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TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM21489(MLN4760 | (2S)-2-{[(1S)-1-carboxy-2-{1-[(3,5-dichl...)
Affinity DataIC50: 0.440nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM21489(MLN4760 | (2S)-2-{[(1S)-1-carboxy-2-{1-[(3,5-dichl...)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of ACE2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM21489(MLN4760 | (2S)-2-{[(1S)-1-carboxy-2-{1-[(3,5-dichl...)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of ACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM429241(med.21724, Compound 13)
Affinity DataIC50: 0.440nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624144(CHEMBL5430631)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624143(CHEMBL5394399)
Affinity DataIC50: 0.640nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624145(CHEMBL5406655)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624146(CHEMBL5424883)
Affinity DataIC50: 0.780nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50421866(CHEMBL5281591)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant ACE2 at 50 uM using (7Mca-Y-V-A- D -A-P- K(Knp) as a flurogenic substrate measured after 10 mins by fluorescence base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM429137(med.21724, Compound 10)
Affinity DataIC50: 1nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50606668(CHEMBL5220314)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human ACE2 using 7-Mca-YVADAPK (Dnp) as substrate by fluorescence plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM21488((2S)-2-{[(1S)-1-carboxy-2-{1-[(3,5-dimethylphenyl)...)
Affinity DataIC50: 1.40nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624129(CHEMBL5395954)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate at 25 degreeC incubated for 24 hrs with enzyme followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50421871(CHEMBL5273921)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of SARS-CoV S binding to human recombinant ACE2 expressed in Escherichia coli BL21(DE3) incubated for 2 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624129(CHEMBL5395954)
Affinity DataIC50: 2nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate at 25 degreeC incubated for 0.25 hrs with enzyme followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624129(CHEMBL5395954)
Affinity DataIC50: 2nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624130(CHEMBL5403774)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624136(CHEMBL5429094)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50606669(CHEMBL5220968)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human ACE2 using 7-Mca-YVADAPK (Dnp) as substrate by fluorescence plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624152(CHEMBL5415414)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624149(CHEMBL5424641)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM21486((2S)-2-{[(1S)-1-carboxy-2-{1-[(3-methylphenyl)meth...)
Affinity DataIC50: 4.20nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50421869(CHEMBL5277148)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of SARS-CoV S binding to human recombinant ACE2 expressed in Escherichia coli BL21(DE3) incubated for 2 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624150(CHEMBL5429562)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624131(CHEMBL5396932)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50582780(CHEMBL5091821)
Affinity DataIC50: 6nMAssay Description:Inhibition of SARS-COV2 S-RBD binding to human ACE2 expressed in HEK293T cells using FMZ as substrate by NanoLuc luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50421870(CHEMBL5281306)
Affinity DataIC50: 7nMAssay Description:Inhibition of SARS-CoV S binding to human recombinant ACE2 expressed in Escherichia coli BL21(DE3) incubated for 2 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624137(CHEMBL5433480)
Affinity DataIC50: 7nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50582782(CHEMBL5088125)
Affinity DataIC50: 9nMAssay Description:Inhibition of SARS-COV2 S-RBD binding to human ACE2 expressed in HEK293T cells using FMZ as substrate by NanoLuc luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM21489(MLN4760 | (2S)-2-{[(1S)-1-carboxy-2-{1-[(3,5-dichl...)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of recombinant human ACE2 using 7-Mca-YVADAPK (Dnp) as substrate by fluorescence plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50651540(CHEMBL5631254)
Affinity DataIC50: 10nMAssay Description:Inhibition of human ACE2 using Mca-APK(Dnp) as substrate incubated for 30 mins by fluorometer analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM21491((2S)-2-{[(1S)-1-carboxy-2-[1-(2-cyclohexylpropan-2...)
Affinity DataIC50: 10nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM21487((2S)-2-{[(1S)-1-carboxy-2-{1-[(3,4-dimethylphenyl)...)
Affinity DataIC50: 10nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624138(CHEMBL5434946)
Affinity DataIC50: 10nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50233797(DX-600 | CHEMBL436639)
Affinity DataIC50: 10nMAssay Description:Inhibition of ACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50582783(CHEMBL5093610)
Affinity DataIC50: 10nMAssay Description:Inhibition of SARS-COV2 S-RBD binding to human ACE2 expressed in HEK293T cells using FMZ as substrate by NanoLuc luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50422743(CHEMBL5275219)
Affinity DataIC50: 10nMAssay Description:Inhibition of human ACE2 (unknown origin) at 0.5 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624148(CHEMBL5400018)
Affinity DataIC50: 11nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50582778(CHEMBL5081268)
Affinity DataIC50: 11nMAssay Description:Inhibition of SARS-COV2 S-RBD binding to human ACE2 expressed in HEK293T cells using FMZ as substrate by NanoLuc luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624151(CHEMBL5397691)
Affinity DataIC50: 12nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624139(CHEMBL5420290)
Affinity DataIC50: 13nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624147(CHEMBL5437403)
Affinity DataIC50: 17nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50582779(CHEMBL5081573)
Affinity DataIC50: 18nMAssay Description:Inhibition of SARS-COV2 S-RBD binding to human ACE2 expressed in HEK293T cells using FMZ as substrate by NanoLuc luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM21482((2S)-2-{[(1S)-1-carboxy-2-{1-[(4-chlorophenyl)meth...)
Affinity DataIC50: 21nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM21484((2S)-2-{[(1S)-1-carboxy-2-{1-[(4-methylphenyl)meth...)
Affinity DataIC50: 32nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50582781(CHEMBL5078837)
Affinity DataIC50: 32nMAssay Description:Inhibition of SARS-COV2 S-RBD binding to human ACE2 expressed in HEK293T cells using FMZ as substrate by NanoLuc luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624142(CHEMBL5429801)
Affinity DataIC50: 39nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50651537(CHEMBL5632620)
Affinity DataIC50: 40nMAssay Description:Inhibition of human ACE2 using Mca-APK(Dnp) as substrate incubated for 30 mins by fluorometer analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM50624133(CHEMBL5415513)
Affinity DataIC50: 47nMAssay Description:Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence ba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Millennium Pharmaceuticals

LigandPNGBDBM21483((2S)-2-{[(1S)-1-carboxy-2-(1-{[4-(trifluoromethoxy...)
Affinity DataIC50: 52nMpH: 6.5 T: 2°CAssay Description:Enzyme assay was conducted in 384-well microplates format. Activity was monitored by measuring increase in fluorescence (excitation @320 nm, emission...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
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