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TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50539801(CHEMBL4648912 | US11840533, Compound 70)
Affinity DataKd: <1nMAssay Description:Binding affinity to human partial length TRIM24 phd bromodomain (P790 to P977 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50539801(CHEMBL4648912 | US11840533, Compound 70)
Affinity DataKd: <1nMAssay Description:Binding affinity to human partial length TRIM24 (G862 to E980 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50150818(CHEMBL3774575)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to recombinant human TRIM24-PHD/bromodomain expressed in bacterial system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50150818(CHEMBL3774575)
Affinity DataKd:  31nMAssay Description:Binding affinity to recombinant human His-tagged TRIM24-PHD/bromodomain expressed in Escherichia coli strains BL21 (DE3) cells by isothermal titratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50148478(CHEMBL3769965 | US10702504, Compound A)
Affinity DataKd:  222nMAssay Description:Binding affinity to N-terminal His6-SUMO-1-tagged recombinant human TRIM24 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by iso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM220447(US9296741, 36 | US10633379, Compound X)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human TRIM24 (PHD, Bromo) (P790 to P977 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50607768(CHEMBL5219602)
Affinity DataKd:  1.26E+3nMAssay Description:Binding affinity to human TRIM24 bromodomain by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50453949(CHEMBL4208820 | US11247989, Example 87)
Affinity DataKd:  1.40E+3nMAssay Description:Binding affinity to human partial length TRIM24 (G862 to E980 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM179481(US9675697, Cpd. No. 73)
Affinity DataKd: >4.00E+3nMAssay Description:Binding affinity to human partial length TRIM24 expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50366670(CHEMBL4173488)
Affinity DataKd: >4.00E+3nMAssay Description:Binding affinity to human TRIM24 (P790 to P977 residues) expressed in bacterial expression system by BROMOScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM249277(US9458145, 1020-18 | US10017501, Compound 1020-18)
Affinity DataKd:  4.10E+3nMAssay Description:Binding affinity to TRIM24 bromodomain (unknown origin) after 1 hr by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50453949(CHEMBL4208820 | US11247989, Example 87)
Affinity DataKd:  5.40E+3nMAssay Description:Binding affinity to human partial length TRIM24 (P790 to P977 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM249277(US9458145, 1020-18 | US10017501, Compound 1020-18)
Affinity DataKd:  6.90E+3nMAssay Description:Binding affinity to human partial length TRIM24 (P790 to P977 residues) expressed in bacterial expression system after 1 hr by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50250892(CHEMBL4061254 | US10696655, Example 63 | US1116807...)
Affinity DataKd:  7.60E+3nMAssay Description:Binding affinity to human TRIM24 (G862 to E980) expressed in bacterial cells by BromoScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50504160(CHEMBL3133807 | US11773085, Compound B25)
Affinity DataKd:  8.48E+3nMAssay Description:Reverse ITC (compound as receptor). Domain start/stop: G861-E979More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50092310(US9675697, Cpd. No. 23 | CHEMBL3581661)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to biotinylated TRIM24 (790 to 972 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells by bio-layer interferometry...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length TRIM24 (P790 to P977 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50615275(CHEMBL5282240)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length TRIM24 (P790 to P977 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM321437((E)-6-(but-2-en-1-yl)-4-(4-(2-hydroxypropan-2-yl)-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length TRIM24 (P790 to P977 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50560174(GSK789)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to human partial length TRIM24 (P790 to P977 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50615276(CHEMBL5270178)
Affinity DataKd:  2.60E+4nMAssay Description:Binding affinity to human partial length TRIM24 (P790 to P977 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged TRIM24(PHD,Bromo.) expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468499(CHEMBL4291774)
Affinity DataKd: >5.00E+4nMAssay Description:Binding affinity to human partial length TRIM24-phd-bromo (P790 to P977 residues) expressed in Escherichia coli BL21 after 1 hr by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468549(CHEMBL4291772)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to human partial length TRIM24-phd-bromo (P790 to P977 residues) expressed in Escherichia coli BL21 after 1 hr by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468511(CHEMBL4293001)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to human partial length TRIM24-phd-bromo (P790 to P977 residues) expressed in Escherichia coli BL21 after 1 hr by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468501(CHEMBL4287943)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to human partial length TRIM24-phd-bromo (P790 to P977 residues) expressed in Escherichia coli BL21 after 1 hr by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed