBM50035738(3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50: 1.60nMAssay Description:Compound was evaluated for its ability to displace [3H]mazindol binding from rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513234(CHEMBL4513662)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513236(CHEMBL4522701)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50069559(Biphalin Analogue | CHEMBL2371057)
Affinity DataIC50: 1.70nMAssay Description:Compound was tested for binding affinity towards mu opioid receptor in guinea pig brain homogenates using [3H]CTOP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513245(CHEMBL4457695)
Affinity DataIC50: 2nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513253(CHEMBL4435445)
Affinity DataIC50: 2nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50069563(Biphalin Analogue | CHEMBL2371079)
Affinity DataIC50: 2.20nMAssay Description:Compound was tested for binding affinity towards mu opioid receptor in guinea pig brain homogenates using [3H]CTOP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513241(CHEMBL4469023)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513233(CHEMBL4519177)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
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