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TargetRNA-directed RNA polymerase(Hepacivirus C)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50482398(CHEMBL1210273)
Affinity DataKd:  4.48E+3nMAssay Description:Inhibition of HCV NS5B polymerase L419M mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50482399(CHEMBL1210272)
Affinity DataKd:  3.99E+3nMAssay Description:Inhibition of HCV NS5B polymerase M414T mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50482398(CHEMBL1210273)
Affinity DataKd:  597nMAssay Description:Inhibition of HCV NS5B polymerase M414T mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM35554(thiophene scaffold, 21)
Affinity DataKd:  427nMAssay Description:Inhibition of HCV NS5B polymerase L419M mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM35554(thiophene scaffold, 21)
Affinity DataKd:  33nMAssay Description:Inhibition of HCV NS5B polymerase M414T mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50482399(CHEMBL1210272)
Affinity DataKd:  2.31E+4nMAssay Description:Inhibition of HCV NS5B polymerase L419M mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50156548(5-(2-((R)-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxopyrro...)
Affinity DataEC50:  12nMAssay Description:Functional activity at human EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50156550(3-(3-((R)-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxopyrro...)
Affinity DataEC50: >1.00E+4nMAssay Description:Functional activity at human EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50156553(4-(2-((R)-2-((S,E)-5-cyclobutyl-3-hydroxypent-1-en...)
Affinity DataEC50:  0.200nMAssay Description:Functional activity at human EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50156549(4-(2-((S)-2-((S)-3-hydroxyoctyl)-5-oxopyrrolidin-1...)
Affinity DataEC50:  130nMAssay Description:Functional activity at human EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50156554(4-(2-((R)-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxopyrro...)
Affinity DataEC50:  17nMAssay Description:Functional activity at human EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50156556(2-(2-((R)-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxopyrro...)
Affinity DataEC50:  1.07E+4nMAssay Description:Functional activity at human EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50156555(2-(4-((R)-2-((S,E)-3-hydroxy-4-(3-(trifluoromethyl...)
Affinity DataEC50:  180nMAssay Description:Functional activity at human EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50156547(4-(2-((R)-2-((S)-3-hydroxyoct-1-enyl)-5-oxopyrroli...)
Affinity DataEC50:  11nMAssay Description:Functional activity at human EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50156551(4-{2-[(2S)-2-[(3R)-3-[3-(4-chloro-2-methylphenyl)p...)
Affinity DataEC50:  0.0400nMAssay Description:Functional activity at human EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50156552(4-(2-((R)-2-((S,E)-3-hydroxy-4-(3-(methoxymethyl)p...)
Affinity DataEC50:  5.90nMAssay Description:Functional activity at human EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50142481(8-aza-11-deoxyprostaglandin E1 | 7-[(R)-2-((E)-(S)...)
Affinity DataEC50:  56nMAssay Description:Functional activity at human EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50156546(4-(2-((S)-2-((S)-5-cyclobutyl-3-hydroxypentyl)-5-o...)
Affinity DataEC50:  150nMAssay Description:Functional activity at human EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50156557(2-(4-((R)-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxopyrro...)
Affinity DataEC50:  2.10E+3nMAssay Description:Functional activity at human EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426601(CHEMBL2325895)
Affinity DataKd:  16nMAssay Description:Binding affinity to TYK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426601(CHEMBL2325895)
Affinity DataKd:  12nMAssay Description:Binding affinity to JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426601(CHEMBL2325895)
Affinity DataKd:  0.180nMAssay Description:Binding affinity to JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426601(CHEMBL2325895)
Affinity DataKd:  0.120nMAssay Description:Binding affinity to JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433252(CHEMBL2376144)
Affinity DataKd:  73nMAssay Description:Binding affinity to JAK1 (unknown origin) by ligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433252(CHEMBL2376144)
Affinity DataKd:  11nMAssay Description:Binding affinity to JAK2 (unknown origin) by ligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433252(CHEMBL2376144)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to JAK3 (unknown origin) by ligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426601(CHEMBL2325895)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of JAK3 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433240(CHEMBL2376157)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of JAK3 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433243(CHEMBL2376154)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of JAK3 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426601(CHEMBL2325895)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of JAK3 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433254(CHEMBL2376040)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of JAK3 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426599(CHEMBL2325898)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of JAK3 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426607(CHEMBL2325897)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of JAK1 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426599(CHEMBL2325898)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of JAK2 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426599(CHEMBL2325898)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of JAK1 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433249(CHEMBL2376147)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of JAK3 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlasma kallikrein(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM306556(US10144746, Compound 199 | (1R,8S)-N-[(4-carbamimi...)
Affinity DataIC50: 0.741nMAssay Description:The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPlasma kallikrein(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM306613(US10144746, Compound 256 | (1R,8S)-N-[(4-carbamimi...)
Affinity DataIC50: 0.759nMAssay Description:The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPlasma kallikrein(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM306637(US10144746, Compound 280 | (1R,8S)-N-[(4-carbamimi...)
Affinity DataIC50: 0.759nMAssay Description:The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426601(CHEMBL2325895)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of JAK2 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433242(CHEMBL2376155)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of JAK3 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433253(CHEMBL2376143)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of JAK3 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433254(CHEMBL2376040)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of JAK2 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426601(CHEMBL2325895)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of JAK2 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433243(CHEMBL2376154)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of JAK1 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of JAK1 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlasma kallikrein(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM306528(US10144746, Compound 170 | (+-)-N-[(4-carbamimidoy...)
Affinity DataIC50: 1nMAssay Description:The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPlasma kallikrein(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM306535(US10144746, Compound 178 | (1R,8S)-N-[(6-amino-2,4...)
Affinity DataIC50: 1nMAssay Description:The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPlasma kallikrein(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM306536(US10144746, Compound 179 | (1R,8S)-N-[(6-amino-2,4...)
Affinity DataIC50: 1nMAssay Description:The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPlasma kallikrein(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM306538(US10144746, Compound 181 | (1R,8S)-N-[(6-amino-2,4...)
Affinity DataIC50: 1nMAssay Description:The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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