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TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM87369(US9694016, 704 | US10245267, Example 704 | US10709...)
Affinity DataIC50: 0.0200nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM87369(US9694016, 704 | US10245267, Example 704 | US10709...)
Affinity DataIC50: 0.0200nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM87369(US9694016, 704 | US10245267, Example 704 | US10709...)
Affinity DataIC50: 0.0200nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM25619((1Z)-5-[1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]...)
Affinity DataIC50: 0.0200nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50006650(CHEMBL526479)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of BRAF (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM25636((1Z)-5-[1-(piperidin-4-yl)-3-(pyridin-4-yl)-1H-pyr...)
Affinity DataIC50: 0.0300nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50481591(CHEMBL5289891)
Affinity DataIC50: 0.0340nMAssay Description:Inhibition of B-RAF V600E mutant (unknown origin) expressed in HEK293 cells in presence of tracer incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM25625((1S,3R)-3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H...)
Affinity DataIC50: 0.0400nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM435718(US10570155, Compound 2II | US11332479, Compound 2I...)
Affinity DataIC50: 0.0400nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM435718(US10570155, Compound 2II | US11332479, Compound 2I...)
Affinity DataIC50: 0.0400nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM25629(3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataIC50: 0.0500nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM554464(US11332479, Compound 50III)
Affinity DataIC50: 0.0500nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM186829(US9670203, Compound 1.21)
Affinity DataIC50: 0.0660nMAssay Description:Inhibition of B-RAF V600E mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50585092(CHEMBL5087577)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM554470(US11332479, Compound 72IV)
Affinity DataIC50: 0.0800nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103683(US8563553, 108)
Affinity DataIC50: 0.0800nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103702(US8563553, 127)
Affinity DataIC50: 0.0800nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM25626((1R,3R)-3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H...)
Affinity DataIC50: 0.0900nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50481593(CHEMBL5287468)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of B-Raf in human A-375 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103684(US8563553, 109)
Affinity DataIC50: 0.100nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103629(US8563553, 54)
Affinity DataIC50: 0.100nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103628(US8563553, 53)
Affinity DataIC50: 0.100nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50026212(CHEMBL1276185)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103681(US8563553, 106)
Affinity DataIC50: 0.100nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50139058(CHEMBL3752213)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) by lantha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103632(US8563553, 57)
Affinity DataIC50: 0.100nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50026207(CHEMBL1276170)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103677(US8563553, 102)
Affinity DataIC50: 0.110nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103699(US8563553, 124)
Affinity DataIC50: 0.110nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50330925(7-(2,6-difluoro-4-((1S,4S)-5-methyl-2,5-diazabicyc...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103723(US8563553, 148)
Affinity DataIC50: 0.120nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103680(US8563553, 105)
Affinity DataIC50: 0.130nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM25628(2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataIC50: 0.130nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103715(US8563553, 140)
Affinity DataIC50: 0.130nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103721(US8563553, 146)
Affinity DataIC50: 0.130nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM554469(US11332479, Compound 70IV)
Affinity DataIC50: 0.150nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM554462(US11332479, Compound 46III)
Affinity DataIC50: 0.150nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM25618((1Z)-5-[3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihy...)
Affinity DataIC50: 0.150nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM202851(US9694016, 829 | US9242969, 204 | US10245267, Exam...)
Affinity DataIC50: 0.152nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM202851(US9694016, 829 | US9242969, 204 | US10245267, Exam...)
Affinity DataIC50: 0.152nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50457452(SB590885 | SB-590885)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of full length human 6His-tagged BRAF V600E mutant expressed in baculovirus infected insect cells co-expressing human CDC37 (1 to 378 resi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM554471(US11332479, Compound 73IV)
Affinity DataIC50: 0.160nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50330905(7-(2,6-difluoro-4-((1S,4S)-5-methyl-2,5-diazabicyc...)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103717(US8563553, 142)
Affinity DataIC50: 0.160nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

LigandPNGBDBM50029085(CHEBI:83405 | GDC-0879 | CHEMBL525191)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of BRAF V600E mutant in human MALME-3M cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103648(US8563553, 73)
Affinity DataIC50: 0.180nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103647(US8563553, 72)
Affinity DataIC50: 0.180nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM103693(US8563553, 118)
Affinity DataIC50: 0.190nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM87803(US9694016, 837 | US10245267, Example 837 | US10709...)
Affinity DataIC50: 0.200nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM221684(US9314464, 5 | US9593100, Compound 5 | US10568884,...)
Affinity DataIC50: 0.200nMAssay Description:The B-Raf kinase activity reaction was started by the addition of 10 μl piper well of 2×ATP (10 μM) diluted in assay buffer. After 3 hours,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

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