Compile Data Set for Download or QSAR
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TargetBromodomain-containing protein 3 [306-416](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205431((6S+2S)-PEG1 (7))
Affinity DataKi:  0.00270nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 3 [24-144,306-416](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205453(MTI (35))
Affinity DataKi:  0.0120nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 3 [24-144](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205453(MTI (35))
Affinity DataKi:  0.0590nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 3 [306-416](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205453(MTI (35))
Affinity DataKi:  0.0700nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 3 [24-144,306-416](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205431((6S+2S)-PEG1 (7))
Affinity DataKi:  0.110nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 3 [24-144](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205431((6S+2S)-PEG1 (7))
Affinity DataKi:  0.130nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50459819(CHEMBL4228445)
Affinity DataKi:  0.180nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD3 bromodomain 1 (24 to 144 residues) (unknown origin) expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50459819(CHEMBL4228445)
Affinity DataKi:  0.210nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD3 bromodomain 2 (306 to 417residues) (unknown origin) expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 3 [326-398](Human)
University of Michigan

US Patent
LigandPNGBDBM179480(US9675697, Cpd. No. 68)
Affinity DataKi:  0.650nM ΔG°:  -12.5kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3 [326-398](Human)
University of Michigan

US Patent
LigandPNGBDBM179633(US9675697, Cpd. No. 316)
Affinity DataKi:  0.820nM ΔG°:  -12.4kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3 [326-398](Human)
University of Michigan

US Patent
LigandPNGBDBM179574(US9675697, Cpd. No. 212)
Affinity DataKi:  1nM ΔG°:  -12.3kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3 [326-398](Human)
University of Michigan

US Patent
LigandPNGBDBM179638(US9675697, Cpd. No. 319)
Affinity DataKi:  1.10nM ΔG°:  -12.2kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3 [326-398](Human)
University of Michigan

US Patent
LigandPNGBDBM179493(US9675697, Cpd. No. 211)
Affinity DataKi:  1.20nM ΔG°:  -12.2kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3 [326-398](Human)
University of Michigan

US Patent
LigandPNGBDBM179492(US9675697, Cpd. No. 207)
Affinity DataKi:  1.30nM ΔG°:  -12.1kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3 [326-398](Human)
University of Michigan

US Patent
LigandPNGBDBM179491(US9675697, Cpd. No. 197)
Affinity DataKi:  1.30nM ΔG°:  -12.1kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3 [326-398](Human)
University of Michigan

US Patent
LigandPNGBDBM179490(US9675697, Cpd. No. 196)
Affinity DataKi:  1.40nM ΔG°:  -12.1kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50617610(CHEMBL5435922)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to recombinant human BRD3 BD2 (306 to 417 residues) assessed as inhibition constant by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50617607(CHEMBL5394107)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to recombinant human BRD3 BD2 (306 to 417 residues) assessed as inhibition constant by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3 [326-398](Human)
University of Michigan

US Patent
LigandPNGBDBM179627(US9675697, Cpd. No. 213)
Affinity DataKi:  2.20nM ΔG°:  -11.8kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3 [326-398](Human)
University of Michigan

US Patent
LigandPNGBDBM179639(US9675697, Cpd. No. 322)
Affinity DataKi:  2.30nM ΔG°:  -11.8kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50617608(CHEMBL5423636)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to recombinant human BRD3 BD2 (306 to 417 residues) assessed as inhibition constant by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50617605(CHEMBL5418787)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to recombinant human BRD3 BD2 (306 to 417 residues) assessed as inhibition constant by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to human BRD3 BD1 (24 to 144 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50617604(CHEMBL5437043)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to recombinant human BRD3 BD2 (306 to 417 residues) assessed as inhibition constant by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3 [326-398](Human)
University of Michigan

US Patent
LigandPNGBDBM179481(US9675697, Cpd. No. 73)
Affinity DataKi:  2.60nM ΔG°:  -11.7kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50617609(CHEMBL5432216)
Affinity DataKi:  2.80nMAssay Description:Binding affinity to recombinant human BRD3 BD2 (306 to 417 residues) assessed as inhibition constant by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50092310(US9675697, Cpd. No. 23 | CHEMBL3581661)
Affinity DataKi:  3.20nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD3 BD2 (306 to 417 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 3 [326-398](Human)
University of Michigan

US Patent
LigandPNGBDBM50092310(US9675697, Cpd. No. 23 | CHEMBL3581661)
Affinity DataKi:  3.20nM ΔG°:  -11.6kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3 [326-398](Human)
University of Michigan

US Patent
LigandPNGBDBM179637(US9675697, Cpd. No. 317)
Affinity DataKi:  3.5nM ΔG°:  -11.5kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataKi:  4nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD3 BD2 (306 to 417 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataKi:  4nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD3 bromodomain 2 (306 to 417residues) (unknown origin) expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 3 [326-398](Human)
University of Michigan

US Patent
LigandPNGBDBM50092341(US9675697, Cpd. No. 22 | CHEMBL3581660)
Affinity DataKi:  4.20nM ΔG°:  -11.4kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50092341(US9675697, Cpd. No. 22 | CHEMBL3581660)
Affinity DataKi:  4.20nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD3 BD2 (306 to 417 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 3 [326-398](Human)
University of Michigan

US Patent
LigandPNGBDBM179485(US9675697, Cpd. No. 183)
Affinity DataKi:  4.70nM ΔG°:  -11.4kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50617602(CHEMBL5430924)
Affinity DataKi:  4.70nMAssay Description:Binding affinity to recombinant human BRD3 BD2 (306 to 417 residues) assessed as inhibition constant by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50617599(CHEMBL5417801)
Affinity DataKi:  4.80nMAssay Description:Binding affinity to recombinant human BRD3 BD2 (306 to 417 residues) assessed as inhibition constant by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 82 | US10633379, Example 35)
Affinity DataKi:  4.90nMAssay Description:Inhibition of BRD3 BD2 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50617596(CHEMBL5436817)
Affinity DataKi:  5nMAssay Description:Binding affinity to recombinant human BRD3 BD2 (306 to 417 residues) assessed as inhibition constant by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50617601(CHEMBL5422958)
Affinity DataKi:  5nMAssay Description:Binding affinity to recombinant human BRD3 BD2 (306 to 417 residues) assessed as inhibition constant by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3 [51-123](Human)
University of Michigan

US Patent
LigandPNGBDBM179480(US9675697, Cpd. No. 68)
Affinity DataKi:  5.10nM ΔG°:  -11.3kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50515771(CHEMBL4528047)
Affinity DataKi:  5.30nMAssay Description:Binding affinity to human recombinant BRD3 BD2 (306 to 417 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50544938(CHEMBL4094346 | US11059801, Compound dBET1)
Affinity DataKi:  5.30nMAssay Description:Binding affinity to recombinant human BRD3 BD2 (306 to 417 residues) assessed as inhibition constant by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50515771(CHEMBL4528047)
Affinity DataKi:  5.30nMAssay Description:Binding affinity to recombinant human BRD3 BD2 (306 to 417 residues) assessed as inhibition constant by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50617606(CHEMBL5393972)
Affinity DataKi:  5.40nMAssay Description:Binding affinity to recombinant human BRD3 BD2 (306 to 417 residues) assessed as inhibition constant by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50617600(CHEMBL5438712)
Affinity DataKi:  5.70nMAssay Description:Binding affinity to recombinant human BRD3 BD2 (306 to 417 residues) assessed as inhibition constant by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50617603(CHEMBL5414218)
Affinity DataKi:  5.90nMAssay Description:Binding affinity to recombinant human BRD3 BD2 (306 to 417 residues) assessed as inhibition constant by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3 [51-123](Human)
University of Michigan

US Patent
LigandPNGBDBM179485(US9675697, Cpd. No. 183)
Affinity DataKi:  6.10nM ΔG°:  -11.2kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50617598(CHEMBL5429493)
Affinity DataKi:  6.30nMAssay Description:Binding affinity to recombinant human BRD3 BD2 (306 to 417 residues) assessed as inhibition constant by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3 [51-123](Human)
University of Michigan

US Patent
LigandPNGBDBM179638(US9675697, Cpd. No. 319)
Affinity DataKi:  6.30nM ΔG°:  -11.2kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataKi:  6.5nMAssay Description:Binding affinity to human BRD3 BD2 (306 to 417 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
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