Compile Data Set for Download or QSAR
Report error Found 8026 of ic50 for UniProtKB: Q16539
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50605778(CHEMBL5186216)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human recombinant full length GST-tagged p38alpha expressed in Escherichia coli preincubated for 2 hrs followed by ATP addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM125994(US8772288, 19)
Affinity DataIC50: 0.0400nMpH: 7.5 T: 2°CAssay Description:Enzymatic activity assay was performed in 96-well microtiter plates (Corning, catalog number #3686) using a total volume of 50 ul of an assay buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2014
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50605782(CHEMBL5174953)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant full length GST-tagged p38alpha expressed in Escherichia coli preincubated for 2 hrs followed by ATP addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50605750(CHEMBL5172781)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant full length GST-tagged p38alpha expressed in Escherichia coli preincubated for 2 hrs followed by ATP addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50605751(CHEMBL5180443)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of human recombinant full length GST-tagged p38alpha expressed in Escherichia coli preincubated for 2 hrs followed by ATP addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50356004(CHEMBL1911339)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of human p38alpha using biotinylated ATF2 as substrate preincubated for 1 hr measured after 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50352566(CHEMBL1825148 | US8772288, 23)
Affinity DataIC50: 0.0600nMpH: 7.5 T: 2°CAssay Description:Enzymatic activity assay was performed in 96-well microtiter plates (Corning, catalog number #3686) using a total volume of 50 ul of an assay buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2014
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM16015(CHEMBL252967 | N-cyclopropyl-4-[4-(3,4-dichlorophe...)
Affinity DataIC50: 0.0780nMpH: 7.0 T: 2°CAssay Description:HTRF relies on fluorescence resonance energy transfer (FRET) between the donor, a europium cryptate (EuK), and the acceptor, the light harvesting pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50605749(CHEMBL5206397)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of human recombinant full length GST-tagged p38alpha expressed in Escherichia coli preincubated for 2 hrs followed by ATP addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50175745(7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophen...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of wild type p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50352565(CHEMBL1825149)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50352566(CHEMBL1825148 | US8772288, 23)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50605781(CHEMBL5202475)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human recombinant full length GST-tagged p38alpha expressed in Escherichia coli preincubated for 2 hrs followed by ATP addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50122385(5-(2-Chloro-phenyl)-1-(2,6-dichloro-phenyl)-7-pipe...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of p38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50175747(7-(1-tert-butylpiperidin-4-yl)-5-(2-chlorophenyl)-...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50605753(CHEMBL5200224)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human recombinant full length GST-tagged p38alpha expressed in Escherichia coli preincubated for 2 hrs followed by ATP addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50122386(5-(2-Chloro-4-fluoro-phenyl)-1-(2,6-dichloro-pheny...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of p38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50241077(CHEMBL4060815)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM15459(4-{1-methyl-2-piperidin-4-yl-4-[3-(trifluoromethyl...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of wild type p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14/1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM719555(3-chloro-4-((1S,2S)-2-(5-chloropyridin-3-yl)cyclop...)
Affinity DataIC50: 0.100nMAssay Description:In a 20 μL reaction, the compounds of various concentrations (20 nL) were pre-incubated with 0.6 nM MK2 (Abcam #ab79910) and 0.06 nM active p38α (Abc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50122385(5-(2-Chloro-phenyl)-1-(2,6-dichloro-phenyl)-7-pipe...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50122387(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50122387(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)
Affinity DataIC50: 0.100nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50122386(5-(2-Chloro-4-fluoro-phenyl)-1-(2,6-dichloro-pheny...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50122386(5-(2-Chloro-4-fluoro-phenyl)-1-(2,6-dichloro-pheny...)
Affinity DataIC50: 0.100nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50122385(5-(2-Chloro-phenyl)-1-(2,6-dichloro-phenyl)-7-pipe...)
Affinity DataIC50: 0.100nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14/1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM719272(3-(3-chloro-3'-fluoro-4-((1S,2S)-2-(5-fluoropyridi...)
Affinity DataIC50: 0.100nMAssay Description:In a 20 μL reaction, the compounds of various concentrations (20 nL) were pre-incubated with 0.6 nM MK2 (Abcam #ab79910) and 0.06 nM active p38α (Abc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50122387(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of p38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50605747(CHEMBL5173417)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human recombinant full length GST-tagged p38alpha expressed in Escherichia coli preincubated for 2 hrs followed by ATP addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15240(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50375790(CHEMBL270004)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50122390(5-(2-Chloro-4-fluoro-phenyl)-1-(2,6-dichloro-pheny...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50122390(5-(2-Chloro-4-fluoro-phenyl)-1-(2,6-dichloro-pheny...)
Affinity DataIC50: 0.130nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50357914(CHEMBL1916528)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of human p38alpha MAP kinase after 1 hr by FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50122390(5-(2-Chloro-4-fluoro-phenyl)-1-(2,6-dichloro-pheny...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of p38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50175745(7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophen...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50219316(CHEMBL545353)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50375797(CHEMBL269792)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50356003(CHEMBL1911338)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of human p38alpha using biotinylated ATF2 as substrate preincubated for 1 hr measured after 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50560252(CHEMBL4764056)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of p38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50122384(5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piper...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of p38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM17060(CHEMBL319556 | 1-(2,6-dichlorophenyl)-5-(2,4-diflu...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of p38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50122379(7-(1-tert-Butyl-piperidin-4-yl)-5-(2-chloro-4-fluo...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of p38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50605780(CHEMBL5198434)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant full length GST-tagged p38alpha expressed in Escherichia coli preincubated for 2 hrs followed by ATP addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50605786(CHEMBL5198371)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant full length GST-tagged p38alpha expressed in Escherichia coli preincubated for 2 hrs followed by ATP addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50605788(CHEMBL5190010)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant full length GST-tagged p38alpha expressed in Escherichia coli preincubated for 2 hrs followed by ATP addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50425360(CHEMBL2316207)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of p38alpha MAP kinase (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50605771(CHEMBL5203796)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant full length GST-tagged p38alpha expressed in Escherichia coli preincubated for 2 hrs followed by ATP addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50348312(CHEMBL1800222 | US8772288, 12)
Affinity DataIC50: 0.200nMpH: 7.5 T: 2°CAssay Description:Enzymatic activity assay was performed in 96-well microtiter plates (Corning, catalog number #3686) using a total volume of 50 ul of an assay buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2014
Entry Details
US Patent

Displayed 1 to 50 (of 8026 total ) | Next | Last >>
Jump to: