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TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250674(CHEMBL4076973 | US10961200, Compound 53 | US112479...)
Affinity DataKd:  370nMAssay Description:Binding affinity to human His-tagged LDHA in presence of NADH by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250677(CHEMBL4100845 | US10961200, Compound 52 | US112479...)
Affinity DataKd:  0.330nMAssay Description:Binding affinity to human His-tagged LDHA in presence of NADH by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250656(CHEMBL4081890 | US11247971, Cmpd ID 276)
Affinity DataEC50:  170nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250685(CHEMBL1479261 | US10961200, Compound 62 | US112479...)
Affinity DataEC50: >1.00E+5nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250648(CHEMBL4080497 | US10961200, Compound 20 | US112479...)
Affinity DataEC50:  2.56E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM86137(LDHA Inhibitor, 33)
Affinity DataEC50:  1.60E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50103568(CHEMBL3335794)
Affinity DataKd:  59nMAssay Description:Binding affinity to human His-tagged LDHA in presence of NADH by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250652(CHEMBL4101800 | US10961200, Compound 42 | US112479...)
Affinity DataEC50: >1.00E+5nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250656(CHEMBL4081890 | US11247971, Cmpd ID 276)
Affinity DataKd:  0.110nMAssay Description:Binding affinity to human His-tagged LDHA in presence of NADH by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250674(CHEMBL4076973 | US10961200, Compound 53 | US112479...)
Affinity DataEC50:  3.53E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250677(CHEMBL4100845 | US10961200, Compound 52 | US112479...)
Affinity DataEC50:  250nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250655(CHEMBL4059985 | US10961200, Compound 189 | US11247...)
Affinity DataEC50:  70nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50103568(CHEMBL3335794)
Affinity DataKd:  1.70nMAssay Description:Binding affinity to human His-tagged LDHA in absence of NADH by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM197160(GNE-140 (6))
Affinity DataEC50:  1.26E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50103568(CHEMBL3335794)
Affinity DataEC50:  8.18E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50456222(CHEMBL4206272)
Affinity DataEC50:  5.59E+3nMAssay Description:Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature at 70 degC after 1 hr by CETSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50456223(CHEMBL4206892)
Affinity DataEC50:  2.72E+3nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of 100 nM paclitaxel-mediated cytotoxicity after 4 days by CellTiter-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50456222(CHEMBL4206272)
Affinity DataEC50:  2.00E+3nMAssay Description:Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature after 1 hr by CETSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50456226(CHEMBL4215649)
Affinity DataEC50:  7.79E+3nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of 100 nM paclitaxel-mediated cytotoxicity after 4 days by CellTiter-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50456236(CHEMBL4214533)
Affinity DataEC50:  2.00E+3nMAssay Description:Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature after 1 hr by CETSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50456232(CHEMBL4207617)
Affinity DataEC50:  2.00E+3nMAssay Description:Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature after 1 hr by CETSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50456223(CHEMBL4206892)
Affinity DataEC50:  3.40E+3nMAssay Description:Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature at 70 degC after 1 hr by CETSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50456236(CHEMBL4214533)
Affinity DataEC50:  2.04E+3nMAssay Description:Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature at 70 degC after 1 hr by CETSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50456248(CHEMBL4212457)
Affinity DataEC50:  2.22E+3nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of 100 nM paclitaxel-mediated cytotoxicity after 4 days by CellTiter-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50456223(CHEMBL4206892)
Affinity DataEC50:  2.00E+3nMAssay Description:Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature after 1 hr by CETSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50456222(CHEMBL4206272)
Affinity DataEC50:  1.12E+4nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of 100 nM paclitaxel-mediated cytotoxicity after 4 days by CellTiter-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50456248(CHEMBL4212457)
Affinity DataEC50: >5.00E+3nMAssay Description:Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature after 1 hr by CETSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50456248(CHEMBL4212457)
Affinity DataEC50: >5.00E+4nMAssay Description:Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature at 70 degC after 1 hr by CETSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50456232(CHEMBL4207617)
Affinity DataEC50:  3.15E+3nMAssay Description:Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature at 70 degC after 1 hr by CETSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50456247(CHEMBL4213848)
Affinity DataEC50:  1.93E+3nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of 100 nM paclitaxel-mediated cytotoxicity after 4 days by CellTiter-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50076741(CHEMBL3416562)
Affinity DataEC50:  3.04E+3nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of 100 nM paclitaxel-mediated cytotoxicity after 4 days by CellTiter-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466243(CHEMBL4286609)
Affinity DataKd:  140nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRD4 long isoform bromodomain 1/2 (N44 to E460 residues) expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466244(CHEMBL4276844)
Affinity DataKd:  550nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRD4 long isoform bromodomain 1/2 (N44 to E460 residues) expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466245(CHEMBL4291988)
Affinity DataKd:  85nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRD4 long isoform bromodomain 1/2 (N44 to E460 residues) expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466246(CHEMBL4286125)
Affinity DataKd:  60nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRD4 long isoform bromodomain 1/2 (N44 to E460 residues) expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466247(CHEMBL4293058)
Affinity DataKd:  270nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRD4 long isoform bromodomain 1/2 (N44 to E460 residues) expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466248(CHEMBL4276978)
Affinity DataKd:  110nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRD4 long isoform bromodomain 1/2 (N44 to E460 residues) expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466249(CHEMBL4290047)
Affinity DataKd:  73nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRD4 long isoform bromodomain 1/2 (N44 to E460 residues) expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466250(CHEMBL4295090)
Affinity DataKd:  570nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRD4 long isoform bromodomain 1/2 (N44 to E460 residues) expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466251(CHEMBL4289664)
Affinity DataKd:  520nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRD4 long isoform bromodomain 1/2 (N44 to E460 residues) expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466252(CHEMBL4278335)
Affinity DataKd:  480nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRD4 long isoform bromodomain 1/2 (N44 to E460 residues) expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466253(CHEMBL4293430)
Affinity DataKd:  56nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRD4 long isoform bromodomain 1/2 (N44 to E460 residues) expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466254(CHEMBL4288569)
Affinity DataKd:  27nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRD2 isoform 1 bromodomain 1/2 (K71 to D455 residues) expressed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466254(CHEMBL4288569)
Affinity DataKd:  20nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRD3 bromodomain 1/2 (P24 to P416 residues) expressed in Escher...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466254(CHEMBL4288569)
Affinity DataKd:  21nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRD3 bromodomain 2 (G306 to P416 residues) expressed in Escheri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466254(CHEMBL4288569)
Affinity DataKd:  18nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRD4 long isoform bromodomain 1 (N44 to E168 residues) expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain testis-specific protein(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466254(CHEMBL4288569)
Affinity DataKd:  67nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRDT isoform b bromodomain 1/2 (N21 to E382 residues) expressed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBromodomain testis-specific protein(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466254(CHEMBL4288569)
Affinity DataKd:  160nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRDT isoform b bromodomain 2 (K250 to E382 residues) expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466255(CHEMBL4280407)
Affinity DataKd:  980nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRD4 long isoform bromodomain 1/2 (N44 to E460 residues) expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50466256(CHEMBL4284925)
Affinity DataKd:  140nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length BRD4 long isoform bromodomain 1/2 (N44 to E460 residues) expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
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