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TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207624(US9260440, 69 | US9617273, Example 69 | US10501467...)
Affinity DataEC50:  0.200nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataEC50:  0.400nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50549411(CHEMBL4776661)
Affinity DataEC50:  0.5nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207623(US9260440, 68 | US9617273, Example 68 | US10501467...)
Affinity DataEC50:  0.600nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50251661(2-(2-(pyrrolidin-1-yl)propan-2-yl)-1H-benzo[d]imid...)
Affinity DataEC50:  0.900nMAssay Description:Inhibition of PARP1 in cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50300018(2-(4-(Oxazol-5-yl)phenyl)-1H-benzo[d]imidazole-4-c...)
Affinity DataEC50:  0.990nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50315793(6-Fluoro-2-(4-piperidin-2-ylphenyl)-1H-benzimidazo...)
Affinity DataEC50:  1nMAssay Description:Inhibition of PARP1 in human C41 cells by FITC-conjugated DAPI stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50315792(6-Fluoro-2-(2-fluoro-4-pyrrolidin-2-ylphenyl)-1H-b...)
Affinity DataEC50:  1nMAssay Description:Inhibition of PARP1 in human C41 cells by FITC-conjugated DAPI stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50315779((S)-2-(2-Fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benz...)
Affinity DataEC50:  1nMAssay Description:Inhibition of PARP1 in human C41 cells by FITC-conjugated DAPI stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50387946(CHEMBL2058928 | US9283222, 536)
Affinity DataEC50:  1nMAssay Description:Inhibition of PARP1 in H202-stimulated human C41 cells incubated for 30 mins prior to H2O2-treatment measured after 10 mins by FITC-based immunostain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207601(US9260440, 46 | US9617273, Example 46 | US10501467...)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207604(US9260440, 49 | US9617273, Example 49 | US10501467...)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50251657(2-(2-(methylamino)propan-2-yl)-1H-benzo[d]imidazol...)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of PARP1 in cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207613(US9260440, 58 | US9617273, Example 58 | US10501467...)
Affinity DataEC50:  1.40nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50387944(CHEMBL2058926 | US9283222, 545)
Affinity DataEC50:  1.40nMAssay Description:Inhibition of PARP1 in H202-stimulated human C41 cells incubated for 30 mins prior to H2O2-treatment measured after 10 mins by FITC-based immunostain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50387942(CHEMBL2058923 | US9283222, 546)
Affinity DataEC50:  1.70nMAssay Description:Inhibition of PARP1 in H202-stimulated human C41 cells incubated for 30 mins prior to H2O2-treatment measured after 10 mins by FITC-based immunostain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207564(US9260440, 9 | US9617273, Example 9 | US10501467, ...)
Affinity DataEC50:  1.70nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50251658(2-(2-(dimethylamino)propan-2-yl)-1H-benzo[d]imidaz...)
Affinity DataEC50:  1.80nMAssay Description:Inhibition of PARP1 in cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207614(US9260440, 59 | US9617273, Example 59 | US10501467...)
Affinity DataEC50:  1.90nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50251620(2-(2-(isopropylamino)propan-2-yl)-1H-benzo[d]imida...)
Affinity DataEC50:  2nMAssay Description:Inhibition of PARP1 in cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50251621(2-(2-(cyclopropylmethylamino)propan-2-yl)-1H-benzo...)
Affinity DataEC50:  2nMAssay Description:Inhibition of PARP1 in cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50315795(6-Fluoro-2-(2-fluoro-4-piperidin-2-ylphenyl)-1H-be...)
Affinity DataEC50:  2nMAssay Description:Inhibition of PARP1 in human C41 cells by FITC-conjugated DAPI stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50315784(2-(4-(1-Methylpiperidin-2-yl)phenyl)-1H-benzimidaz...)
Affinity DataEC50:  2nMAssay Description:Inhibition of PARP1 in human C41 cells by FITC-conjugated DAPI stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM27135(2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazo...)
Affinity DataEC50:  2nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50315790(6-Fluoro-2-(4-pyrrolidin-2-ylphenyl)-1H-benzimidaz...)
Affinity DataEC50:  2nMAssay Description:Inhibition of PARP1 in human C41 cells by FITC-conjugated DAPI stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50300020(2-(4-(1H-Imidazol-2-yl)phenyl)-1H-benzo[d]imidazol...)
Affinity DataEC50:  2.20nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207596(US9260440, 41 | US9617273, Example 41 | US10501467...)
Affinity DataEC50:  2.30nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207566(US9260440, 11 | US9617273, Example 11 | US10501467...)
Affinity DataEC50:  2.40nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207595(US9260440, 40 | US9617273, Example 40 | US10501467...)
Affinity DataEC50:  2.40nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib | US12427157, Example R8H-15)
Affinity DataEC50:  2.5nMAssay Description:Inhibition of PARP in human LoVo cells assessed as inhibition of poly(ADP)-ribose polymerization for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataEC50:  2.5nMAssay Description:Inhibition of PARP-1 in human HeLa cells assessed as decrease of H2O2-induced PARylation after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207573(US9260440, 18 | US9617273, Example 18 | US10501467...)
Affinity DataEC50:  2.70nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207620(US9260440, 65 | US9617273, Example 65 | US10501467...)
Affinity DataEC50:  2.90nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207570(US9260440, 15 | US9617273, Example 15 | US10501467...)
Affinity DataEC50:  2.90nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50315780(2-(4-Pyrrolidin-2-ylphenyl)-1H-benzimidazole-4-car...)
Affinity DataEC50:  3nMAssay Description:Inhibition of PARP1 in human C41 cells by FITC-conjugated DAPI stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM27119(ABT472 | 2-(1-propylpiperidin-4-yl)-1H-1,3-benzodi...)
Affinity DataEC50:  3nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50499821(CHEMBL3740104)
Affinity DataEC50:  3nMAssay Description:Inhibition of PARP in human MDA-MB-468 cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50251619(2-(2-(propylamino)propan-2-yl)-1H-benzo[d]imidazol...)
Affinity DataEC50:  3nMAssay Description:Inhibition of PARP1 in cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50315797((R)-2-(2-Fluoro-4-piperidin-2-yl-phenyl)-1H-benzim...)
Affinity DataEC50:  3nMAssay Description:Inhibition of PARP1 in human C41 cells by FITC-conjugated DAPI stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207557(US9260440, 2 | US9617273, Example 2)
Affinity DataEC50:  3.10nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50251695(2-(2-(piperidin-1-yl)propan-2-yl)-1H-benzo[d]imida...)
Affinity DataEC50:  3.10nMAssay Description:Inhibition of PARP1 in cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib | US12427157, Example R8H-15)
Affinity DataEC50:  3.20nMAssay Description:Inhibition of human PARP-1 catalytic domain (662 to 1011 residues) expressed in Escherichia coli BL21(DE3) cells incubated for 0.5 hrs by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207586(US9260440, 31 | US9617273, Example 31 | US10501467...)
Affinity DataEC50:  3.20nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50387945(CHEMBL2058927 | US9283222, 511)
Affinity DataEC50:  3.30nMAssay Description:Inhibition of PARP1 in H202-stimulated human C41 cells incubated for 30 mins prior to H2O2-treatment measured after 10 mins by FITC-based immunostain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207612(US9260440, 57 | US9617273, Example 57 | US10501467...)
Affinity DataEC50:  3.40nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207563(US9260440, 8 | US9617273, Example 8 | US10501467, ...)
Affinity DataEC50:  3.5nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50549408(CHEMBL4784831)
Affinity DataEC50:  3.5nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataEC50:  3.60nMAssay Description:Inhibition of PARP in human LoVo cells assessed as inhibition of poly(ADP)-ribose polymerization for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM207556(US9260440, 1 | US9617273, Example 1 | US10501467, ...)
Affinity DataEC50:  3.60nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50300021(2-(4-(Thiazol-4-yl)phenyl)-1H-benzo[d]imidazole-4-...)
Affinity DataEC50:  3.70nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
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