Compile Data Set for Download or QSAR
Report error Found 128 of ec50 data for polymerid = 2142
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 34143BDBM34143(CHEMBL175835 | E-6837)
Affinity DataKi:  0.700nM ΔG°:  -13.0kcal/mole EC50:  0.290nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 34154BDBM34154(CHEMBL515307 | indenylsulfonamide, 15)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as stimulation of cAMP level after 30 mins by HTRF assay Inhibition of ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50266578BDBM50266578(N-{3-[2-(Dimethylamino)ethyl]-2-methyl-1H-inden-5-...)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as stimulation of cAMP level after 30 mins by HTRF assay Inhibition of ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 34144BDBM34144((R)-5a | WAY-466)
Affinity DataKi:  1nM ΔG°:  -12.8kcal/mole EC50:  0.400nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 34145BDBM34145(pyrrolidinylindole, (R)-5b)
Affinity DataKi:  0.400nM ΔG°:  -13.3kcal/mole EC50:  4.5nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50159209BDBM50159209(3,5-Dimethyl-isoxazole-4-sulfonic acid [3-((R)-1-m...)
Affinity DataEC50:  0.800nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 34153BDBM34153(CHEMBL476006 | indenylsulfonamide, 14)
Affinity DataEC50:  0.900nMAssay Description:Agonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as stimulation of cAMP level after 30 mins by HTRF assay Inhibition of ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 34147BDBM34147(CHEMBL425196 | pyrrolidinylindole, 6)
Affinity DataKi:  1nM ΔG°:  -12.8kcal/mole EC50:  53.3nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50159196BDBM50159196(3-Chloro-N-(3-(S)-1-pyrrolidin-2-ylmethyl-1H-indol...)
Affinity DataEC50:  1nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 21351BDBM21351(4-{[3-(2-aminoethyl)-1H-indole-1-]sulfonyl}aniline...)
Affinity DataKi:  1nM ΔG°:  -12.1kcal/mole EC50:  91nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50171235BDBM50171235(5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Affinity DataEC50:  1nMAssay Description:Partial agonist activity at 5-HT6 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50159194BDBM50159194(4-Fluoro-N-[3-((R)-1-methyl-pyrrolidin-2-ylmethyl)...)
Affinity DataEC50:  1.10nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50159180BDBM50159180(2-Chloro-N-[3-((S)-1-methyl-pyrrolidin-2-ylmethyl)...)
Affinity DataEC50:  1.10nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50159175BDBM50159175(2-Chloro-N-(3-(R)-1-pyrrolidin-2-ylmethyl-1H-indol...)
Affinity DataEC50:  1.30nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50159178BDBM50159178(4-Methyl-N-[3-((R)-1-methyl-pyrrolidin-2-ylmethyl)...)
Affinity DataEC50:  1.30nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50159201BDBM50159201(2-Fluoro-N-[3-((R)-1-methyl-pyrrolidin-2-ylmethyl)...)
Affinity DataEC50:  1.30nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50159181BDBM50159181(N-(3-(R)-1-Pyrrolidin-2-ylmethyl-1H-indol-5-yl)-be...)
Affinity DataEC50:  1.40nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50159187BDBM50159187(3-Chloro-N-[3-((S)-1-methyl-pyrrolidin-2-ylmethyl)...)
Affinity DataEC50:  1.60nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 34148BDBM34148(CHEMBL371292 | piperidinylindole, 7)
Affinity DataKi:  2nM ΔG°:  -12.3kcal/mole EC50:  24nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 21358BDBM21358(2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...)
Affinity DataKi:  2nM ΔG°:  -11.7kcal/mole EC50:  6.5nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 21358BDBM21358(2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...)
Affinity DataKi:  2nM ΔG°:  -12.3kcal/mole EC50:  6.5nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50159188BDBM50159188(4-Methoxy-N-[3-((S)-1-methyl-pyrrolidin-2-ylmethyl...)
Affinity DataEC50:  2.20nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50159192BDBM50159192(4-Iodo-N-[3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1...)
Affinity DataEC50:  2.70nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50159190BDBM50159190(N-[3-((S)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataEC50:  2.90nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 34149BDBM34149(CHEMBL94422 | N-benzenesulfonylgramine antagonist,...)
Affinity DataKi:  3nM ΔG°:  -12.1kcal/mole EC50:  880nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50159202BDBM50159202(N-[3-((S)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataEC50:  3.20nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50266555BDBM50266555(N-(3-(2-(dimethylamino)ethyl)-2-methyl-1H-inden-5-...)
Affinity DataEC50:  3.20nMAssay Description:Agonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as stimulation of cAMP level after 30 mins by HTRF assay Inhibition of ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50159206BDBM50159206(N-(3-(R)-1-Pyrrolidin-2-ylmethyl-1H-indol-5-yl)-4-...)
Affinity DataEC50:  4.20nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 34145BDBM34145(pyrrolidinylindole, (R)-5b)
Affinity DataEC50:  4.5nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50159210BDBM50159210(4-Chloro-N-(3-(R)-1-pyrrolidin-2-ylmethyl-1H-indol...)
Affinity DataEC50:  4.5nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50159177BDBM50159177(2,4-Difluoro-N-(3-(R)-1-pyrrolidin-2-ylmethyl-1H-i...)
Affinity DataEC50:  5.20nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50159184BDBM50159184(N-(3-(R)-1-Pyrrolidin-2-ylmethyl-1H-indol-5-yl)-3-...)
Affinity DataEC50:  5.80nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 21345BDBM21345(2-{1-[(3-chlorobenzene)sulfonyl]-1H-indol-3-yl}eth...)
Affinity DataKi:  6nM ΔG°:  -11.1kcal/mole EC50:  109nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 21354BDBM21354(2-{1-[(5-chlorothiophene-2-)sulfonyl]-1H-indol-3-y...)
Affinity DataKi:  6nM ΔG°:  -11.1kcal/mole EC50:  181nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 21358BDBM21358(2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...)
Affinity DataEC50:  6.5nMAssay Description:Agonist activity at human 5HT6 receptor expressed in HeLa cells assessed as induction of cAMP production after 10 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 21353BDBM21353(2-{1-[(3,4-dimethoxybenzene)sulfonyl]-1H-indol-3-y...)
Affinity DataKi:  7nM ΔG°:  -11.0kcal/mole EC50:  17.5nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 21355BDBM21355(2-{1-[(5-bromothiophene-2-)sulfonyl]-1H-indol-3-yl...)
Affinity DataKi:  7nM ΔG°:  -11.0kcal/mole EC50:  54nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50300828BDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataEC50:  7.30nMAssay Description:Agonist activity at human 5-HT6 receptor expressed in HeLa cells after 10 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50300828BDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataEC50:  7.30nMAssay Description:Agonist activity at human HT6 receptor expressed in human HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50300828BDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataEC50:  7.30nMAssay Description:Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 21349BDBM21349(2-{1-[(4-methylbenzene)sulfonyl]-1H-indol-3-yl}eth...)
Affinity DataKi:  8nM ΔG°:  -10.9kcal/mole EC50:  191nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 21357BDBM21357(5-{[3-(2-aminoethyl)-1H-indole-1-]sulfonyl}-4-meth...)
Affinity DataKi:  10nM ΔG°:  -10.8kcal/mole EC50:  9.60nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 34146BDBM34146(pyrrolidinylindole, (S)-5b)
Affinity DataKi:  10nM ΔG°:  -11.3kcal/mole EC50:  21.6nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 21341BDBM21341(2-[1-(benzenesulfonyl)-1H-indol-3-yl]ethan-1-amine...)
Affinity DataKi:  10nM ΔG°:  -10.8kcal/mole EC50:  73nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 21347BDBM21347(2-{1-[(4-chlorobenzene)sulfonyl]-1H-indol-3-yl}eth...)
Affinity DataKi:  10nM ΔG°:  -10.8kcal/mole EC50:  174nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 21343BDBM21343(2-{1-[(2-bromobenzene)sulfonyl]-1H-indol-3-yl}etha...)
Affinity DataKi:  11nM ΔG°:  -10.7kcal/mole EC50:  148nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 34150BDBM34150(CHEMBL328816 | 4-(3-methyl-1H-indole-1-sulfonyl)an...)
Affinity DataKi:  12nM ΔG°:  -11.2kcal/mole EC50:  320nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50266639BDBM50266639(3-(2-(dimethylamino)ethyl)-2-methyl-N-(naphthalen-...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as stimulation of cAMP level after 30 mins by HTRF assay Inhibition of ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50300825BDBM50300825(N,N-Dimethyl-N-(2-{3-[(3-chlorophenyl)sulfonyl]-1H...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandChemical structure of BindingDB Monomer ID 50300824BDBM50300824(2-{3-[(3-Chlorophenyl)sulfonyl]-1H-pyrrolo[2,3-b]p...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
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