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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328390BDBM328390(US9663498, Example 30 | 3-(difluoromethyl)-6-fluor...)
Affinity DataIC50: 0.0660nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328384BDBM328384(US9663498, Example 24 | 3-(difluoromethyl)-5-fluor...)
Affinity DataIC50: 0.0740nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328391BDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 0.0850nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328397BDBM328397(US9663498, Example 40 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 0.0900nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328394BDBM328394(US9663498, Example 34 | 3-(difluoromethyl)-6-bromo...)
Affinity DataIC50: 0.0900nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328396BDBM328396(US9663498, Example 39 | 6-chloro-1-((3-(4-cyclopro...)
Affinity DataIC50: 0.0920nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328392BDBM328392(US9663498, Example 32 | 3-(difluoromethyl)-6-chlor...)
Affinity DataIC50: 0.100nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328395BDBM328395(US9663498, Example 37 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 0.130nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328380BDBM328380(US9663498, Example 20 | 6-chloro-1-((4-methoxy-3-(...)
Affinity DataIC50: 0.140nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328400BDBM328400(US9663498, Example 45 | 3-(difluoromethyl)-1-((4-m...)
Affinity DataIC50: 0.140nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328381BDBM328381(US9663498, Example 21 | 6-bromo-1-((4-methoxy-3-(4...)
Affinity DataIC50: 0.170nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50156203BDBM50156203(CHEMBL3781299)
Affinity DataIC50: 0.170nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in CHO cell membranes after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328388BDBM328388(US9663498, Example 28 | 3-(difluoromethyl)-5-bromo...)
Affinity DataIC50: 0.200nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328379BDBM328379(US9663498, Example 19 | 6-chloro-1-((4-methoxy-3-(...)
Affinity DataIC50: 0.210nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328386BDBM328386(US9663498, Example 26 | 5-chloro-3-(difluoromethyl...)
Affinity DataIC50: 0.220nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 111790BDBM111790(US8618114, 1.2.22(5).HCl)
Affinity DataIC50: 0.227nMAssay Description:Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2014
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328401BDBM328401(US9663498, Example 46 | 3-(difluoromethyl)-1-((3-(...)
Affinity DataIC50: 0.25nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328389BDBM328389(US9663498, Example 29 | 3-(difluoromethyl)-6-fluor...)
Affinity DataIC50: 0.260nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50156201BDBM50156201(CHEMBL3781323)
Affinity DataIC50: 0.280nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in CHO cell membranes after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 111771BDBM111771(US8618114, 1.2.11(1))
Affinity DataIC50: 0.293nMAssay Description:Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2014
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50156209BDBM50156209(CHEMBL3780579)
Affinity DataIC50: 0.310nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in CHO cell membranes after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328393BDBM328393(US9663498, Example 33 | 3-(difluoromethyl)-6-bromo...)
Affinity DataIC50: 0.330nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50417932BDBM50417932(CHEMBL1668587 | US8618114, 1.2.4(1))
Affinity DataIC50: 0.340nMAssay Description:Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2014
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 103506BDBM103506(CHEMBL2172186 | US8552017, 1.1(3).HCl)
Affinity DataKi:  0.389nM IC50: 0.837nMAssay Description:The screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out b the method of radio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2014
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328399BDBM328399(US9663498, Example 44 | 3-(difluoromethyl)-1-((4-m...)
Affinity DataIC50: 0.400nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328402BDBM328402(US9663498, Example 47 | 1-((3-(4-cyclopropylpipera...)
Affinity DataIC50: 0.400nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50158027BDBM50158027(4-[5-Methoxy-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-i...)
Affinity DataIC50: 0.400nMAssay Description:Inhibitory concentration against 5-HT stimulated cAMP production in HeLa cells stably transfected with human 5-HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328366BDBM328366(US9663498, Example 6 | 4-fluoro-1-((4-methoxy-3-(4...)
Affinity DataIC50: 0.430nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328408BDBM328408(US9663498, Example 58 | 5-fluoro-1-((4-methoxy-3-(...)
Affinity DataIC50: 0.430nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50314762BDBM50314762(US8629154, 1.2(3) | 5-methyl-2-(methylthio)-3-(phe...)
Affinity DataKi:  0.440nM ΔG°:  -13.0kcal/mole IC50: 0.948nMpH: 7.4 T: 2°CAssay Description:Determination of tested compounds binding with 5-HT6 receptors was carried out according to the method described in [Monsma F J Jr, Shen Y, Ward R P,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2014
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328412BDBM328412(US9663498, Example 71 | 6-chloro-3-ethyl-1-((4-met...)
Affinity DataIC50: 0.450nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50314759BDBM50314759(US8629154, 1.1(1) | CHEMBL1091206 | 2-(methylthio)...)
Affinity DataKi:  0.458nM ΔG°:  -12.9kcal/mole IC50: 0.986nMpH: 7.4 T: 2°CAssay Description:Determination of tested compounds binding with 5-HT6 receptors was carried out according to the method described in [Monsma F J Jr, Shen Y, Ward R P,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2014
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50156226BDBM50156226(CHEMBL3781452)
Affinity DataIC50: 0.460nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in CHO cell membranes after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328383BDBM328383(US9663498, Example 23 | 3-(difluoromethyl)-5-fluor...)
Affinity DataIC50: 0.460nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328398BDBM328398(US9663498, Example 41 | 6-chloro-1-((3-(4-cyclobut...)
Affinity DataIC50: 0.5nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50156199BDBM50156199(CHEMBL3779904)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in CHO cell membranes after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328404BDBM328404(US9663498, Example 49 | 5,6-dichloro-3-(difluorome...)
Affinity DataIC50: 0.540nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50314760BDBM50314760(CHEMBL1091207 | US8629154, 1.2(1) | 2-(methylthio)...)
Affinity DataKi:  0.549nM ΔG°:  -12.8kcal/mole IC50: 1.18nMpH: 7.4 T: 2°CAssay Description:Determination of tested compounds binding with 5-HT6 receptors was carried out according to the method described in [Monsma F J Jr, Shen Y, Ward R P,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2014
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328387BDBM328387(US9663498, Example 27 | 5-bromo-3-(difluoromethyl)...)
Affinity DataIC50: 0.550nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 111787BDBM111787(US8618114, 1.2.22(2).HCl)
Affinity DataIC50: 0.560nMAssay Description:Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2014
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328382BDBM328382(US9663498, Example 22 | 7-fluoro-1-((4-methoxy-3-(...)
Affinity DataIC50: 0.570nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328407BDBM328407(US9663498, Example 57 | 6-bromo-3-(difluoromethyl)...)
Affinity DataIC50: 0.580nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328362BDBM328362(US9663498, Example 2 | 1-((4-methoxy-3-(4-methylpi...)
Affinity DataIC50: 0.590nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328413BDBM328413(US9663498, Example 72 | 6-bromo-3-ethyl-1-((4-meth...)
Affinity DataIC50: 0.600nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50169599BDBM50169599(CHEMBL194307 | CHEMBL187865 | 1-Benzenesulfonyl-3-...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of cAMP production in HeLa cells expressing human 5-HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328411BDBM328411(US9663498, Example 70 | 3-ethyl-6-fluoro-1-((4-met...)
Affinity DataIC50: 0.630nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328385BDBM328385(US9663498, Example 25 | 5-chloro-3-(difluoromethyl...)
Affinity DataIC50: 0.640nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 111788BDBM111788(US8618114, 1.2.22(3).HCl)
Affinity DataIC50: 0.645nMAssay Description:Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2014
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 103505BDBM103505(CHEMBL2172193 | US8552017, 2(4).HCl)
Affinity DataKi:  0.662nM IC50: 1.43nMAssay Description:The screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out b the method of radio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2014
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 328378BDBM328378(US9663498, Example 18 | 6-fluoro-1-((4-methoxy-3-(...)
Affinity DataIC50: 0.670nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

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