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TargetE3 ubiquitin-protein ligase Mdm2(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31285(BMCL163310 Compound 1 | CHEMBL361103 | benzodiazep...)
Affinity DataKd:  80nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31286(benzodiazepinedione, 2)
Affinity DataKd:  4.80E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIntegrin beta-3/subunit alpha 2b(Rat)
Capital Medical University

Curated by ChEMBL
LigandPNGBDBM50453875(CHEMBL1811964)
Affinity DataEC50:  1.66E+3nMAssay Description:Binding affinity to GP2b/3a in rat blood assessed as conformational change by measuring soluble GP2b/3a levels after 12 hrs by UV-spectrophotometric ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin beta-3(Rat)
Capital Medical University

Curated by ChEMBL
LigandPNGBDBM50453876(CHEMBL4212580)
Affinity DataEC50:  1.16E+3nMAssay Description:Binding affinity to GP2b/3a in rat blood assessed as conformational change by measuring soluble GP2b/3a levels after 12 hrs by UV-spectrophotometric ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50463215(CHEMBL4246780)
Affinity DataEC50:  1.40E+4nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in Wistar rat 3rd-order mesenteric artery assessed as reduction in norepinephrine-induced vess...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50463216(CHEMBL4251191)
Affinity DataEC50:  7.30E+3nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in Wistar rat 3rd-order mesenteric artery assessed as reduction in norepinephrine-induced vess...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50463217(CHEMBL4241124)
Affinity DataEC50:  1.40E+4nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in Wistar rat 3rd-order mesenteric artery assessed as reduction in norepinephrine-induced vess...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50463218(CHEMBL4240985)
Affinity DataEC50:  2.20E+4nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in Wistar rat 3rd-order mesenteric artery assessed as reduction in norepinephrine-induced vess...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50463219(CHEMBL4246908)
Affinity DataEC50:  1.20E+4nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in Wistar rat 3rd-order mesenteric artery assessed as reduction in norepinephrine-induced vess...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50463220(CHEMBL4243120)
Affinity DataEC50:  4.10E+3nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in Wistar rat 3rd-order mesenteric artery assessed as reduction in norepinephrine-induced vess...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Rat)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467472(CHEMBL4281766)
Affinity DataEC50:  63nMAssay Description:Inhibition of PDE5 in Wistar rat mesentric arteries assessed as inhibition of phenylephrine-induced contraction by measuring increase in acetylcholin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Rat)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467474(CHEMBL4289471)
Affinity DataEC50:  55nMAssay Description:Inhibition of PDE5 in Wistar rat mesentric arteries assessed as inhibition of phenylephrine-induced contraction by measuring increase in acetylcholin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Rat)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467473(CHEMBL4292389)
Affinity DataEC50:  191nMAssay Description:Inhibition of PDE5 in Wistar rat mesentric arteries assessed as inhibition of phenylephrine-induced contraction by measuring increase in acetylcholin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Rat)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467477(CHEMBL4277243)
Affinity DataEC50:  58nMAssay Description:Inhibition of PDE5 in Wistar rat mesentric arteries assessed as inhibition of phenylephrine-induced contraction by measuring increase in acetylcholin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Rat)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467484(CHEMBL4281590)
Affinity DataEC50:  725nMAssay Description:Inhibition of PDE5 in Wistar rat mesentric arteries assessed as inhibition of phenylephrine-induced contraction by measuring increase in acetylcholin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Rat)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467490(CHEMBL4278136)
Affinity DataEC50:  71nMAssay Description:Inhibition of PDE5 in Wistar rat mesentric arteries assessed as inhibition of phenylephrine-induced contraction by measuring increase in acetylcholin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Rat)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467488(CHEMBL4286052)
Affinity DataEC50:  30nMAssay Description:Inhibition of PDE5 in Wistar rat mesentric arteries assessed as inhibition of phenylephrine-induced contraction by measuring increase in acetylcholin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Rat)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467491(CHEMBL4289291)
Affinity DataEC50:  225nMAssay Description:Inhibition of PDE5 in Wistar rat mesentric arteries assessed as inhibition of phenylephrine-induced contraction by measuring increase in acetylcholin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Rat)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467479(CHEMBL4281081)
Affinity DataEC50:  103nMAssay Description:Inhibition of PDE5 in Wistar rat mesentric arteries assessed as inhibition of phenylephrine-induced contraction by measuring increase in acetylcholin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Rat)
Shandong University

Curated by ChEMBL
LigandPNGBDBM14777(CHEMBL779 | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-m...)
Affinity DataEC50:  78nMAssay Description:Inhibition of PDE5 in Wistar rat mesentric arteries assessed as inhibition of phenylephrine-induced contraction by measuring increase in acetylcholin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50469334(CHEMBL4278302)
Affinity DataEC50: >1.00E+4nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208313(US9266835, 541)
Affinity DataEC50:  399nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208405(US9266835, 84)
Affinity DataEC50:  269nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208379(US9266835, 40)
Affinity DataEC50:  204nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50469335(CHEMBL4293431)
Affinity DataEC50:  66nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208392(US9266835, 65)
Affinity DataEC50:  64nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208347(US9266835, 108)
Affinity DataEC50:  310nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208402(US9266835, 80)
Affinity DataEC50: >1.00E+4nMAssay Description:Inverse agonist activity at human CB2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208294(US9266835, 106)
Affinity DataEC50:  1.55E+3nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208294(US9266835, 106)
Affinity DataEC50:  6.50E+3nMAssay Description:Inverse agonist activity at human CB2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208281(US9266835, 57)
Affinity DataEC50:  11nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50469336(CHEMBL4292183)
Affinity DataEC50:  322nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208380(US9266835, 42)
Affinity DataEC50:  2.33E+3nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208384(US9266835, 47)
Affinity DataEC50:  75nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50469337(CHEMBL4284299)
Affinity DataEC50:  5nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50469338(CHEMBL4282821)
Affinity DataEC50:  113nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50469339(CHEMBL4286610)
Affinity DataEC50: >1.00E+4nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208374(US9266835, 33)
Affinity DataEC50:  1.21E+3nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208326(US9266835, 28)
Affinity DataEC50:  396nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50469340(CHEMBL4277974)
Affinity DataEC50:  165nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208271(US9266835, 44)
Affinity DataEC50: >1.00E+4nMAssay Description:Inverse agonist activity at human CB2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208390(US9266835, 62)
Affinity DataEC50:  29nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208277(US9266835, 72)
Affinity DataEC50:  11nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208354(US9266835, 137)
Affinity DataEC50:  290nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208289(US9266835, 49)
Affinity DataEC50:  24nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208289(US9266835, 49)
Affinity DataEC50: >1.00E+4nMAssay Description:Inverse agonist activity at human CB2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208305(US9266835, 140)
Affinity DataEC50:  13nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208306(US9266835, 100)
Affinity DataEC50:  6nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208306(US9266835, 100)
Affinity DataEC50:  200nMAssay Description:Inverse agonist activity at human CB2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM208308(US9266835, 141)
Affinity DataEC50: >1.00E+4nMAssay Description:Inverse agonist activity at human CB2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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