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TargetBeta-galactosidase(Human)
Graz University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50254109BDBM50254109(CHEMBL4069909)
Affinity DataKi:  290nMAssay Description:Competitive inhibition of human fibroblast lysosomal beta-galactosidase using 4-methylumbelliferyl-beta-D-galactopyranoside as substrate pre-incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetBeta-galactosidase(Human)
Graz University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50358321BDBM50358321(CHEMBL1922579 | CHEMBL1922581)
Affinity DataKi:  300nMAssay Description:Inhibition of human beta galactosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-galactosidase(Human)
Graz University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182795BDBM50182795(5-(dimethylamino)-N-(6-((2R,3S,4R,5S)-3,4,5-trihyd...)
Affinity DataKi:  300nMAssay Description:Inhibition of human lysosomal beta-galactosidase assessed as inhibition of hydrolyzed 4-methylumbelliferone production after 30 mins by luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetBeta-galactosidase(Human)
Graz University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50358321BDBM50358321(CHEMBL1922579 | CHEMBL1922581)
Affinity DataKi:  510nMAssay Description:Competitive inhibition of human fibroblast lysosomal beta-galactosidase using 4-methylumbelliferyl-beta-D-galactopyranoside as substrate pre-incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-galactosidase(Human)
Graz University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246569BDBM50246569(Methyl 6-[N2-dansyl-N6-(1,5-dideoxy-D-galactitol-1...)
Affinity DataKi:  600nMAssay Description:Inhibition of human lysosomal beta-galactosidase assessed as inhibition of hydrolyzed 4-methylumbelliferone production after 30 mins by luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetBeta-galactosidase(Human)
Graz University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50356096BDBM50356096(CHEMBL1911831)
Affinity DataKi:  700nMAssay Description:Inhibition of human lysosomal beta-galactosidase assessed as inhibition of hydrolyzed 4-methylumbelliferone production after 30 mins by luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetBeta-galactosidase(Human)
Graz University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50356097BDBM50356097(CHEMBL461161)
Affinity DataKi:  700nMAssay Description:Inhibition of human lysosomal beta-galactosidase assessed as inhibition of hydrolyzed 4-methylumbelliferone production after 30 mins by luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetBeta-galactosidase [24-677,R201C](Human)
The University of Tokyo

LigandChemical structure of BindingDB Monomer ID 228800BDBM228800(NOEV | Sapienic acid (SpA))
Affinity DataKi:  940nM ΔG°:  -8.55kcal/molepH: 4.5 T: 2°CAssay Description:β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetBeta-galactosidase [24-677](Human)
The University of Tokyo

LigandChemical structure of BindingDB Monomer ID 228800BDBM228800(NOEV | Sapienic acid (SpA))
Affinity DataKi:  1.10E+3nM ΔG°:  -8.45kcal/molepH: 4.5 T: 2°CAssay Description:β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetBeta-galactosidase [24-677,I51T](Human)
The University of Tokyo

LigandChemical structure of BindingDB Monomer ID 228800BDBM228800(NOEV | Sapienic acid (SpA))
Affinity DataKi:  1.20E+3nM ΔG°:  -8.40kcal/molepH: 4.5 T: 2°CAssay Description:β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetBeta-galactosidase(Human)
Graz University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403936BDBM50403936(CHEMBL2114148)
Affinity DataKi:  6.40E+3nMAssay Description:Inhibition constant against Beta-galactosidase from Jack beans; Mixed (Non competitive and competitive)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-galactosidase(Human)
Graz University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403936BDBM50403936(CHEMBL2114148)
Affinity DataKi:  6.60E+3nMAssay Description:Inhibition constant against beta-Galactosidase from Aspergillus oryzae; Mixed (Non competitive and competitive)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-galactosidase(Human)
Graz University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50075942BDBM50075942(N-[2,5-Dihydroxy-6-hydroxymethyl-4-(3,4,5-trihydro...)
Affinity DataKi:  7.50E+3nMAssay Description:Inhibition constant against beta-galactosidase enzyme of jack bean was reportedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-galactosidase(Human)
Graz University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50254118BDBM50254118(CHEMBL4090899)
Affinity DataKi:  9.20E+3nMAssay Description:Competitive inhibition of human fibroblast lysosomal beta-galactosidase using 4-methylumbelliferyl-beta-D-galactopyranoside as substrate pre-incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetBeta-galactosidase(Human)
Graz University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403937BDBM50403937(CHEMBL2114149)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition constant against Beta-galactosidase from Aspergillus oryzae; Mixed (both competitive and non-competitive)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-galactosidase(Human)
Graz University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104296BDBM50104296(2-(2,2-Dihydroxy-ethyl)-pyrrolidine-3,4-diol | CHE...)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibitory activity towards Beta-galactosidase from Jack beanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetBeta-galactosidase [24-677,I51T](Human)
The University of Tokyo

LigandChemical structure of BindingDB Monomer ID 50163440BDBM50163440((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  4.47E+4nM ΔG°:  -6.17kcal/molepH: 4.5 T: 2°CAssay Description:β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-galactosidase [24-677,R201C](Human)
The University of Tokyo

LigandChemical structure of BindingDB Monomer ID 50163440BDBM50163440((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  4.90E+4nM ΔG°:  -6.11kcal/molepH: 4.5 T: 2°CAssay Description:β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-galactosidase [24-677,R201C](Human)
The University of Tokyo

LigandChemical structure of BindingDB Monomer ID 228802BDBM228802(5N,6S-(N'-butyliminomethylidene)-6-thio-1-deox...)
Affinity DataKi:  5.33E+4nM ΔG°:  -6.06kcal/molepH: 4.5 T: 2°CAssay Description:β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetBeta-galactosidase [24-677](Human)
The University of Tokyo

LigandChemical structure of BindingDB Monomer ID 50163440BDBM50163440((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  6.18E+4nM ΔG°:  -5.97kcal/molepH: 4.5 T: 2°CAssay Description:β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-galactosidase [24-677](Human)
The University of Tokyo

LigandChemical structure of BindingDB Monomer ID 228802BDBM228802(5N,6S-(N'-butyliminomethylidene)-6-thio-1-deox...)
Affinity DataKi:  6.83E+4nM ΔG°:  -5.91kcal/molepH: 4.5 T: 2°CAssay Description:β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetBeta-galactosidase [24-677,I51T](Human)
The University of Tokyo

LigandChemical structure of BindingDB Monomer ID 228802BDBM228802(5N,6S-(N'-butyliminomethylidene)-6-thio-1-deox...)
Affinity DataKi:  6.88E+4nM ΔG°:  -5.90kcal/molepH: 4.5 T: 2°CAssay Description:β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetBeta-galactosidase(Human)
Graz University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073992BDBM50073992(((3aS,4aS,7aS,7bR)-6,6-Dimethyl-3a,4a,7a,7b-tetrah...)
Affinity DataKi:  7.20E+4nMAssay Description:Inhibition of beta-galactosidase from Aspergillus oryzaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-galactosidase [24-677](Human)
The University of Tokyo

LigandChemical structure of BindingDB Monomer ID 228803BDBM228803(5N,6S-(N'-butyliminomethylidene)-6-thiogalacto...)
Affinity DataKi:  2.53E+5nM ΔG°:  -5.10kcal/molepH: 4.5 T: 2°CAssay Description:β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetBeta-galactosidase [24-677,I51T](Human)
The University of Tokyo

LigandChemical structure of BindingDB Monomer ID 228803BDBM228803(5N,6S-(N'-butyliminomethylidene)-6-thiogalacto...)
Affinity DataKi:  3.20E+5nM ΔG°:  -4.96kcal/molepH: 4.5 T: 2°CAssay Description:β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetBeta-galactosidase [24-677,R201C](Human)
The University of Tokyo

LigandChemical structure of BindingDB Monomer ID 228803BDBM228803(5N,6S-(N'-butyliminomethylidene)-6-thiogalacto...)
Affinity DataKi:  3.20E+5nM ΔG°:  -4.96kcal/molepH: 4.5 T: 2°CAssay Description:β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetBeta-galactosidase [24-677,I51T](Human)
The University of Tokyo

LigandChemical structure of BindingDB Monomer ID 228804BDBM228804(N-(N'-butylthiocarbamoyl)-1-deoxygalactonojiri...)
Affinity DataKi:  3.29E+5nM ΔG°:  -4.94kcal/molepH: 4.5 T: 2°CAssay Description:β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetBeta-galactosidase(Human)
Graz University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50298560BDBM50298560([1-(beta-D-Galactopyranosyl)-1H-1,2,3-triazol-4-yl...)
Affinity DataKi:  3.30E+5nMAssay Description:Inhibition of beta-galactosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetBeta-galactosidase [24-677](Human)
The University of Tokyo

LigandChemical structure of BindingDB Monomer ID 228804BDBM228804(N-(N'-butylthiocarbamoyl)-1-deoxygalactonojiri...)
Affinity DataKi:  3.73E+5nM ΔG°:  -4.86kcal/molepH: 4.5 T: 2°CAssay Description:β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetBeta-galactosidase [24-677,R201C](Human)
The University of Tokyo

LigandChemical structure of BindingDB Monomer ID 228804BDBM228804(N-(N'-butylthiocarbamoyl)-1-deoxygalactonojiri...)
Affinity DataKi:  3.88E+5nM ΔG°:  -4.84kcal/molepH: 4.5 T: 2°CAssay Description:β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetBeta-galactosidase [24-677](Human)
The University of Tokyo

LigandChemical structure of BindingDB Monomer ID 228805BDBM228805(Galactose)
Affinity DataKi:  4.14E+6nM ΔG°:  -3.38kcal/molepH: 4.5 T: 2°CAssay Description:β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetBeta-galactosidase [24-677,I51T](Human)
The University of Tokyo

LigandChemical structure of BindingDB Monomer ID 228805BDBM228805(Galactose)
Affinity DataKi:  4.91E+6nM ΔG°:  -3.27kcal/molepH: 4.5 T: 2°CAssay Description:β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed
TargetBeta-galactosidase [24-677,R201C](Human)
The University of Tokyo

LigandChemical structure of BindingDB Monomer ID 228805BDBM228805(Galactose)
Affinity DataKi:  5.61E+6nM ΔG°:  -3.19kcal/molepH: 4.5 T: 2°CAssay Description:β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2017
Entry Details Article
PubMed