Compile Data Set for Download or QSAR
Report error Found 4958 of ic50 for UniProtKB: Q92793
TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM662966(US20240109879, Compound 2B)
Affinity DataIC50: 0.670nMAssay Description:Reagent:Reaction buffer: 25 mM HEPES, pH 7.5, 25 mM NaCl, 0.025% CHAPS, 0.025% BSA, 0.5% DMSO.Ligand:Histone H4 (1-21) K5/8/12/16Ac-GG-Biotin.Standar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM662967(US20240109879, Compound 3B)
Affinity DataIC50: 0.670nMAssay Description:Reagent:Reaction buffer: 25 mM HEPES, pH 7.5, 25 mM NaCl, 0.025% CHAPS, 0.025% BSA, 0.5% DMSO.Ligand:Histone H4 (1-21) K5/8/12/16Ac-GG-Biotin.Standar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM537094(US11247989, Example 92)
Affinity DataIC50: 0.760nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM50453957(CHEMBL4217213)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant His-tagged CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM537100(US11247989, Example 93)
Affinity DataIC50: 0.910nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM50269847(CHEMBL4097025)
Affinity DataIC50: 0.940nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM536872(1-(1-acetylpiperidin-4-yl)-N-methyl-3-(3-(2-methyl...)
Affinity DataIC50: 0.970nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM50453949(CHEMBL4208820 | US11247989, Example 87)
Affinity DataIC50: 0.997nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM340748(US9763922, Example 274)
Affinity DataIC50: 1nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM537101(US11247989, Example 94)
Affinity DataIC50: 1nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM511377(3-(4,4- difluorocyclohexyl)-N- methyl-1-(2-(1-meth...)
Affinity DataIC50: 1nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM340734(US9763922, Example 260 | 3-[5-(difluoromethyl)-2-f...)
Affinity DataIC50: 1nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM511322(3-Cyclopropyl-N-methyl-1-(3-(2-methylthiazol-5-yl)...)
Affinity DataIC50: 1nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM511390(US11058688, Example 89 | US11058688, Example 95 | ...)
Affinity DataIC50: 1nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM50269848(CHEMBL4069831)
Affinity DataIC50: 1nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMed
TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM511316(3-Cyclopropyl-N-methyl-1-(3-(6-(methylcarbamoyl)py...)
Affinity DataIC50: 1nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM511356(N-methyl-1-(3-(6- (methylcarbamoyl)pyridin- 3-yl)i...)
Affinity DataIC50: 1nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM511394(US11058688, Example 93 | 3-(4,4- difluorocyclohexy...)
Affinity DataIC50: 1nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM50269857(CHEMBL4088793)
Affinity DataIC50: 1nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM50616185(CHEMBL5438086)
Affinity DataIC50: 1nMAssay Description:Inhibition of CBP (unknown origin) biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr in presence of acetyl-coA by AlphaLISA ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM536819(3-(6-(difluoromethyl)-7-(1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 1.07nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM50269849(CHEMBL4076748)
Affinity DataIC50: 1.10nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM537087(US11247989, Example 90)
Affinity DataIC50: 1.10nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM536735(US11247989, Example 9)
Affinity DataIC50: 1.13nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM536741(US11247989, Example 10)
Affinity DataIC50: 1.15nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM50453950(CHEMBL4203082 | US11247989, Example 88)
Affinity DataIC50: 1.16nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM537088(US11247989, Example 91)
Affinity DataIC50: 1.17nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM50269855(CHEMBL4061161)
Affinity DataIC50: 1.20nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM50453950(CHEMBL4203082 | US11247989, Example 88)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant His-tagged CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM50269856(CHEMBL4060566)
Affinity DataIC50: 1.20nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM50453949(CHEMBL4208820 | US11247989, Example 87)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant His-tagged CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM536862((S)-1-(3-(6-(1-methyl-1H-pyrazol-4-yl)naphthalen-1...)
Affinity DataIC50: 1.39nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM50269850(CHEMBL4061600)
Affinity DataIC50: 1.40nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM536875(2-cyano-N-methyl-3-(3-(1-methyl-1H-pyrazol-4-yl)is...)
Affinity DataIC50: 1.42nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM536860(N-methyl-3-(4-methyl-3-(1-methyl-1H-pyrazol-4-yl)i...)
Affinity DataIC50: 1.45nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM50269907(CHEMBL4080905)
Affinity DataIC50: 1.5nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM50602881(CHEMBL5204688)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of His6-tagged human CBP bromodomain (1081 to 1197 residues) expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM50269914(CHEMBL4083416)
Affinity DataIC50: 1.5nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM536871(N-methyl-3-(3-(2-methylthiazol-5-yl)isoquinolin-8-...)
Affinity DataIC50: 1.54nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM536857(1-(3-(6-ethyl-3-(1-methyl-1H-pyrazol-4-yl)isoquino...)
Affinity DataIC50: 1.71nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM537149(US11247989, Example 129)
Affinity DataIC50: 1.85nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM50602873(CHEMBL5191045)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of His6-tagged human CBP bromodomain (1081 to 1197 residues) expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM536873(3-isopropyl-N-methyl-1-(3-(1-methyl-1H-pyrazol-4-y...)
Affinity DataIC50: 1.91nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM537086(US11247989, Example 89)
Affinity DataIC50: 1.92nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM511386(US11058688, Example 87 | US11058688, Example 124 |...)
Affinity DataIC50: 2nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM340716(US9763922, Example 242 | 1-[3-[5-(difluoromethyl)-...)
Affinity DataIC50: 2nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM448659(US10696655, Example 125 | 3-(7-(difluoromethyl)-6-...)
Affinity DataIC50: 2nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM511394(US11058688, Example 93 | 3-(4,4- difluorocyclohexy...)
Affinity DataIC50: 2nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM50250892(CHEMBL4061254 | US10696655, Example 63 | US1116807...)
Affinity DataIC50: 2nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Medshine Discovery

US Patent
LigandPNGBDBM448593(US10696655, Example 64 | 5-(7-(difluoromethyl)-6-(...)
Affinity DataIC50: 2nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

Displayed 1 to 50 (of 4958 total ) | Next | Last >>
Jump to: