Compile Data Set for Download or QSAR
Report error Found 475 of kd for UniProtKB: Q16539
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50361467(CHEMBL1938400)
Affinity DataKd:  0.00100nMAssay Description:Binding affinity to human p38alpha MAPK by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314789(N-cyclopropyl-3-(1-(2-fluorophenyl)phthalazin-6-yl...)
Affinity DataKd:  0.0500nMAssay Description:Binding affinity to p38alpha by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM14839(BIRB-796 Analog 33 | 3-(3-tert-butyl-1-phenyl-1H-p...)
Affinity DataKd:  0.0900nMpH: 7.0 T: 2°CAssay Description:The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM14839(BIRB-796 Analog 33 | 3-(3-tert-butyl-1-phenyl-1H-p...)
Affinity DataKd:  0.0970nMAssay Description:Binding affinity for Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  0.0980nMAssay Description:Binding affinity to full-length GST-tagged p38alpha by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  0.0980nMAssay Description:Rate of dissociation from Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  0.100nMpH: 7.0 T: 2°CAssay Description:The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM14839(BIRB-796 Analog 33 | 3-(3-tert-butyl-1-phenyl-1H-p...)
Affinity DataKd:  0.100nMAssay Description:Binding affinity to P38 mitogen activated protein kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  0.100nMAssay Description:Binding affinity to p38alpha by exchange curve binding kinetic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  0.100nMpH: 7.0 T: 2°CAssay Description:The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  0.123nMAssay Description:Binding affinity to wild type human biotin labelled p38 alpha (9 to 352 residues) expressed in sf21 insect cells SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  0.160nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314790(N-Cyclopropyl-3-(1-(2-fluorophenyl)-7-methyl-6-oxo...)
Affinity DataKd:  0.180nMAssay Description:Binding affinity to p38alpha by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50341342(6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-...)
Affinity DataKd:  0.200nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105748({4-[5-(4-Fluoro-phenyl)-3-piperidin-4-yl-3H-imidaz...)
Affinity DataKd:  0.230nMAssay Description:D3R2023More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  0.240nMAssay Description:Average Binding Constant for p38-alpha; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314776(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataKd:  0.25nMAssay Description:Binding affinity to p38alpha by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50341345(6-(2-Chlorophenyl)-8-methyl-2-(tetrahydro-2H-pyran...)
Affinity DataKd:  0.300nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314780(N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to P38alpha MAPK (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314780(N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataKd:  0.310nMAssay Description:Binding affinity to p38alpha by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105748({4-[5-(4-Fluoro-phenyl)-3-piperidin-4-yl-3H-imidaz...)
Affinity DataKd:  0.330nMAssay Description:D3R2023More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  0.370nMAssay Description:Binding constant for full-length p38-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50361468(CHEMBL1938736)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to p38alpha MAPK by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  0.450nMAssay Description:Binding constant for p38-alpha kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50503388(CHEMBL4521096)
Affinity DataKd:  0.470nMAssay Description:Binding affinity to wild-type human full length p38-alpha (M1 to S360 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50099333(2-(3,5-Dimethyl-phenoxy)-4-[5-(4-fluoro-phenyl)-3-...)
Affinity DataKd:  0.470nMAssay Description:Binding affinity to p38 alpha (unknown origin) assessed as dissociation constant by DiscoverX kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50503388(CHEMBL4521096)
Affinity DataKd:  0.470nMAssay Description:Binding affinity to human p38alpha (1 to 360 residues) expressed in bacterial expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266947(2-(6-chloro-5-{[(2R,5S)-4-(4-fluorobenzyl)-2,5-dim...)
Affinity DataKd:  0.480nMAssay Description:Binding affinity to p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM14840(BIRB-796 Analog 30 | 3-[3-tert-butyl-1-(4-methylph...)
Affinity DataKd:  0.5nMpH: 7.0 T: 2°CAssay Description:The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  1nMAssay Description:Binding affinity to wild type human biotin labelled p38 alpha (9 to 352 residues) expressed in sf21 insect cells assessed as dissociation rate consta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM14837(BIRB-796 Analog 4 | 3-[3-tert-butyl-1-(4-methylphe...)
Affinity DataKd:  1nMpH: 7.0 T: 2°CAssay Description:The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM142598(US8933228, Ref 2 | US9249125, Reference Compound |...)
Affinity DataKd:  1nMAssay Description:The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM142598(US8933228, Ref 2 | US9249125, Reference Compound |...)
Affinity DataKd:  1nMAssay Description:p38 MAPKα: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344123((R)-6-(2,4-difluorophenoxy)-N-(1-(methylsulfonyl)p...)
Affinity DataKd:  1nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  1nMAssay Description:Binding affinity to p38alpha MAPK by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM14837(BIRB-796 Analog 4 | 3-[3-tert-butyl-1-(4-methylphe...)
Affinity DataKd:  1.10nMAssay Description:Binding affinity for Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM14844(3-[3-tert-butyl-1-(6-methylpyridin-3-yl)-1H-pyrazo...)
Affinity DataKd:  1.10nMAssay Description:Binding affinity for Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241001(CHEMBL4082844)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to wild type human biotin labelled p38 alpha (9 to 352 residues) expressed in sf21 insect cells assessed as dissociation rate consta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50341346((R)-6-(2,4-difluorophenoxy)-8-methyl-2-(1-(methyls...)
Affinity DataKd:  1.20nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132415(1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(3...)
Affinity DataKd:  1.20nMAssay Description:Binding affinity for Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  1.30nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241000(CHEMBL4092372)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to wild type human biotin labelled p38 alpha (9 to 352 residues) expressed in sf21 insect cells SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM586663(D3RKN_53)
Affinity DataKd:  1.30nMAssay Description:D3R2023More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50392175(CHEMBL2152944)
Affinity DataKd:  1.5nMAssay Description:Inhibition of non-phosphorylated human N-terminal His-P38alpha overexpressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by Kino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277615(1-(5-tert-butyl-2-methoxyphenyl)-3-(4-(6-(morpholi...)
Affinity DataKd:  1.80nMAssay Description:Binding affinity to p38alpha by exchange curve binding kinetic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM298446(US10125100, Example 44 | (4-((4-((4-(3-(5-(tert-Bu...)
Affinity DataKd:  1.90nMAssay Description:p38 MAPKα Method 1: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen) are evaluated indirectly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM586495(D3RKN_3)
Affinity DataKd:  1.90nMAssay Description:D3R2023More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50401291(CHEMBL2204527 | D3RKN_13)
Affinity DataKd:  1.90nMAssay Description:D3R2023More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241044(CHEMBL4078249)
Affinity DataKd:  2nMAssay Description:Binding affinity to wild type human biotin labelled p38 alpha (9 to 352 residues) expressed in sf21 insect cells assessed as dissociation rate consta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
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