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TargetTyrosine-protein kinase JAK1(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100348(US8501944, 374 | US8501944, 370 | US9868729, Examp...)
Affinity DataKd:  6.70nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100349(US8501944, 371 | US9868729, Example 207 | US105330...)
Affinity DataKd:  11nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100350(US8501944, 375 | US8501944, 372 | US9868729, Examp...)
Affinity DataKd:  4.70nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100351(US8501944, 376 | US8501944, 373 | US9868729, Examp...)
Affinity DataKd:  14nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100348(US8501944, 374 | US8501944, 370 | US9868729, Examp...)
Affinity DataKd:  2.90nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100349(US8501944, 371 | US9868729, Example 207 | US105330...)
Affinity DataKd:  3nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100350(US8501944, 375 | US8501944, 372 | US9868729, Examp...)
Affinity DataKd:  2.70nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100351(US8501944, 376 | US8501944, 373 | US9868729, Examp...)
Affinity DataKd:  4.10nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100348(US8501944, 374 | US8501944, 370 | US9868729, Examp...)
Affinity DataKd:  6.70nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100348(US8501944, 374 | US8501944, 370 | US9868729, Examp...)
Affinity DataKd:  5.10nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100348(US8501944, 374 | US8501944, 370 | US9868729, Examp...)
Affinity DataKd:  2.90nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase SYK(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100348(US8501944, 374 | US8501944, 370 | US9868729, Examp...)
Affinity DataKd:  98nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase SYK(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100351(US8501944, 376 | US8501944, 373 | US9868729, Examp...)
Affinity DataKd:  9.40nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100351(US8501944, 376 | US8501944, 373 | US9868729, Examp...)
Affinity DataKd:  4.10nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100351(US8501944, 376 | US8501944, 373 | US9868729, Examp...)
Affinity DataKd:  10nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM100351(US8501944, 376 | US8501944, 373 | US9868729, Examp...)
Affinity DataKd:  14nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medichem Research

Curated by ChEMBL
LigandPNGBDBM50002665(6,6,10,11-Tetramethyl-4-propyl-10,11-dihydro-6H-di...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of HIV-1 reverse transcriptase using a poly(rC):oligo(dG)12-18 template primerMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medichem Research

Curated by ChEMBL
LigandPNGBDBM50002662((10R,11S,12S)-12-Hydroxy-6,6,10,11-tetramethyl-4-p...)
Affinity DataEC50:  320nMAssay Description:Inhibition of HIV-1 reverse transcriptase using a poly(rC):oligo(dG)12-18 template primerMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medichem Research

Curated by ChEMBL
LigandPNGBDBM50057014((10R,12R)-12-Hydroxy-6,6,10,11,11-pentamethyl-4-pr...)
Affinity DataEC50:  3.20E+4nMAssay Description:Inhibition of HIV-1 reverse transcriptase using a poly(rC):oligo(dG)12-18 template primerMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medichem Research

Curated by ChEMBL
LigandPNGBDBM50054452((10R,11R)-6,6,10,11-Tetramethyl-4-propyl-10,11-dih...)
Affinity DataEC50:  4.00E+4nMAssay Description:Inhibition of HIV-1 reverse transcriptase using a poly(rC):oligo(dG)12-18 template primerMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medichem Research

Curated by ChEMBL
LigandPNGBDBM50057028((11S,12S)-12-Hydroxy-6,6,11-trimethyl-4-propyl-11,...)
Affinity DataEC50:  5.00E+4nMAssay Description:Inhibition of HIV-1 reverse transcriptase using a poly(rC):oligo(dG)12-18 template primerMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medichem Research

Curated by ChEMBL
LigandPNGBDBM50057037((11R,12R)-12-Hydroxy-6,6,10,10,11-pentamethyl-4-pr...)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of HIV-1 reverse transcriptase using a poly(rC):oligo(dG)12-18 template primerMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medichem Research

Curated by ChEMBL
LigandPNGBDBM50057029((10R,11S,12S)-10-Ethyl-12-hydroxy-6,6,11-trimethyl...)
Affinity DataEC50:  3.20E+3nMAssay Description:Inhibition of HIV-1 reverse transcriptase using a poly(rC):oligo(dG)12-18 template primerMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medichem Research

Curated by ChEMBL
LigandPNGBDBM50057030((10R,11S,12R)-10-Ethyl-12-hydroxy-6,6,11-trimethyl...)
Affinity DataEC50:  2.00E+3nMAssay Description:Inhibition of HIV-1 reverse transcriptase using a poly(rC):oligo(dG)12-18 template primerMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLutropin-choriogonadotropic hormone receptor(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50206403(N-((S)-1-amino-3-(4-tert-butoxyphenyl)-1-oxopropan...)
Affinity DataEC50:  1.21E+4nMAssay Description:Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLutropin-choriogonadotropic hormone receptor(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50206404((S)-N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-y...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLutropin-choriogonadotropic hormone receptor(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50206400(N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-y...)
Affinity DataEC50:  500nMAssay Description:Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLutropin-choriogonadotropic hormone receptor(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50206405((S)-N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-y...)
Affinity DataEC50:  2.30E+3nMAssay Description:Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLutropin-choriogonadotropic hormone receptor(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50206398(N-(4-hydroxyphenethyl)-5-(1-(4-tert-butylphenyl)-3...)
Affinity DataEC50:  80nMAssay Description:Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLutropin-choriogonadotropic hormone receptor(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50206397((S)-N-(4-amino-4-oxo-1-phenylbutan-2-yl)-5-(1-(4-t...)
Affinity DataEC50:  190nMAssay Description:Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLutropin-choriogonadotropic hormone receptor(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50206402(N-((S)-1-amino-3-(3-hydroxyphenyl)-1-oxopropan-2-y...)
Affinity DataEC50:  150nMAssay Description:Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLutropin-choriogonadotropic hormone receptor(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50206399(N-((S)-2-amino-1-(4-hydroxyphenyl)-2-oxoethyl)-6-(...)
Affinity DataEC50:  170nMAssay Description:Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLutropin-choriogonadotropic hormone receptor(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50206396((S)-2-{3-[2-(4-tert-butyl-phenyl)-5-pyridin-3-yl-2...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLutropin-choriogonadotropic hormone receptor(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50206395((S)-N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-y...)
Affinity DataEC50:  250nMAssay Description:Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLutropin-choriogonadotropic hormone receptor(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50206401(N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-y...)
Affinity DataEC50:  20nMAssay Description:Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 4 group A member 1(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50378798(CYTOSPORONE B)
Affinity DataKd:  1.51E+3nMAssay Description:Binding affinity to NuR77-LBD receptor expressed in human BGC823 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor subfamily 4 group A member 1(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50378798(CYTOSPORONE B)
Affinity DataEC50:  0.115nMAssay Description:Agonist activity at nuclear orphan receptor Nur77 expressed in human BGC823 cells co-transfected with fused GAL4-LBD assessed as transactivation afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor subfamily 4 group A member 1(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50378798(CYTOSPORONE B)
Affinity DataEC50:  0.278nMAssay Description:Agonist activity at nuclear orphan receptor Nur77 expressed in human BGC823 cells co-transfected with fused GAL4-Nur77 assessed as transactivation af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM31892(CHEMBL705 | 9-cis retinoic acid | alitretinoin | P...)
Affinity DataKd:  240nMAssay Description:Binding affinity to RXRalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor subfamily 4 group A member 1(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50378798(CYTOSPORONE B)
Affinity DataKd:  740nMAssay Description:Binding affinity to Nur77 receptor expressed in human BGC823 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSphingosine 1-phosphate receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM23165(CHEMBL366208 | [(2S)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at SIP3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSphingosine 1-phosphate receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM23165(CHEMBL366208 | [(2S)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at SIP1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSphingosine 1-phosphate receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50420008(CHEMBL2032318)
Affinity DataEC50:  0.398nMAssay Description:Agonist activity at SIP1 receptor by tango assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50420009(CHEMBL2032441)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at SIP1 receptor by tango assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50420008(CHEMBL2032318)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human SIP3 receptor assessed as calcium mobilization by GeneBLAzer assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50420010(CHEMBL2032301)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human SIP3 receptor assessed as calcium mobilization by GeneBLAzer assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50420011(CHEMBL2032302)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human SIP3 receptor assessed as calcium mobilization by GeneBLAzer assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50420012(CHEMBL2032303)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human SIP3 receptor assessed as calcium mobilization by GeneBLAzer assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50420013(CHEMBL2032305)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human SIP3 receptor assessed as calcium mobilization by GeneBLAzer assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50420014(CHEMBL2032306)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human SIP3 receptor assessed as calcium mobilization by GeneBLAzer assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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