Compile Data Set for Download or QSAR
Report error Found 43 Enz. Inhib. hit(s) with BLAST sequence identity > 85%
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50235813(CHEMBL4097052)
Affinity DataIC50: 100nMAssay Description:Inhibition of alpha-hexosaminidase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM68271(M-31850)
Affinity DataIC50: 600nMT: 2°CAssay Description:Enzyme assay based on 4-MU substrates with HTS to identify inhibitory compounds for Hex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2011
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM18512(cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...)
Affinity DataIC50: 3.10E+3nMpH: 7.0Assay Description:Inhibition of human placental HexA using MUGS substrate incubated for 1 to 2 hrs at pH 7.0 by spectrofluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM68272(LU79953)
Affinity DataIC50: 4.60E+3nMT: 2°CAssay Description:Enzyme assay based on 4-MU substrates with HTS to identify inhibitory compounds for Hex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2011
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50491601(CHEMBL2333316)
Affinity DataIC50: 6.00E+3nMAssay Description:Competitive inhibition of human beta-N-acetyl-D-hexosaminidase-A using 4-Methylumbelliferyl N-acetyl-beta-D-glucosaminide as substrate assessed as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM18512(cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...)
Affinity DataIC50: 8.50E+3nMpH: 4.5Assay Description:Inhibition of HexA alpha G269S mutant in ATSD patient fibroblasts using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM18512(cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...)
Affinity DataIC50: 8.90E+3nMpH: 4.5Assay Description:Inhibition of human placental HexA using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM18788(CHEMBL22148 | 6-ethyl-5-phenylpyrimidine-2,4-diami...)
Affinity DataIC50: 1.10E+4nMpH: 7.0Assay Description:Inhibition of human placental HexA using MUGS substrate incubated for 1 to 2 hrs at pH 7.0 by spectrofluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM18512(cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...)
Affinity DataIC50: 1.40E+4nMpH: 4.5Assay Description:Inhibition of HexA in normal human fibroblasts using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50089680(CHEMBL3577321)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM68270(5141402)
Affinity DataIC50: 1.60E+4nMT: 2°CAssay Description:Enzyme assay based on 4-MU substrates with HTS to identify inhibitory compounds for Hex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2011
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM18512(cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50106194(BTB12933 | CHEMBL339586 | 1,3-dioxo-1H-benz[de]iso...)
Affinity DataIC50: 1.80E+4nMT: 2°CAssay Description:Enzyme assay based on 4-MU substrates with HTS to identify inhibitory compounds for Hex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2011
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50089676(CHEMBL3577317)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM18780(CHEMBL281412 | 6-ethyl-5-(4-methoxyphenyl)pyrimidi...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM18788(CHEMBL22148 | 6-ethyl-5-phenylpyrimidine-2,4-diami...)
Affinity DataIC50: 2.70E+4nMpH: 4.5Assay Description:Inhibition of HexA alpha G269S mutant in ATSD patient fibroblasts using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM18788(CHEMBL22148 | 6-ethyl-5-phenylpyrimidine-2,4-diami...)
Affinity DataIC50: 2.70E+4nMpH: 4.5Assay Description:Inhibition of HexA in normal human fibroblasts using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM18788(CHEMBL22148 | 6-ethyl-5-phenylpyrimidine-2,4-diami...)
Affinity DataIC50: 3.00E+4nMpH: 4.5Assay Description:Inhibition of human placental HexA using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM68269(M-31867)
Affinity DataIC50: 3.10E+4nMT: 2°CAssay Description:Enzyme assay based on 4-MU substrates with HTS to identify inhibitory compounds for Hex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2011
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM18788(CHEMBL22148 | 6-ethyl-5-phenylpyrimidine-2,4-diami...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50089681(CHEMBL3577322)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM18779(6-ethyl-5-(4-methylphenyl)pyrimidine-2,4-diamine |...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50089682(CHEMBL3577323)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50089683(CHEMBL3577324)
Affinity DataIC50: 4.70E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50190644(CHEMBL3983808)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of beta-hexosaminidase alpha in human skin fibroblast lysate using 4-MU-N-acetyl-beta-D-glucosaminide-6-sulfate sodium salt as substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2018
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50190645(CHEMBL3982827)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of beta-hexosaminidase alpha in human skin fibroblast lysate using 4-MU-N-acetyl-beta-D-glucosaminide-6-sulfate sodium salt as substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2018
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM68268(M-31862)
Affinity DataIC50: 1.08E+5nMT: 2°CAssay Description:Enzyme assay based on 4-MU substrates with HTS to identify inhibitory compounds for Hex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2011
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM68267(M-31860)
Affinity DataIC50: 1.38E+5nMT: 2°CAssay Description:Enzyme assay based on 4-MU substrates with HTS to identify inhibitory compounds for Hex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2011
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50235812(CHEMBL4085739)
Affinity DataIC50: 1.60E+5nMAssay Description:Inhibition of alpha-hexosaminidase in human PBMC using 4-methylumbelliferyl 2-acetamido-2-deoxy-alpha-D-glucopyranoside as substrate at pH 4.3 after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50089679(CHEMBL3577320)
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50190643(CHEMBL3933402)
Affinity DataIC50: 3.50E+5nMAssay Description:Inhibition of beta-hexosaminidase alpha in human skin fibroblast lysate using 4-MU-N-acetyl-beta-D-glucosaminide-6-sulfate sodium salt as substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2018
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50089674(CHEMBL3577315)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50089673(CHEMBL3577314)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50089677(CHEMBL3577318)
Affinity DataIC50: 4.10E+5nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM18775(CHEMBL21357 | 5-(4-chlorophenyl)-6-methylpyrimidin...)
Affinity DataIC50: 5.60E+5nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50089675(CHEMBL3577316)
Affinity DataIC50: 9.40E+5nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50089678(CHEMBL3577319)
Affinity DataIC50: 1.40E+6nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50089672(CHEMBL3577313)
Affinity DataIC50: 2.10E+6nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM40765(Iminocyclitol, 8)
Affinity DataKi:  100nMAssay Description:Hexosaminidase activity assay was measured by fluorometry, VersaFluor Fluorometer from Bio-Rad.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2011
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Bovine)
University of Debrecen

Curated by ChEMBL
LigandPNGBDBM50577836(CHEMBL4861823)
Affinity DataKi:  205nMAssay Description:Competitive inhibition of cow HexA/HexB (unknown origin) using pNP-GlcNAc as substrate assessed as inhibition constant by measuring liberation of nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50327038((3aR,5R,6S,7R,7aR)-5-(hydroxymethyl)-2-methyl-5,6,...)
Affinity DataKi:  270nMAssay Description:Competitive inhibition of human beta-N-acetyl-D-hexosaminidase-A using 4-Methylumbelliferyl N-acetyl-beta-D-glucosaminide as substrate assessed as re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM40767(Iminocyclitol, 10)
Affinity DataKi:  1.00E+4nMAssay Description:Hexosaminidase activity assay was measured by fluorometry, VersaFluor Fluorometer from Bio-Rad.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2011
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha Beta-hexosaminidase subunit alpha(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50394492(CHEMBL1765471)
Affinity DataKi:  1.63E+5nMAssay Description:Inhibition of human Hex A using 4-MU-GlcNAc as substrate after 10 mins by Lineweaver Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed