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Found 41 of ic50 for UniProtKB: A0A024R2W7
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30185(CHEMBL226403 | Pyrrolopyridine, 16)
Affinity DataIC50:  210nMpH: 7.5 T: 2°CAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50012060(CHEMBL3263640)
Affinity DataIC50:  213nMAssay Description:Inhibition of MAPKAPK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30178(Pyrrolopyridine, 9)
Affinity DataIC50:  660nMpH: 7.5 T: 2°CAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50462709(CHEMBL4245507)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of MAPKAPK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50315888(CHEMBL1090360 | N-(3-(5-(2-(3-morpholinophenylamin...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of MK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30192(Pyrrolopyridine, 23)
Affinity DataIC50:  1.10E+3nMpH: 7.5 T: 2°CAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50582077(CHEMBL5085753)
Affinity DataIC50:  1.48E+3nMAssay Description:Inhibition of MAPKAPK3 (unknown origin) by Z-lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human MAPKAPK3 using KKLNRTLSVA as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM558858(US11370770, Compound 6j)
Affinity DataIC50:  2.30E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM558862(US11370770, Compound 6n)
Affinity DataIC50:  2.90E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  3.55E+3nMAssay Description:Inhibition of human MAPKAPK3 using KKLNRTLSVA as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of MK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM558866(US11370770, Compound 6r)
Affinity DataIC50:  4.10E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50220232((S)-benzyl 4-(5-((2-aminophenyl)carbamoyl)pyridin-...)
Affinity DataIC50:  4.52E+3nMAssay Description:Activity against human MAPK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human recombinant MAPKAPK3 expressed in Sf9 insect cells using [KKLNRTLSVA] as substrate in presence of [33P]-ATP by radiometric hotspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM558865(US11370770, Compound 6q)
Affinity DataIC50:  5.50E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM558863(US11370770, Compound 6o)
Affinity DataIC50:  6.00E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM558864(US11370770, Compound 6p)
Affinity DataIC50:  8.50E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50242737((R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimet...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50401152(CHEMBL2205766)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of MAPK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50499634(CHEMBL3741589)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50135286(CHEMBL3745885)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human MAPKAPK3 using [KKLNRTLSVA] as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human MAPKAPK3 (2 to end residues) using KKLNRTLSVA as substrate incubated for 40 mins in presence of [gamma-33ATP by radio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50429867(CHEMBL2333365)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPKAPK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50509949(CHEMBL4475216 | US11667631, Example 29)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPKAPK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50001733(CHEMBL3133821)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human MAPKAPK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM558867(US11370770, Compound 6s)
Affinity DataIC50:  1.20E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM558848(US11370770, Compound 6a)
Affinity DataIC50:  1.60E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM93224(Kinase inhibitor, A1)
Affinity DataIC50:  2.10E+4nMAssay Description:Selected compounds were screened against a panel of mammalian kinases. Compounds were supplied in DMSO and screened in duplicates at 100 uM concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM558880(US11370770, Compound 6ee)
Affinity DataIC50:  2.10E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50537742(CHEMBL4634634 | US11179389, Compound 1-14)
Affinity DataIC50:  2.35E+4nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM558850(US11370770, Compound 6b)
Affinity DataIC50: >2.70E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Affinity DataIC50: >2.70E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM558875(US11370770, Compound 6z)
Affinity DataIC50: >2.70E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of MAPKAPK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of MAPKAPK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM27344(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)
Affinity DataIC50:  5.77E+4nMpH: 7.5 T: 2°CAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50215481(5-methoxy-9,12-diazatetracyclo[10.2.1.0^{2,10}.0^{...)
Affinity DataIC50:  9.00E+4nMAssay Description:Inhibition of MK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50215497(5-methoxy-9,12-diazatetracyclo[10.3.1.0^{2,10}.0^{...)
Affinity DataIC50:  1.60E+5nMAssay Description:Inhibition of MK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50215483(6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of MK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed