Compile Data Set for Download or QSAR
Report error Found 78 of ic50 for UniProtKB: Q9UQM7
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.0310nMAssay Description:Inhibition of human CAMK2A using KKALRRQETVDAL as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.0640nMAssay Description:Inhibition of human CAMK2A using KKALRRQETVDAL as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of CamK2alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 2nMAssay Description:Inhibition of Calcium/calmodulin-dependent protein kinase type IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 130909BDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human CAMK2a using KKALRRQETVDAL as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 4nMAssay Description:Inhibition of purified mammalian brain calcium calmodulin dependent protein kinase (Ca calmod)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 6nMAssay Description:Inhibition of Calcium/calmodulin-dependent protein kinase type IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 2672BDBM2672(6,7,12,13-Tetrahydro-5,7-dioxo-5H-indolo[2,3-a]pyr...)
Affinity DataIC50: 25nMAssay Description:Inhibition of Calcium/calmodulin-dependent protein kinase type IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50430016BDBM50430016(CHEMBL2335444)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant full length CAMK2alpha (unknown origin) using autocamtide-2 as substrate assessed as incorporation of 32P after 30 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50217536BDBM50217536(CHEMBL2369378)
Affinity DataIC50: 32nMAssay Description:Inhibitory activity of compound against CaMKIIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50217537BDBM50217537(CHEMBL385035)
Affinity DataIC50: 36nMAssay Description:Inhibitory activity of compound against CaMKIIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2018
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50430015BDBM50430015(CHEMBL2335442)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant full length CAMK2alpha (unknown origin) using autocamtide-2 as substrate assessed as incorporation of 32P after 30 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50430014BDBM50430014(CHEMBL2335479)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant full length CAMK2alpha (unknown origin) using autocamtide-2 as substrate assessed as incorporation of 32P after 30 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 2581BDBM2581(CHEMBL16958 | 3,13,23-triazahexacyclo[14.7.0.0^{2,...)
Affinity DataIC50: 184nMAssay Description:Inhibition of Calcium/calmodulin-dependent protein kinase type IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163748BDBM50163748(4-(2-(5-(4-hydroxy-3-methoxystyryl)-1H-pyrazol-3-y...)
Affinity DataIC50: 290nMAssay Description:Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163745BDBM50163745(4-((E)-2-{3-[(E)-2-(4-hydroxy-3-methoxyphenyl)viny...)
Affinity DataIC50: 680nMAssay Description:Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50132310BDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50: 780nMAssay Description:Inhibition of Calcium/calmodulin-dependent protein kinase type IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50520464BDBM50520464(CHEMBL4556306)
Affinity DataIC50: 790nMAssay Description:Inhibition of human CaMKIIalpha using calmodulin and syntide-2 incubated for 15 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50520463BDBM50520463(CHEMBL4572769)
Affinity DataIC50: 810nMAssay Description:Inhibition of human CaMKIIalpha using calmodulin and syntide-2 incubated for 15 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50520462BDBM50520462(CHEMBL4515601)
Affinity DataIC50: 840nMAssay Description:Inhibition of human CaMKIIalpha using calmodulin and syntide-2 incubated for 15 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50611755BDBM50611755(CHEMBL5281283)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CAMK2alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 174948BDBM174948(US9096593, P-2049 | US20250353857, Compound PLX562...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CAMK2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50217535BDBM50217535(desLys-AIP | CHEMBL425458)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity of compound against CaMKIIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2018
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50095952BDBM50095952(CHEMBL3593777)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CaMK2a (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311017BDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CAMK2 alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50087267BDBM50087267((S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-ox...)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of human CaMKIIalpha using calmodulin and syntide-2 incubated for 15 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50217534BDBM50217534(CHEMBL413614)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory activity of compound against CaMKIIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2018
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163748BDBM50163748(4-(2-(5-(4-hydroxy-3-methoxystyryl)-1H-pyrazol-3-y...)
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50228744BDBM50228744(CHEBI:59612 | 5-Hydroxy-Diclofenac)
Affinity DataIC50: 1.81E+3nMAssay Description:Binding affinity to recombinant human CaMK2alpha 6x hub domain (345 to 475 residues) Trp403 residue assessed as inhibition of intrinsic tryptophan fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50128288BDBM50128288(3-(1-methyl-1H-indol-3-yl)-4-(1-(piperidin-4-yl)-1...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of purified mammalian brain [Ca(2+)]/Calmodulin dependent kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50128287BDBM50128287(3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-methyl-piperidi...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of purified mammalian brain [Ca(2+)]/Calmodulin dependent kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50563780BDBM50563780(CHEMBL4795714)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of wild-type human CAMK2alpha using KKALRRQETVDAL peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50128282BDBM50128282(3-(1H-Indol-3-yl)-4-[1-(1-methyl-piperidin-4-yl)-1...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of purified mammalian brain [Ca(2+)]/Calmodulin dependent kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50128281BDBM50128281(18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of purified mammalian brain [Ca(2+)]/Calmodulin dependent kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163748BDBM50163748(4-(2-(5-(4-hydroxy-3-methoxystyryl)-1H-pyrazol-3-y...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163748BDBM50163748(4-(2-(5-(4-hydroxy-3-methoxystyryl)-1H-pyrazol-3-y...)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of alphaCaMK2 autophosphorylation at Thr286 using [gamma32P]ATP incubated for 30 secs prior to ATP addition measured after 30 secsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50128280BDBM50128280(3-[1-(1-Ethyl-piperidin-4-yl)-1H-indol-3-yl]-4-(1-...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of purified mammalian brain [Ca(2+)]/Calmodulin dependent kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50128286BDBM50128286(3-[1-(1-Isopropyl-piperidin-4-yl)-1H-indol-3-yl]-4...)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of purified mammalian brain [Ca(2+)]/Calmodulin dependent kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50188913BDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CamK2alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50427874BDBM50427874(CHEMBL2324596)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human alphaCaMK2 by CaM kinase 2 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50235833BDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CAMK2A (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 236557BDBM236557(US9365572, 5)
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:Agents: 1-fold kinase buffer without MnCl2: 50 mM HEPES, pH 7.5, 0.0015% Brij-35, 10 mM MgCl2, 2 mM DTT. 1-fold kinase buffer with MnCl2: 50 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50133058BDBM50133058(17,20,23,26-tetraoxa-4,12,14,29,31-pentaazahexacyc...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Calcium/calmodulin-dependent protein kinase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50128285BDBM50128285(3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmet...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of purified mammalian brain [Ca(2+)]/Calmodulin dependent kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50133059BDBM50133059(Indolylylmaleimide 1 | 17,20,23-trioxa-4,12,14,26-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Calcium/calmodulin-dependent protein kinase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50133057BDBM50133057(17,20,23-trioxa-4,14,26-triazahexacyclo[24.6.1.17,...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Calcium/calmodulin-dependent protein kinase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50467836BDBM50467836(CHEMBL4282264)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CAMK2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503287BDBM50503287(ABT-494 | Rinvoq | Upadacitinib | US10961228, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CAMK2A (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50235820BDBM50235820(CHEMBL4066664)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CAMK2A (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50235830BDBM50235830(CHEMBL2006765)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CAMK2A (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
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