Compile Data Set for Download or QSAR
Report error Found 4922 of ki data for polymerid = 2142
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044610BDBM50044610(CHEMBL3329438)
Affinity DataKi:  0.0400nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166333BDBM166333(US9067949, 190)
Affinity DataKi:  0.0500nM ΔG°:  -14.0kcal/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50415991BDBM50415991(CHEMBL1084794)
Affinity DataKi:  0.0501nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477491BDBM50477491(CHEMBL398034)
Affinity DataKi:  0.0631nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50415975BDBM50415975(CHEMBL1085462)
Affinity DataKi:  0.0631nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50415981BDBM50415981(CHEMBL1086326)
Affinity DataKi:  0.0794nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166213BDBM166213(US9067949, 70)
Affinity DataKi:  0.0830nM ΔG°:  -13.7kcal/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 328391BDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataKi:  0.0850nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318625BDBM50318625(N-Methyl-(3-phenylsulfonyl)-7,8-dihydro-6H-cyclope...)
Affinity DataKi:  0.0880nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50415993BDBM50415993(CHEMBL1086252)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50416007BDBM50416007(CHEMBL1085120)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50416028BDBM50416028(CHEMBL1085658)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166328BDBM166328(US9067949, 185)
Affinity DataKi:  0.100nM ΔG°:  -13.6kcal/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163035BDBM50163035(5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic aci...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of [3H]LSD binding to human 5-hydroxytryptamine 6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50579331BDBM50579331(CHEMBL4852099)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO-K1 cell membranes incubated for 1 hr by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50416015BDBM50416015(CHEMBL1086113)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166303BDBM166303(US9067949, 160)
Affinity DataKi:  0.110nM ΔG°:  -13.6kcal/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166331BDBM166331(US9067949, 188)
Affinity DataKi:  0.110nM ΔG°:  -13.6kcal/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166358BDBM166358(US9067949, 215)
Affinity DataKi:  0.110nM ΔG°:  -13.6kcal/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50001524BDBM50001524(CHEMBL24474)
Affinity DataKi:  0.110nMAssay Description:Binding constant towards serotonin receptor subtype 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]LSD as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318626BDBM50318626(N-Methyl-(3-phenylsulfonyl)-6,7,8,9-tetrahydropyra...)
Affinity DataKi:  0.112nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166197BDBM166197(US9067949, 54)
Affinity DataKi:  0.120nM ΔG°:  -13.5kcal/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50416006BDBM50416006(CHEMBL1083886)
Affinity DataKi:  0.126nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50415996BDBM50415996(CHEMBL1085037)
Affinity DataKi:  0.126nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50416012BDBM50416012(CHEMBL1084711)
Affinity DataKi:  0.126nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166244BDBM166244(US9067949, 143 | US9067949, 101)
Affinity DataKi:  0.130nM ΔG°:  -13.5kcal/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166244BDBM166244(US9067949, 143 | US9067949, 101)
Affinity DataKi:  0.130nM ΔG°:  -13.5kcal/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50001832BDBM50001832(CHEMBL365569)
Affinity DataKi:  0.130nMAssay Description:Binding affinity for human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2014
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166310BDBM166310(US9067949, 167)
Affinity DataKi:  0.130nM ΔG°:  -13.5kcal/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50001827BDBM50001827(CHEMBL363792)
Affinity DataKi:  0.130nMAssay Description:Binding affinity for human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2014
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50358778BDBM50358778(CHEMBL1922616)
Affinity DataKi:  0.140nMAssay Description:Inhibition of human recombinant 5-HT6 receptor expressed in human HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166225BDBM166225(US9067949, 81a | US9067949, 82b | US9067949, 82a)
Affinity DataKi:  0.150nM ΔG°:  -13.4kcal/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50415978BDBM50415978(CHEMBL1086323)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50416000BDBM50416000(CHEMBL1085585)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50415972BDBM50415972(CHEMBL1086079)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50415987BDBM50415987(CHEMBL1085617)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50416019BDBM50416019(CHEMBL1084336)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477488BDBM50477488(CHEMBL394690)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50492797BDBM50492797(CHEMBL2413990)
Affinity DataKi:  0.160nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166326BDBM166326(US9067949, 183)
Affinity DataKi:  0.160nM ΔG°:  -13.4kcal/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166327BDBM166327(US9067949, 184)
Affinity DataKi:  0.160nM ΔG°:  -13.4kcal/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166193BDBM166193(US9067949, 50)
Affinity DataKi:  0.170nM ΔG°:  -13.3kcal/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166335BDBM166335(US9067949, 192)
Affinity DataKi:  0.170nM ΔG°:  -13.3kcal/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318633BDBM50318633(SB-742457 | 3-benzenesulfonyl-8-piperazin-1-ylquin...)
Affinity DataKi:  0.170nMAssay Description:Binding affinity to 5-HT6 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318633BDBM50318633(SB-742457 | 3-benzenesulfonyl-8-piperazin-1-ylquin...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 1 hr by scintillation spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592784BDBM50592784(CHEMBL5177311)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50417934BDBM50417934(CHEMBL1668590 | US8829009, 1.1(7))
Affinity DataKi:  0.186nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166311BDBM166311(US9067949, 168)
Affinity DataKi:  0.190nM ΔG°:  -13.3kcal/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166306BDBM166306(US9067949, 163)
Affinity DataKi:  0.190nM ΔG°:  -13.3kcal/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50001843BDBM50001843(CHEMBL373322)
Affinity DataKi:  0.200nMAssay Description:Binding affinity for human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2014
Entry Details Article
PubMed
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