Compile Data Set for Download or QSAR
Report error Found 29 of ec50 data for polymerid = 5137
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50363325BDBM50363325(CHEMBL1945843)
Affinity DataEC50:  1.10nMAssay Description:Antagonist activity at human recombinant 5HT3 receptor assessed as inhibition of RAMH-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334438BDBM50334438((R)-7-oxo-N-(quinuclidin-3-yl)-4,7-dihydrothieno[3...)
Affinity DataEC50:  5.40nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as effect on serotonin-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334439BDBM50334439(CHEMBL1643883 | US8501729, 12 | (R)-2-methyl-7-(qu...)
Affinity DataEC50:  6.90nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as decrease in 10 uM 5-chloroindole-induced increase in intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334438BDBM50334438((R)-7-oxo-N-(quinuclidin-3-yl)-4,7-dihydrothieno[3...)
Affinity DataEC50:  9.20nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as decrease in 10 uM 5-chloroindole-induced increase in intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334439BDBM50334439(CHEMBL1643883 | US8501729, 12 | (R)-2-methyl-7-(qu...)
Affinity DataEC50:  12.6nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as effect on serotonin-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334440BDBM50334440(US8501729, 16 | CHEMBL1643881 | (R)-7-(quinuclidin...)
Affinity DataEC50:  14.5nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as effect on serotonin-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 36022BDBM36022(Octopamine,(+/-) | (+/-)-octopamine)
Affinity DataEC50:  24nMAssay Description:Activity at SER3 receptor expressed in HEK293 cells assessed as increase in calcium by calcium imaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10755BDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | CHEMBL535832 | ...)
Affinity DataEC50:  141nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as decrease in 10 uM 5-chloroindole-induced increase in intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10755BDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | CHEMBL535832 | ...)
Affinity DataEC50:  178nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as effect on serotonin-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014556BDBM50014556(CHEMBL3261486 | US9045501, 25)
Affinity DataEC50:  178nMAssay Description:Agonist activity at human 5-HT3A receptor expressed in HEK293 cells in presence of carbacholMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014550BDBM50014550(CHEMBL3261481 | US9045501, 7)
Affinity DataEC50:  178nMAssay Description:Agonist activity at human 5-HT3A receptor expressed in HEK293 cells in presence of carbacholMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014551BDBM50014551(CHEMBL3261482)
Affinity DataEC50:  178nMAssay Description:Agonist activity at human 5-HT3A receptor expressed in HEK293 cells in presence of carbacholMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014552BDBM50014552(CHEMBL3261483 | US9045501, 8)
Affinity DataEC50:  178nMAssay Description:Agonist activity at human 5-HT3A receptor expressed in HEK293 cells in presence of carbacholMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014554BDBM50014554(CHEMBL3261485)
Affinity DataEC50:  178nMAssay Description:Agonist activity at human 5-HT3A receptor expressed in HEK293 cells in presence of carbacholMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014548BDBM50014548(CHEMBL3261479 | US9045501, 2)
Affinity DataEC50:  178nMAssay Description:Agonist activity at human 5-HT3A receptor expressed in HEK293 cells in presence of carbacholMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50103074BDBM50103074(1-Allyl-2-piperazin-1-yl-1H-benzoimidazole | CHEMB...)
Affinity DataEC50:  240nMAssay Description:Binding affinity against human 5-hydroxytryptamine 3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443668BDBM50443668(CHEBI:5537 | CHEMBL1290003 | GRANISETRON)
Affinity DataEC50:  320nMAssay Description:Agonist activity at human wild type 5-HT3A receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10755BDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | CHEMBL535832 | ...)
Affinity DataEC50:  457nMAssay Description:Antagonist activity at human 5HT3A receptor expressed in HEK293 cells by FMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50400902BDBM50400902(CHEMBL2204360 | vortioxetine hydrobromide | 1-(2-(...)
Affinity DataEC50:  2.10E+3nMAssay Description:Agonist activity at human 5HT3A receptor expressed in xenopus oocytes by electrophysiological methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301927BDBM50301927(Norcisapride | CHEMBL1748)
Affinity DataEC50:  2.30E+3nMAssay Description:Antagonist activity at human recombinant 5-HT3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50053615BDBM50053615(m-chlorophenylbiguanidine | 3-Chloro-Phenyl biguan...)
Affinity DataEC50:  3.80E+3nMAssay Description:Agonist activity at human 5-HT43A receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301929BDBM50301929(4-amino-5-chloro-N-((3S,4R)-1-(((1S,2S)-2-hydroxy-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Antagonist activity at human recombinant 5-HT3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50516235BDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]BRL43694 from recombinant human 5HT3 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229715BDBM50229715(CHEMBL4070615)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at 5-HT3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50464234BDBM50464234(CHEMBL4284872)
Affinity DataEC50: >2.50E+4nMAssay Description:Potentiation of human 5-HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238419BDBM50238419(CHEMBL4060134)
Affinity DataEC50:  2.51E+4nMAssay Description:Inhibition of human serotonin receptor 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 29135BDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataEC50:  2.60E+4nMAssay Description:Activity at SER3 receptor expressed in HEK293 cells assessed as increase in calcium by calcium imaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044849BDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity at human 5-HT3 receptor by FLIPR(Abse5) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Cephalon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044849BDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity at human 5-HT3 receptor by FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed