Affinity DataIC50: 0.200nMAssay Description:Inhibition of HPGDSMore data for this Ligand-Target Pair
Affinity DataIC50: 2.34nMAssay Description:Inhibition of human recombinant HPGDS using PGH2 as substrate assessed as production of PGD2 preincubated for 10 mins prior substrate addition measur...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 3nMAssay Description:Inhibition of HPGDS (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 8.0 T: 2°CAssay Description:The assay is carried out by the following steps: 1. Inhibitor screening is performed in 100 mM Tris-HCl, pH 8.0 containing 1 mM GSH, 1 mM MgCl.sub.2,...More data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Inhibition of HPGDS (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of human HPGDS assessed as reduction in PGD2 formation using PGH2 as substrate by mass spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of HPGDS (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6nMpH: 8.0 T: 2°CAssay Description:The assay is carried out by the following steps: 1. Inhibitor screening is performed in 100 mM Tris-HCl, pH 8.0 containing 1 mM GSH, 1 mM MgCl.sub.2,...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of HPGDS (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.10nMAssay Description:Inhibition of HPGDS (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.20nMAssay Description:Inhibition of HPGDS (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Inhibition of HPGDS (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of HPGDS (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of human HPGDS assessed as reduction in PGD2 formation using PGH2 as substrate by mass spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 8.20nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
Affinity DataIC50: 8.26nMAssay Description:Inhibition of human recombinant HPGDS using PGH2 as substrate assessed as production of PGD2 preincubated for 10 mins prior substrate addition measur...More data for this Ligand-Target Pair
Affinity DataIC50: 8.90nMAssay Description:Inhibition of HPGDS (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of human HPGDS assessed as reduction in PGD2 formation using PGH2 as substrate by mass spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 9.5nMAssay Description:Inhibition of HPGDS (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 9.70nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
Affinity DataIC50: 9.90nMAssay Description:Inhibition of HPGDS (unknown origin) assessed as reduction in reduction in LPS-induced PGD2 level by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 9.90nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HPGDS (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human HPGDS assessed as reduction in PGD2 formation using PGH2 as substrate by mass spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMpH: 7.4Assay Description:I. Assay Solutions a. Preparation of 0.1M K2HPO4/KH2PO4 buffer (pH 7.4) Prepare 0.1 M KH2PO4 from 1M KH2PO4 (Sigma, Cat# P-8709) ...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of HPGDS (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of HPGDS (unknown origin) assessed as reduction in reduction in LPS-induced PGD2 level by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMpH: 7.4Assay Description:I. Assay Solutions a. Preparation of 0.1M K2HPO4/KH2PO4 buffer (pH 7.4) Prepare 0.1 M KH2PO4 from 1M KH2PO4 (Sigma, Cat# P-8709) ...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMpH: 8.0 T: 2°CAssay Description:The assay is carried out by the following steps: 1. Inhibitor screening is performed in 100 mM Tris-HCl, pH 8.0 containing 1 mM GSH, 1 mM MgCl.sub.2,...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of human HPGDS assessed as reduction in PGD2 formation using PGH2 as substrate by mass spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of HPGDS (unknown origin) assessed as reduction in reduction in LPS-induced PGD2 level by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of HPGDS (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMpH: 8.0Assay Description:The test was carried out according to the method of Urade, Y. et al. (J. Biol. Chem., 262, 3820-3825, (1987)). More specifically, the reaction mixtur...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human HPGDS assessed as reduction in PGD2 formation using PGH2 as substrate by mass spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human HPGDS assessed as reduction in PGD2 formation using PGH2 as substrate by mass spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of HPGDS (unknown origin) assessed as reduction in reduction in LPS-induced PGD2 level by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMpH: 8.0 T: 2°CAssay Description:The assay is carried out by the following steps: 1. Inhibitor screening is performed in 100 mM Tris-HCl, pH 8.0 containing 1 mM GSH, 1 mM MgCl.sub.2,...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMpH: 7.2 T: 2°CAssay Description:The PGDS glutathione-S-transferase (GST) activity was measured by using MonoChloroBimane (MCB) as a chromogenic substrate. The assay was run at 384-w...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of HPGDS (unknown origin) assessed as reduction in reduction in LPS-induced PGD2 level by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of HPGDS (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 23nMpH: 8.0 T: 2°CAssay Description:The assay is carried out by the following steps: 1. Inhibitor screening is performed in 100 mM Tris-HCl, pH 8.0 containing 1 mM GSH, 1 mM MgCl.sub.2,...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition human HPGDS expressed in Escherichia coli assessed as reduction in GST enzymatic activity using MCBL and glutathione incubated for 30 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human HPGDSMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of HPGDS (unknown origin) assessed as reduction in reduction in LPS-induced PGD2 level by ELISAMore data for this Ligand-Target Pair
