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Found 78 of ic50 for UniProtKB: P00800
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50292712(1beta-D-arabinofuranosyl-N4-lauroylcytosine | CHEM...)
Affinity DataIC50:  0.0640nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50035249(CHEMBL303892 | N-[1-Carbamoyl-2-(1H-indol-3-yl)-et...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50105264(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50035247(2-(2-Hydroxycarbamoyl-3-methyl-butyrylamino)-3-(1H...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50035246(2-(2-Hydroxycarbamoyl-4-methyl-pentanoylamino)-3-(...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50044226(1-hydroxy-1-phenylethyl-phosphinoylamino]-propiony...)
Affinity DataIC50:  7nMAssay Description:Inhibition of metallopeptidase thermolysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50035239(CHEMBL63317 | N-[1-Carbamoyl-2-(1H-indol-3-yl)-eth...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50321113(3-Phenyl-2-(trifluoromethyl)quinazolin-4(3H)-one |...)
Affinity DataIC50:  11.5nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50251742((3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro...)
Affinity DataIC50:  33nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50035235(CHEMBL2372437 | N-[1-(Carbamoylmethyl-carbamoyl)-e...)
Affinity DataIC50:  64nMAssay Description:Compound was tested in vitro for inhibitory activity against thermolysinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056252((6S,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  68nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056252((6S,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  68nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50035235(CHEMBL2372437 | N-[1-(Carbamoylmethyl-carbamoyl)-e...)
Affinity DataIC50:  175nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50321123(3-(Isopropylideneamino)-2,2-dimethyl-2,3-dihydroqu...)
Affinity DataIC50:  248nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056249((6S,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50:  600nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056249((6S,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50:  600nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50321122(2-Ethylquinazolin-4(3H)-one | CHEMBL1163173)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056248((6R,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50024102(((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...)
Affinity DataIC50:  1.80E+3nMAssay Description:Tested for binding affinity against ThermolysinMore data for this Ligand-Target Pair
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056250((6S,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50035236(3-(2-Hydroxycarbamoyl-3-methyl-butyrylamino)-propi...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50035237(2-(2-Hydroxycarbamoylmethyl-3-methyl-butyrylamino)...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056247((6R,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056247((6R,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50038623(2-(2-Benzyl-3-mercapto-5-methyl-hexanoylamino)-pro...)
Affinity DataIC50:  4.00E+3nMAssay Description:Tested for binding affinity against ThermolysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056251((6R,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056251((6R,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50204382(2-(benzyloxyamino)-N-hydroxyhexanamide | CHEMBL228...)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 1 hr followed by the addition of 3.33 uM bradykinin like substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056258((3R,6S)-3-Mercaptomethyl-4-oxo-5-aza-bicyclo[10.3....)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056261((3R,6S)-3-Mercaptomethyl-4-oxo-5-aza-bicyclo[11.3....)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056256((6R,9S)-9-Mercaptomethyl-8-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056256((6R,9S)-9-Mercaptomethyl-8-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50138798(CHEMBL3754100)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 1 hr followed by the addition of 3.33 uM bradykinin like substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50138798(CHEMBL3754100)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 15 mins followed by the addition of 75 uM Abz-Ala-Gly-leu-Ala-p-n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50138801(CHEMBL3753984)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 15 mins followed by the addition of 75 uM Abz-Ala-Gly-leu-Ala-p-n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50138801(CHEMBL3753984)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 1 hr followed by the addition of 3.33 uM bradykinin like substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056259((3S,6S)-3-Mercaptomethyl-4-oxo-5-aza-bicyclo[11.3....)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50321112(3-Amino-2-(trifluoromethyl)quinazolin-4(3H)-one | ...)
Affinity DataIC50:  3.79E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056253((6S,9S)-9-Mercaptomethyl-8-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056253((6S,9S)-9-Mercaptomethyl-8-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056250((6S,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  4.10E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056248((6R,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  4.10E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50321118(3-({(1E)-[4-(Dimethylamino)phenyl]methylene}amino)...)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50274869(CHEMBL464808 | N-(2-chloro-6-methylphenyl)-2-hydro...)
Affinity DataIC50:  4.70E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056262((3S,6S)-3-Mercaptomethyl-4-oxo-5-aza-bicyclo[10.3....)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056254((6R,9S)-9-Mercaptomethyl-8-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50:  4.90E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056254((6R,9S)-9-Mercaptomethyl-8-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50:  4.90E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50321114(3-Amino-2-methylquinazolin-4(3H)-one | CHEMBL11631...)
Affinity DataIC50:  5.49E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Tromsø

Curated by ChEMBL
LigandPNGBDBM50056255((6R,9S)-9-Mercaptomethyl-8-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibitory concentration required to inhibit thermolysin (TLN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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