Compile Data Set for Download or QSAR
Report error Found 45 of ec50 for UniProtKB: Q16539
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20655(N-benzyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]a...)
Affinity DataIC50: 0.400nM EC50:  9.60nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20645(ethyl 4-{[5-(methoxycarbamoyl)-2-methylphenyl]amin...)
Affinity DataIC50: 0.900nM EC50:  37nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20650(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)
Affinity DataIC50: 0.900nM EC50:  30nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20640(methyl 4-{[5-(methoxycarbamoyl)-2-methylphenyl]ami...)
Affinity DataIC50: 1.10nM EC50:  160nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20656(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)
Affinity DataIC50: 1.20nM EC50:  2.40nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20666(propan-2-yl N-(4-{[5-(methoxycarbamoyl)-2-methylph...)
Affinity DataIC50: 1.20nM EC50:  110nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20665(ethyl N-(4-{[5-(methoxycarbamoyl)-2-methylphenyl]a...)
Affinity DataIC50: 1.5nM EC50:  26nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20652(N-[(2S)-butan-2-yl]-4-{[5-(methoxycarbamoyl)-2-met...)
Affinity DataIC50: 3nM EC50: <2nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM50303597((S)-2-(2-amino-3-phenylpropylamino)-3-methyl-5-(na...)
Affinity DataEC50:  2.10nMAssay Description:Binding affinity to HiBiT-tagged MAPK14 (unknown origin) assessed as shift in melting/aggregation temperature by luminescence based BiTSA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20653(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-N-(...)
Affinity DataIC50: 2.20nM EC50:  140nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20657(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)
Affinity DataIC50: 2.20nM EC50:  10nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20649(N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]am...)
Affinity DataIC50: 3.10nM EC50:  61nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20664(methyl N-(4-{[5-(methoxycarbamoyl)-2-methylphenyl]...)
Affinity DataIC50: 3.30nM EC50:  100nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20660(3-({6-acetamido-5-methylpyrrolo[1,2-a][1,2,4]triaz...)
Affinity DataIC50: 3.60nM EC50:  190nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20643(methyl 4-{[5-(ethoxycarbamoyl)-2-methylphenyl]amin...)
Affinity DataIC50: 4nM EC50:  380nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20673(ethyl N-(3-{[6-(ethylcarbamoyl)-5-methylpyrrolo[1,...)
Affinity DataIC50: 4.70nM EC50:  72nMAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataEC50:  5.20nMAssay Description:Inhibition of p38 phosphorylation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20668(ethyl N-(4-methyl-3-{[5-methyl-6-(propylcarbamoyl)...)
Affinity DataIC50: 5.5nM EC50:  69nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20675(ethyl N-[3-({6-[(2S)-butan-2-ylcarbamoyl]-5-methyl...)
Affinity DataIC50: 5.60nM EC50:  47nMAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM36476((S)-3-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2...)
Affinity DataEC50: <7nMpH: 9.5 T: 2°CAssay Description:Selection of DNA-encoded libraries (DELs), which are covalent attachment of encoding double stranded DNA to small-molecule created using a combinatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20674(ethyl N-(4-methyl-3-{[5-methyl-6-(propan-2-ylcarba...)
Affinity DataIC50: 7.70nM EC50:  110nMAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20654(N-cyclopentyl-4-{[5-(methoxycarbamoyl)-2-methylphe...)
Affinity DataIC50: 8nM EC50:  43nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM36474((S)-3-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2...)
Affinity DataEC50: <8nMpH: 9.5 T: 2°CAssay Description:Selection of DNA-encoded libraries (DELs), which are covalent attachment of encoding double stranded DNA to small-molecule created using a combinatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20659(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)
Affinity DataIC50: 8nM EC50:  72nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM50303597((S)-2-(2-amino-3-phenylpropylamino)-3-methyl-5-(na...)
Affinity DataEC50:  10nMAssay Description:Binding affinity to MAPK14 (unknown origin) by fluorescence imaging/AlphaLISA based thermal shit assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20651(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)
Affinity DataIC50: 10nM EC50:  41nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20663(N-methoxy-4-methyl-3-({5-methyl-6-[(propan-2-ylcar...)
Affinity DataIC50: 12nM EC50: >2.00E+3nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20661(N-methoxy-4-methyl-3-({5-methyl-6-propanamidopyrro...)
Affinity DataIC50: 13nM EC50:  530nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20662(N-methoxy-4-methyl-3-{[5-methyl-6-(2-methylpropana...)
Affinity DataIC50: 13nM EC50:  120nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20667(methyl N-(4-methyl-3-{[5-methyl-6-(propylcarbamoyl...)
Affinity DataIC50: 15nM EC50:  150nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20671(4-{[5-(2-methoxyacetamido)-2-methylphenyl]amino}-5...)
Affinity DataIC50: 20nM EC50:  43nMAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20648(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-N,5...)
Affinity DataIC50: 23nM EC50:  580nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM50303597((S)-2-(2-amino-3-phenylpropylamino)-3-methyl-5-(na...)
Affinity DataEC50:  35nMAssay Description:Binding affinity to MAPK14 (unknown origin) measured after 5 to 6 hrs incubation by AlphaLISA based thermal shit assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20644(methyl 4-{[5-(methoxycarbamoyl)-2-methylphenyl]ami...)
Affinity DataIC50: 42nM EC50: >2.00E+3nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM50045333(CHEBI:90705 | SB-203580)
Affinity DataEC50:  60nMAssay Description:Inhibition of recombinant Nanoluc-tagged p38alpha (unknown origin) expressed in HEK293 cells incubated for 2 to 3 mins by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20641(methyl 4-[(5-carbamoyl-2-methylphenyl)amino]-5-met...)
Affinity DataIC50: 78nM EC50: >2.00E+3nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20658(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)
Affinity DataIC50: 180nM EC50: >1.00E+3nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20639(methyl 5-methyl-4-{[2-methyl-5-(methylcarbamoyl)ph...)
Affinity DataIC50: 220nM EC50: >5.00E+3nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM36472((S)-3-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2...)
Affinity DataEC50:  250nMpH: 9.5 T: 2°CAssay Description:Selection of DNA-encoded libraries (DELs), which are covalent attachment of encoding double stranded DNA to small-molecule created using a combinatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataEC50:  470nMAssay Description:Inhibition of recombinant Nanoluc-tagged p38alpha (unknown origin) expressed in HEK293 cells incubated for 2 to 3 mins by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM50504170(CHEMBL4553144)
Affinity DataEC50:  520nMAssay Description:Inhibition of recombinant Nanoluc-tagged p38alpha (unknown origin) expressed in HEK293 cells incubated for 2 to 3 mins by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM50504180(CHEMBL4559825)
Affinity DataEC50:  1.94E+3nMAssay Description:Inhibition of recombinant Nanoluc-tagged p38alpha (unknown origin) expressed in HEK293 cells incubated for 2 to 3 mins by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM36473((S)-3-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2...)
Affinity DataEC50:  2.70E+3nMpH: 9.5 T: 2°CAssay Description:Selection of DNA-encoded libraries (DELs), which are covalent attachment of encoding double stranded DNA to small-molecule created using a combinatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM50237710(AMN 107 | AMN107 | 4-methyl-N-[3-(4-methyl-1H-imid...)
Affinity DataEC50:  4.60E+3nMAssay Description:Thermal stabilization of LPS-stimulated P38alpha in human THP-1 cells at 5 uM pretreated for 1 hr followed by LPS-stimulation and measured after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Pharmaceuticals

LigandPNGBDBM36475((S)-3-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2...)
Affinity DataEC50:  5.20E+3nMpH: 9.5 T: 2°CAssay Description:Selection of DNA-encoded libraries (DELs), which are covalent attachment of encoding double stranded DNA to small-molecule created using a combinatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2011
Entry Details Article
PubMed