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Report error Found 2675 with Last Name = 'zhi' and Initial = 'l'
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataIC50: 0.0500nMAssay Description:Activity at androgen receptor in human Saos2 cells assessed as IL6 repressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214935(5-fluoro-2-((Z)-(9-hydroxy-10-methoxy-2,2,4-trimet...)
Affinity DataIC50: 0.100nMAssay Description:Antagonist activity at GR assessed as inhibition of dexamethasone-induced GRE activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18623((18Z)-12-methoxy-18-({3-[(1E)-1-(methoxyimino)ethy...)
Affinity DataKi:  1.10nM ΔG°:  -47.5kJ/mole IC50: 0.200nM EC50:  0.100nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2007
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067678(17-Acetoxy-6alpha-methylprogesterone | 17alpha-Hyd...)
Affinity DataEC50:  0.150nMAssay Description:Agonistic activity against human progesterone receptor expressed in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067678(17-Acetoxy-6alpha-methylprogesterone | 17alpha-Hyd...)
Affinity DataEC50:  0.150nMAssay Description:Agonist activity was determined against hPR (human progesterone receptor) compared to that of progesterone (100%)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067678(17-Acetoxy-6alpha-methylprogesterone | 17alpha-Hyd...)
Affinity DataEC50:  0.150nMAssay Description:Effective concentration (EC50) against human progesterone receptor expressed in CV-1 cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129152((6S,8S,10R,14S,15S)-17-Acetyl-6,10-dimethyl-13-(R)...)
Affinity DataEC50:  0.150nMAssay Description:Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067678(17-Acetoxy-6alpha-methylprogesterone | 17alpha-Hyd...)
Affinity DataEC50:  0.150nMAssay Description:Agonistic activity to the human progesterone receptor (hPR)assayed in CV-1 cells in cotransfection assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067678(17-Acetoxy-6alpha-methylprogesterone | 17alpha-Hyd...)
Affinity DataEC50:  0.150nMAssay Description:Compound was tested for agonistic activity by cotransfection assay against human Progesterone receptor in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18627(Mifeprex | (10S,11S,14S,15S,17R)-17-[4-(dimethylam...)
Affinity DataIC50: 0.180nMAssay Description:Antagonistic activity against human progesterone receptor B (hPR-B) in co-transfected CV-1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50373235(CHEMBL256769)
Affinity DataIC50: 0.200nMAssay Description:Activity at androgen receptor in human Saos2 cells assessed as IL6 repressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18524(6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromet...)
Affinity DataKi:  4.60nM ΔG°:  -49.5kJ/mole EC50:  0.200nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214928((Z)-(2-((9-hydroxy-10-methoxy-2,2,4-trimethyl-1,2-...)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at GR by GRE activation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50373240(CHEMBL427898)
Affinity DataIC50: 0.200nMAssay Description:Activity at androgen receptor in human Saos2 cells assessed as IL6 repressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataKi:  0.200nM ΔG°:  -57.6kJ/mole EC50:  5.10nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18207(dexamethasone (tetramethyl-rhodamine conjugated ) ...)
Affinity DataKi:  2.10nM ΔG°:  -46.0kJ/mole IC50: 1.40nM EC50:  0.200nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338317((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18616((18Z)-18-{[3-(hydroxymethyl)thiophen-2-yl]methylid...)
Affinity DataKi:  0.700nM ΔG°:  -48.6kJ/mole IC50: 0.200nM EC50:  0.200nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18617((18Z)-12-methoxy-18-{[3-(methoxymethyl)thiophen-2-...)
Affinity DataKi:  0.200nM ΔG°:  -51.5kJ/mole IC50: 0.200nM EC50:  0.200nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18588(6-[(2,2-difluoroethyl)(2,2,2-trifluoroethyl)amino]...)
Affinity DataKi:  1.70nM ΔG°:  -52.1kJ/mole EC50:  0.200nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18620(2-{[(18Z)-13-hydroxy-12-methoxy-3,5,5-trimethyl-17...)
Affinity DataIC50: 0.800nM EC50:  0.200nMpH: 7.5Assay Description:GR-Mediated Agonist Activity Assay- GR-mediated activation by compounds is measured against maximal activation of dexamethasone in the same experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to human androgen receptor expressed in monkey COS7 cells by whole cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334054((+/-)-(3R,4S)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-t...)
Affinity DataIC50: 0.200nMAssay Description:Transrepression activity at glucocorticoid receptor in TNFalpha/IL1beta-stimulated human HepG2 cells assessed as inhibition of NFkappaB-dependent E-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataKi:  0.200nM ΔG°:  -57.6kJ/mole EC50:  5.10nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18629((18Z)-12-methoxy-3,5,5-trimethyl-18-({3-[(1S)-2,2,...)
Affinity DataIC50: 0.200nM EC50:  0.200nMpH: 7.5Assay Description:GR-Mediated Antagonist Activity Assay- GR-mediated antagonist activity is measured in the presence of a concentration of dexamethasone empirically de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214932((Z)-5-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methy...)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at GR by GRE activation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataKi:  0.200nM EC50:  5.10nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214944(10-methoxy-2,2,4-trimethyl-5-[1-m-tolyl-meth-(Z)-y...)
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at GR assessed as inhibition of dexamethasone-induced GRE activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18627(Mifeprex | (10S,11S,14S,15S,17R)-17-[4-(dimethylam...)
Affinity DataIC50: 0.300nMAssay Description:Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18628((18Z)-12-methoxy-3,5,5-trimethyl-18-{[3-(2,2,2-tri...)
Affinity DataKi:  1.40nM ΔG°:  -47.0kJ/mole IC50: 0.400nM EC50:  0.300nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2007
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18627(Mifeprex | (10S,11S,14S,15S,17R)-17-[4-(dimethylam...)
Affinity DataEC50:  0.300nMAssay Description:Antagonistic activity at human progesterone receptor in CV-1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataKi:  0.300nM ΔG°:  -56.5kJ/mole EC50:  5.70nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18189((1R,2S,10S,11S,14S,15S,17S)-1-fluoro-14,17-dihydro...)
Affinity DataKi:  5.70nM ΔG°:  -48.9kJ/mole EC50:  0.300nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18615((18Z)-12-methoxy-3,5,5-trimethyl-18-{[3-(piperidin...)
Affinity DataIC50: 1nM EC50:  0.300nMpH: 7.5Assay Description:GR-Mediated Agonist Activity Assay- GR-mediated activation by compounds is measured against maximal activation of dexamethasone in the same experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2007
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072024((11R,13S,14S,17S)-11-(4-Dimethylamino-phenyl)-17-h...)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity against human progesterone receptor B (hPR-B) in co-transfected CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18621(1-(2-{[(18Z)-13-hydroxy-12-methoxy-3,5,5-trimethyl...)
Affinity DataIC50: 0.300nM EC50:  0.600nMpH: 7.5Assay Description:GR-Mediated Agonist Activity Assay- GR-mediated activation by compounds is measured against maximal activation of dexamethasone in the same experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50403728(CHEMBL2112312)
Affinity DataIC50: 0.300nMAssay Description:In vitro binding affinity at human androgen receptor transfected into COS cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50373232(CHEMBL257151)
Affinity DataIC50: 0.300nMAssay Description:Activity at androgen receptor in human Saos2 cells assessed as IL6 repressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062432(5-(3-Chloro-phenyl)-9-fluoro-2,2,4-trimethyl-2,5-d...)
Affinity DataKi:  0.320nMAssay Description:Compound was evaluated for its binding affinity against baculovirus expressed Progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067678(17-Acetoxy-6alpha-methylprogesterone | 17alpha-Hyd...)
Affinity DataEC50:  0.330nMAssay Description:Agonistic activity by cotransfection assay against human Progesterone receptor in T47D cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067678(17-Acetoxy-6alpha-methylprogesterone | 17alpha-Hyd...)
Affinity DataEC50:  0.330nMAssay Description:Agonistic activity against human progesterone receptor in T47D breast cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067678(17-Acetoxy-6alpha-methylprogesterone | 17alpha-Hyd...)
Affinity DataKi:  0.340nMAssay Description:The binding affinity on Human progesterone receptor (hPR-A) using progesterone as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129152((6S,8S,10R,14S,15S)-17-Acetyl-6,10-dimethyl-13-(R)...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity for human progesterone receptor; Not activeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067678(17-Acetoxy-6alpha-methylprogesterone | 17alpha-Hyd...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067678(17-Acetoxy-6alpha-methylprogesterone | 17alpha-Hyd...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity against human progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067678(17-Acetoxy-6alpha-methylprogesterone | 17alpha-Hyd...)
Affinity DataKi:  0.340nMAssay Description:Compound was evaluated for its binding affinity against baculovirus expressed Progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067678(17-Acetoxy-6alpha-methylprogesterone | 17alpha-Hyd...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity was determined against hPR-A (human progesterone receptor) using progesterone radioligand in competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18578(6-[bis(2,2-difluoroethyl)amino]-4-(trifluoromethyl...)
Affinity DataKi:  0.5nM ΔG°:  -55.2kJ/mole EC50:  0.400nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18579(6-[(2-chloro-2,2-difluoroethyl)(2,2-difluoroethyl)...)
Affinity DataKi:  2.30nM ΔG°:  -51.3kJ/mole EC50:  0.400nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340671(5,7-difluoro-6-(1H-indol-7-yl)-2,2-dimethyl-2,3-di...)
Affinity DataKi:  0.400nMAssay Description:Displacement of radiolabeled Dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
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