Compile Data Set for Download or QSAR
Report error Found 4645 of ki for UniProtKB: Q07820
LigandPNGBDBM451126(US10676485, Example 36)
Affinity DataKi:  0.00100nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
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Date in BDB:
3/11/2021
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LigandPNGBDBM451115(US10676485, Example 25)
Affinity DataKi:  0.00300nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
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Date in BDB:
3/11/2021
Entry Details
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LigandPNGBDBM451129(US10676485, Example 39)
Affinity DataKi:  0.00400nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
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Date in BDB:
3/11/2021
Entry Details
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LigandPNGBDBM673751(US20240150293, Example 987 | (1r,4S,4′R,8...)
Affinity DataKi:  0.00400nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
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Date in BDB:
8/9/2024
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LigandPNGBDBM451099(US10676485, Example 9)
Affinity DataKi:  0.00500nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
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Date in BDB:
3/11/2021
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LigandPNGBDBM451104(US10676485, Example 14)
Affinity DataKi:  0.00600nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
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Date in BDB:
3/11/2021
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LigandPNGBDBM50587659(CHEMBL5186095)
Affinity DataKi:  0.00600nMAssay Description:Inhibition of recombinant His6-tagged human MCL1 (171 to 327 residues) expressed in Escherichia coli and biotinylated Bim BH3 peptide interaction usi...More data for this Ligand-Target Pair
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Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM470989(US10821115, Example 100135 | US10821115, Example 1...)
Affinity DataKi:  0.00600nMAssay Description:Inhibition of recombinant His6-tagged human MCL1 (171 to 327 residues) expressed in Escherichia coli and biotinylated Bim BH3 peptide interaction usi...More data for this Ligand-Target Pair
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Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM673652(US20240150293, Example 837 | Example 837A (2E)-3-(...)
Affinity DataKi:  0.00700nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
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Date in BDB:
8/9/2024
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LigandPNGBDBM673748(US20240150293, Example 984 | Example 984A (3R)-but...)
Affinity DataKi:  0.00700nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
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Date in BDB:
8/9/2024
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LigandPNGBDBM451117(US10676485, Example 27)
Affinity DataKi:  0.00800nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
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Date in BDB:
3/11/2021
Entry Details
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LigandPNGBDBM451131(US10676485, Example 41)
Affinity DataKi:  0.00900nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
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Date in BDB:
3/11/2021
Entry Details
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LigandPNGBDBM668469(US20240124487, Compound 9)
Affinity DataKi:  0.00900nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
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LigandPNGBDBM668463(US20240124487, Compound 3 | US20240124487, Compoun...)
Affinity DataKi:  0.00900nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
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LigandPNGBDBM668466(US20240124487, Compound 6)
Affinity DataKi:  0.00900nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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LigandPNGBDBM673736(US20240150293, Example 972 | (1r,3'S,4S,7′S)...)
Affinity DataKi:  0.00900nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
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Date in BDB:
8/9/2024
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LigandPNGBDBM451139(US10676485, Example 49)
Affinity DataKi: <0.0100nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
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Date in BDB:
3/11/2021
Entry Details
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LigandPNGBDBM451141(US10676485, Example 51)
Affinity DataKi: <0.0100nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
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Date in BDB:
3/11/2021
Entry Details
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LigandPNGBDBM451142(US10676485, Example 52)
Affinity DataKi: <0.0100nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
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LigandPNGBDBM668470(US20240124487, Compound 10 | US20240124487, Compou...)
Affinity DataKi:  0.0100nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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LigandPNGBDBM451097(US10676485, Example 7)
Affinity DataKi: <0.0100nMMore data for this Ligand-Target Pair
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Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM668477(US20240124487, Compound 17 | US20240124487, Compou...)
Affinity DataKi:  0.0100nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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LigandPNGBDBM451111(US10676485, Example 21)
Affinity DataKi:  0.0110nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
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Date in BDB:
3/11/2021
Entry Details
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LigandPNGBDBM451119(US10676485, Example 29)
Affinity DataKi:  0.0110nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
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LigandPNGBDBM668465(US20240124487, Compound 5)
Affinity DataKi:  0.0110nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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LigandPNGBDBM673658(US20240150293, Example 844 | Example 844A 3-chloro...)
Affinity DataKi:  0.0110nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
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Date in BDB:
8/9/2024
Entry Details
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LigandPNGBDBM673728(US20240150293, Example 962 | Example 962A methyl (...)
Affinity DataKi:  0.0110nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
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Date in BDB:
8/9/2024
Entry Details
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LigandPNGBDBM668467(US20240124487, Compound 7)
Affinity DataKi:  0.0110nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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LigandPNGBDBM673704(US20240150293, Example 921 | Example 921A methyl (...)
Affinity DataKi:  0.0110nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
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Date in BDB:
8/9/2024
Entry Details
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LigandPNGBDBM685600(US20240239812, Compound 26 | US20240239812, Compou...)
Affinity DataKi:  0.0110nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
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Date in BDB:
10/30/2024
Entry Details
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LigandPNGBDBM685604(US20240239812, Compound 30 | US20240239812, Compou...)
Affinity DataKi:  0.0110nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
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LigandPNGBDBM451135(US10676485, Example 45)
Affinity DataKi:  0.0120nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
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LigandPNGBDBM673737(US20240150293, Example 973 | Example 973A (2S)-pro...)
Affinity DataKi:  0.0120nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
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Date in BDB:
8/9/2024
Entry Details
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LigandPNGBDBM673725(US20240150293, Example 959 | Example 959A methyl (...)
Affinity DataKi:  0.0120nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
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Date in BDB:
8/9/2024
Entry Details
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LigandPNGBDBM470606(US10821115, Example 10 | US11224601, Example 10)
Affinity DataKi:  0.0120nMAssay Description:Inhibition of recombinant His6-tagged human MCL1 (171 to 327 residues) expressed in Escherichia coli and biotinylated Bim BH3 peptide interaction usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM451105(US10676485, Example 15)
Affinity DataKi:  0.0130nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
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Date in BDB:
3/11/2021
Entry Details
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LigandPNGBDBM451137(US10676485, Example 47)
Affinity DataKi:  0.0130nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
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LigandPNGBDBM668486(US20240124487, Compound 27 | US20240124487, Compou...)
Affinity DataKi:  0.0130nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2024
Entry Details
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LigandPNGBDBM668468(US20240124487, Compound 8)
Affinity DataKi:  0.0130nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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LigandPNGBDBM50627197(CHEMBL5396628)
Affinity DataKi:  0.0130nMAssay Description:Displacement of Cy5-labeled BIM BH3 peptide (H3N-(C/Cy5Mal)-WIAQELRRIGDEFN-OH) from MCL-1 (unknown origin) assessed as inhibition constant incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM451130(US10676485, Example 40)
Affinity DataKi:  0.0140nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
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LigandPNGBDBM673735(US20240150293, Example 971 | Example 971A (2R)-pro...)
Affinity DataKi:  0.0140nMAssay Description:The addition of a compound which binds competitively to the same site as the peptide will result in an increase in the fluorescence intensity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
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LigandPNGBDBM685604(US20240239812, Compound 30 | US20240239812, Compou...)
Affinity DataKi:  0.0140nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
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LigandPNGBDBM685582(US20240239812, Compound 6)
Affinity DataKi:  0.0140nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
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Date in BDB:
10/30/2024
Entry Details
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LigandPNGBDBM471064(US10821115, Example 100078 | US10821115, Example 1...)
Affinity DataKi:  0.0140nMAssay Description:Inhibition of recombinant His6-tagged human MCL1 (171 to 327 residues) expressed in Escherichia coli and biotinylated Bim BH3 peptide interaction usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM451120(US10676485, Example 30)
Affinity DataKi:  0.0150nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
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LigandPNGBDBM668472(US20240124487, Compound 12 | US20240124487, Compou...)
Affinity DataKi:  0.0150nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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LigandPNGBDBM50627203(CHEMBL5307201)
Affinity DataKi:  0.0150nMAssay Description:Displacement of Cy5-labeled BIM BH3 peptide (H3N-(C/Cy5Mal)-WIAQELRRIGDEFN-OH) from MCL-1 (unknown origin) assessed as inhibition constant incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM470606(US10821115, Example 10 | US11224601, Example 10)
Affinity DataKi:  0.0150nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM451112(US10676485, Example 22)
Affinity DataKi:  0.0160nMAssay Description:The ability of the exemplary MCL-1 inhibitors of Examples 1 through 151 to bind MCL-1 was demonstrated using the Time Resolved-Fluorescence Resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
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