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TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM771610(US12415819, Compound 58)
Affinity DataIC50: 0.0110nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/29/2025
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM771604(US12415819, Compound 52-B(OH)2)
Affinity DataIC50: 0.0150nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/29/2025
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50652827(CHEMBL5661917)
Affinity DataIC50: 0.0240nMAssay Description:Inhibition of human neutrophil elastase using MeOSuc-AAPV-MCA as substrate measured at 60 mins interval for up to several hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM771602(US12415819, Compound 51-B(OH)2)
Affinity DataIC50: 0.0300nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/29/2025
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50120437(CHEMBL3617973 | US12415819, Compound 54)
Affinity DataIC50: 0.0310nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2025
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50583309(CHEMBL4204851)
Affinity DataIC50: 0.0340nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50096484((4S,6R)-6-Allyl-4-(naphthalene-2-sulfonyl)-5-oxo-h...)
Affinity DataIC50: 0.0360nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50066997(CHEMBL2367632 | (3aS,6R)-6-Allyl-4-methanesulfonyl...)
Affinity DataIC50: 0.0470nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50120437(CHEMBL3617973 | US12415819, Compound 54)
Affinity DataIC50: 0.0650nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50120437(CHEMBL3617973 | US12415819, Compound 54)
Affinity DataIC50: 0.0650nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50120437(CHEMBL3617973 | US12415819, Compound 54)
Affinity DataIC50: 0.0650nMAssay Description:Inhibition of human neutrophil elastase using MeOSuc-AAPV-AMC as substrate measured after 60 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50120437(CHEMBL3617973 | US12415819, Compound 54)
Affinity DataIC50: 0.0650nMAssay Description:Inhibition of human neutrophil elastase using MeOSuc-AAPV-MCA as substrate measured at 60 mins interval for up to several hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM771607(POL6014 | US12415819, Compound 55)
Affinity DataIC50: 0.0930nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/29/2025
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50058495(3-{2-[2-(Thiophene-2-carbonylsulfanyl)-propionylam...)
Affinity DataIC50: 0.100nMAssay Description:Inhibitory concentration against Human Leukocyte Elastase from human sputumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50120428(CHEMBL3617966)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50556037(CHEMBL4744163)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human neutrophil elastase using MeOSuc-AAPV-AMC as substrate measured after 60 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50652828(CHEMBL5661855)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human neutrophil elastase using MeOSuc-AAPV-MCA as substrate measured at 60 mins interval for up to several hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50608626(CHEMBL5280380 | US12415819, Compound 50-B(OH)2)
Affinity DataIC50: 0.270nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2025
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50608626(CHEMBL5280380 | US12415819, Compound 50-B(OH)2)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM211514(US9290457, Example 1.56)
Affinity DataIC50: 0.300nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM104823(US8569314, 35)
Affinity DataIC50: 0.300nMAssay Description:In vitro HNE inhibition assay. The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amido...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2014
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM104822(US8569314, 23)
Affinity DataIC50: 0.300nMAssay Description:In vitro HNE inhibition assay. The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amido...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2014
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM104821(US8569314, 9)
Affinity DataIC50: 0.300nMAssay Description:In vitro HNE inhibition assay. The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amido...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2014
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM104820(US8569314, 5)
Affinity DataIC50: 0.300nMAssay Description:In vitro HNE inhibition assay. The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amido...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2014
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM104826(US8569314, 56)
Affinity DataIC50: 0.300nMAssay Description:In vitro HNE inhibition assay. The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amido...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2014
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM104825(US8569314, 53)
Affinity DataIC50: 0.300nMAssay Description:In vitro HNE inhibition assay. The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amido...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2014
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM104824(US8569314, 50)
Affinity DataIC50: 0.300nMAssay Description:In vitro HNE inhibition assay. The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amido...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2014
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189812(US9174997, 10)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189814(US9174997, 14)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189813(US9174997, 12)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50120436(CHEMBL3617972)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human neutrophil elastase using MeOSuc-AAPV-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189820(US9174997, 33)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189819(US9174997, 32)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189822(US9174997, 41)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189821(US9174997, 36)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189815(US9174997, 18)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189818(US9174997, 27)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189860(US9174997, 80)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189871(US9174997, 91)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189865(US9174997, 85)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189823(US9174997, 43 (Diastereomer 1))
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189835(US9174997, 55)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189831(US9174997, 51)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189908(US9174997, 128)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189924(US9174997, 144)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189921(US9174997, 141)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189883(US9174997, 103)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189876(US9174997, 96)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189900(US9174997, 120)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetNeutrophil elastase(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM189896(US9174997, 116)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

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