Compile Data Set for Download or QSAR
maximum 50k data
Found 26 of ic50 for UniProtKB: P00533
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM238271(US9409887, I-2)
Affinity DataIC50: <1nMpH: 7.5Assay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM287608(N-(2-(2-(dimethylamino)ethoxyl)-4-methoxy-5-(7-(1-...)
Affinity DataIC50:  1nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM238270(US9409887, I-1)
Affinity DataIC50: <1nMpH: 7.5Assay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM287595(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50:  1nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM287615(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50:  1nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM238274(US9409887, I-5)
Affinity DataIC50: <1nMpH: 7.5Assay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM287617(US10085983, Compound J-12)
Affinity DataIC50:  1.90nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM287609( N-(4-methoxy-5-(7-(1-methyl-1H-pyrazol-4-yl)pyrro...)
Affinity DataIC50:  2nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM287607(N-(2-(4-(dimethylamino)piperidin-1-yl)-4-methoxy-5...)
Affinity DataIC50:  2nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM287612(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50:  2nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  2nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM287613(N-(5(7-cyclopropylpyrrolo[1,2-f][1,2,4]triazin-2-y...)
Affinity DataIC50:  2nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM287611(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50:  2.40nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM287616(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50:  2.40nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM287610(N-(5(7-cyclohexenyl-pyrrolo[1,2-f][1,2,4]triazin-2...)
Affinity DataIC50:  3nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM238272(US9409887, I-3)
Affinity DataIC50:  5nMpH: 7.5Assay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM238273(US9409887, I-4)
Affinity DataIC50:  5nMpH: 7.5Assay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM287618(N-(2-(4-(dimethylamino)piperidin-1-yl)-4-methoxy-5...)
Affinity DataIC50:  5nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50:  5nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM287619(N-(2-(4-(dimethylamino)piperidin-1-yl)-4-methoxy-5...)
Affinity DataIC50:  9nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM287621(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50:  12nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM287614(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50:  16nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM50123163(CHEMBL3622672 | US9388160, 12)
Affinity DataIC50:  22nMpH: 7.4 T: 2°CAssay Description:The assay was performed using Kinase-Glo Plus luminescence kinase assay kit (Promega). The compounds were diluted in 10% DMSO and 5 μl of the dilu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM50123163(CHEMBL3622672 | US9388160, 12)
Affinity DataIC50: <100nMpH: 7.4 T: 2°CAssay Description:The assay was performed using Kinase-Glo Plus luminescence kinase assay kit (Promega). The compounds were diluted in 10% DMSO and 5 μl of the dilu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM287620(N-(5(7-cyclopropylpyrrolo[1,2-f][1,2,4]triazin-2-y...)
Affinity DataIC50:  262nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM287622(The Preparation of N-(2-(4-(dimethylamino)piperidi...)
Affinity DataIC50:  294nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent