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Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50462180(CHEMBL149482)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human 5-HT1AR expressed in HEK293 cells assessed as increase in calcium flux by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50462141(CHEMBL4248491)
Affinity DataEC50:  11nMAssay Description:Partial agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in cAMP accumulation by chemiluminescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50462158(CHEMBL4239823)
Affinity DataEC50:  28nMAssay Description:Partial agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in cAMP accumulation by chemiluminescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  4.5nMAssay Description:Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  5.70nMAssay Description:Agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in calcium flux by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50530426(CHEMBL4557961)
Affinity DataEC50:  360nMAssay Description:Inhibition of 5-HT4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50499430(CHEMBL3740472)
Affinity DataEC50:  22nMAssay Description:Inhibition of 5-HT4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50530426(CHEMBL4557961)
Affinity DataEC50:  360nMAssay Description:Inhibition of 5-HT4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50530443(CHEMBL4560185)
Affinity DataEC50:  72nMAssay Description:Inhibition of 5-HT4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50530443(CHEMBL4560185)
Affinity DataEC50:  72nMAssay Description:Inhibition of 5-HT4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50499430(CHEMBL3740472)
Affinity DataEC50:  22nMAssay Description:Inhibition of 5-HT4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50562747(CHEMBL4756814)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at human 5HT1A expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by LANCE ultra cAMP detect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50425434(CHEMBL2312640)
Affinity DataEC50:  1.50E+4nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50425435(CHEMBL2312639)
Affinity DataEC50:  1.55E+4nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50425436(CHEMBL2312637)
Affinity DataEC50:  865nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM21393(cid_1220 | CHEMBL56 | 7-(dipropylamino)-5,6,7,8-te...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50425437(CHEMBL2312935)
Affinity DataEC50:  1.65E+3nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50425438(CHEMBL2312934)
Affinity DataEC50:  7.40E+3nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50198639(CHEMBL3894175)
Affinity DataEC50:  105nMAssay Description:Intrinsic activity at human alpha1B adrenergic receptor expressed in CHOK1 cells co-expressing aequorin assessed as inhibition of agonist induced cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50198640(CHEMBL3947830)
Affinity DataEC50:  11nMAssay Description:Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50198641(CHEMBL3937911)
Affinity DataEC50:  148nMAssay Description:Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50198642(CHEMBL3948333)
Affinity DataEC50:  461nMAssay Description:Intrinsic activity at human alpha1B adrenergic receptor expressed in CHOK1 cells co-expressing aequorin assessed as inhibition of agonist induced cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50198642(CHEMBL3948333)
Affinity DataEC50:  192nMAssay Description:Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50198643(CHEMBL3939560)
Affinity DataEC50:  100nMAssay Description:Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50198644(CHEMBL3956998)
Affinity DataEC50:  121nMAssay Description:Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50198645(CHEMBL3895815)
Affinity DataEC50:  14nMAssay Description:Intrinsic activity at human alpha1B adrenergic receptor expressed in CHOK1 cells co-expressing aequorin assessed as inhibition of agonist induced cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50198641(CHEMBL3937911)
Affinity DataEC50:  13nMAssay Description:Intrinsic activity at human alpha1B adrenergic receptor expressed in CHOK1 cells co-expressing aequorin assessed as inhibition of agonist induced cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50198640(CHEMBL3947830)
Affinity DataEC50:  42nMAssay Description:Intrinsic activity at human alpha1B adrenergic receptor expressed in CHOK1 cells co-expressing aequorin assessed as inhibition of agonist induced cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50033111(6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)p...)
Affinity DataEC50:  1.70nMAssay Description:Intrinsic activity at human alpha1B adrenergic receptor expressed in CHOK1 cells co-expressing aequorin assessed as inhibition of agonist induced cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50067212(CHEBI:8093 | Cyclomydril | Duo-Medihaler | Phenyle...)
Affinity DataEC50:  0.860nMAssay Description:Intrinsic activity at human alpha1B adrenergic receptor expressed in CHOK1 cells co-expressing aequorin assessed as calcium mobilization measured for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50198644(CHEMBL3956998)
Affinity DataEC50:  16nMAssay Description:Intrinsic activity at human alpha1B adrenergic receptor expressed in CHOK1 cells co-expressing aequorin assessed as inhibition of agonist induced cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50067212(CHEBI:8093 | Cyclomydril | Duo-Medihaler | Phenyle...)
Affinity DataEC50:  56nMAssay Description:Intrinsic activity at alpha1A adrenergic receptor (unknown origin) after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50060964(5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]...)
Affinity DataEC50:  0.0700nMAssay Description:Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50198646(CHEMBL3986337)
Affinity DataEC50:  140nMAssay Description:Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50198643(CHEMBL3939560)
Affinity DataEC50:  608nMAssay Description:Intrinsic activity at human alpha1B adrenergic receptor expressed in CHOK1 cells co-expressing aequorin assessed as inhibition of agonist induced cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50198639(CHEMBL3894175)
Affinity DataEC50:  34nMAssay Description:Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50198647(CHEMBL3968662)
Affinity DataEC50:  599nMAssay Description:Intrinsic activity at human alpha1B adrenergic receptor expressed in CHOK1 cells co-expressing aequorin assessed as inhibition of agonist induced cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50033111(6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)p...)
Affinity DataEC50:  52nMAssay Description:Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50198647(CHEMBL3968662)
Affinity DataEC50:  161nMAssay Description:Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50198645(CHEMBL3895815)
Affinity DataEC50:  84nMAssay Description:Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50198646(CHEMBL3986337)
Affinity DataEC50:  515nMAssay Description:Intrinsic activity at human alpha1B adrenergic receptor expressed in CHOK1 cells co-expressing aequorin assessed as inhibition of agonist induced cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50060964(5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]...)
Affinity DataEC50:  0.130nMAssay Description:Intrinsic activity at human alpha1B adrenergic receptor expressed in CHOK1 cells co-expressing aequorin assessed as inhibition of agonist induced cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50397999(CHEMBL2180796)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human PDE10More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50397999(CHEMBL2180796)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human PDE10More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530441(CHEMBL4448109)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human PDE10More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530441(CHEMBL4448109)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human PDE10More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50060686(4-(4-Methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinoxal...)
Affinity DataIC50: 0.370nMAssay Description:Displacement of [3H]-BRL 43694 from 5-HT3 receptor in rat cortex membrane incubated for 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50605031(CHEMBL5174789)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human recombinant MAO-B using p-tyramine as substrate preincubated for 30 mins followed by substrate addition and measured after 1 hr b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50605030(CHEMBL5209131)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant MAO-B using p-tyramine as substrate preincubated for 30 mins followed by substrate addition and measured after 1 hr b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50417287(Aloxi | Aurothioglucose | PALONOSETRON | PALONOSET...)
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at human 5-HT3 receptor expressed in CHO-K1 cells assessed as inhibition of 5-HT induced inward currents preincubated for 30 sec ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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