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Sodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL

BDBM50325766(3-(2'-chlorobiphenyl-4-yl)-1H-pyrazole-1-carboxami...)

Ki: 0.111nMAssay Description:Inhibition of human Nav 1.7 channel by electrophysiologyMore data for this Ligand-Target Pair

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Bromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50459819(CHEMBL4228445)

Ki: 0.180nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD3 bromodomain 1 (24 to 144 residues) (unknown origin) expressed in ...More data for this Ligand-Target Pair

PDB KEGG
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Bromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50459819(CHEMBL4228445)

Ki: 0.210nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD3 bromodomain 2 (306 to 417residues) (unknown origin) expressed in ...More data for this Ligand-Target Pair

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Bromodomain-containing protein 2(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50459819(CHEMBL4228445)

Ki: 0.270nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD2 bromodomain 2 (349 to 460 residues) (unknown origin) expressed in...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50453810(CHEMBL4208405)

Ki: <0.5nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 DE...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50453769(CHEMBL4214978)

PDB Reactome pathway KEGG
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Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50459819(CHEMBL4228445)

Ki: 0.5nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) expressed in ...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50366704(CHEMBL4166630)

Ki: 0.5nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 Escherichia coli DE3 cell...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM179480(US9675697, Cpd. No. 68)

Ki: <0.5nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 2 (333 to 460 residues) expressed in Rosetta2 D...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50453807(CHEMBL4211497)

Bromodomain-containing protein 3 [326-398](Human)
The Regents of The University of Michigan

US Patent

BDBM179480(US9675697, Cpd. No. 68)

Ki: 0.650nM ΔG°: -52.4kJ/moleT: 25°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50453810(CHEMBL4208405)

Ki: 0.700nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 2 (333 to 460 residues) expressed in Rosetta2 D...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50366716(CHEMBL4174669)

Ki: 0.700nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 Escherichia coli DE3 cell...More data for this Ligand-Target Pair

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Details Article PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM179480(US9675697, Cpd. No. 68)

Ki: 0.800nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 DE...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM179480(US9675697, Cpd. No. 68)

Ki: 0.800nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 Escherichia coli DE3 cell...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50366724(CHEMBL4172277)

Bromodomain-containing protein 3 [326-398](Human)
The Regents of The University of Michigan

US Patent

BDBM179633(US9675697, Cpd. No. 316)

Ki: 0.820nM ΔG°: -51.9kJ/moleT: 25°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50453769(CHEMBL4214978)

Ki: 0.900nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 2 (333 to 460 residues) expressed in Rosetta2 D...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Bromodomain-containing protein 2(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50459819(CHEMBL4228445)

Ki: 0.900nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD2 bromodomain 1 (72 to 205 residues) (unknown origin) expressed in ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-A2/Cyclin-dependent kinase 1(Human)
Glaxosmithkline

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

Ki: 1nM ΔG°: -50.9kJ/molepH: 7.4 T: 22°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair

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Apoptosis regulator Bcl-2(Human)
Wuhan University School of Pharmaceutical Sciences

Curated by ChEMBL

BDBM50162774(ABT-199 | US11420968, Example ABT-199 | Venetoclax)

Ki: <1nMAssay Description:Inhibition of FAM-Bid binding to human BCL2 expressed in Escherichia coli BL21 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50366670(CHEMBL4173488)

Ki: <1nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 Escherichia coli DE3 cell...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50366721(CHEMBL4171109)

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50366699(CHEMBL4169068)

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50366710(CHEMBL4161145)

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50366717(CHEMBL4176849)

PDB Reactome pathway KEGG
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Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50366707(CHEMBL4164393)

Ki: 1nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 Escherichia coli DE3 cell...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50366678(CHEMBL4167996)

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50366748(CHEMBL4172447)

Bromodomain-containing protein 3 [326-398](Human)
The Regents of The University of Michigan

US Patent

BDBM179574(US9675697, Cpd. No. 212)

Ki: 1nM ΔG°: -51.4kJ/moleT: 25°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50459819(CHEMBL4228445)

Ki: 1nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD4 bromodomain 2 (333 to 460 residues) (unknown origin) expressed in...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50453800(CHEMBL4209113)

Ki: 1.10nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 DE...More data for this Ligand-Target Pair

Bromodomain-containing protein 3 [326-398](Human)
The Regents of The University of Michigan

US Patent

BDBM179638(US9675697, Cpd. No. 319)

Ki: 1.10nM ΔG°: -51.1kJ/moleT: 25°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50366692(CHEMBL4162784)

Ki: 1.20nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 Escherichia coli DE3 cell...More data for this Ligand-Target Pair

Bromodomain-containing protein 3 [326-398](Human)
The Regents of The University of Michigan

US Patent

BDBM179493(US9675697, Cpd. No. 211)

Ki: 1.20nM ΔG°: -50.9kJ/moleT: 25°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair

Bromodomain-containing protein 3 [326-398](Human)
The Regents of The University of Michigan

US Patent

BDBM179492(US9675697, Cpd. No. 207)

Ki: 1.30nM ΔG°: -50.7kJ/moleT: 25°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair

Bromodomain-containing protein 3 [326-398](Human)
The Regents of The University of Michigan

US Patent

BDBM179491(US9675697, Cpd. No. 197)

PDB Reactome pathway KEGG
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B.MOAD antibodypedia GoogleScholar

Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM179481(US9675697, Cpd. No. 73)

Ki: 1.40nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 2 (333 to 460 residues) expressed in Rosetta2 D...More data for this Ligand-Target Pair

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3D Structure (crystal)

Bromodomain-containing protein 3 [326-398](Human)
The Regents of The University of Michigan

US Patent

BDBM179490(US9675697, Cpd. No. 196)

Ki: 1.40nM ΔG°: -50.5kJ/moleT: 25°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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B.MOAD antibodypedia GoogleScholar

Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50453808(CHEMBL4203276)

Ki: 1.60nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 2 (333 to 460 residues) expressed in Rosetta2 D...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Bromodomain-containing protein 2(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50520653(CHEMBL4555209)

Ki: 1.70nMAssay Description:Binding affinity to human BRD2 BD1 (72 to 205 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair

Bromodomain-containing protein 2 [364-436](Human)
The Regents of The University of Michigan

US Patent

BDBM179480(US9675697, Cpd. No. 68)

Ki: 1.70nM ΔG°: -50.1kJ/moleT: 25°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50366714(CHEMBL4168913)

Ki: 1.70nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 Escherichia coli DE3 cell...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50366705(CHEMBL4159422)

Ki: 2nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 Escherichia coli DE3 cell...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50520669(CHEMBL4544682)

Ki: 2.10nMAssay Description:Binding affinity to human BRD4 BD1 (44 to 168 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair

Bromodomain-containing protein 2 [91-163](Human)
The Regents of The University of Michigan

US Patent

BDBM179638(US9675697, Cpd. No. 319)

Ki: 2.20nM ΔG°: -49.4kJ/moleT: 25°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair

Bromodomain-containing protein 3 [326-398](Human)
The Regents of The University of Michigan

US Patent

BDBM179627(US9675697, Cpd. No. 213)

Bromodomain-containing protein 3 [326-398](Human)
The Regents of The University of Michigan

US Patent

BDBM179639(US9675697, Cpd. No. 322)

Ki: 2.30nM ΔG°: -49.3kJ/moleT: 25°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Bromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL

BDBM50520653(CHEMBL4555209)

Ki: 2.30nMAssay Description:Binding affinity to human BRD4 BD1 (44 to 168 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair