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TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50506948(CHEMBL4448806)
Affinity DataIC50: 1nMAssay Description:Inhibition of PKG1A (unknown origin) incubated for 2 hrs by AbbVie kinase panel assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human PKG1alpha using LRRASLG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human PKG1alpha using LRRASLG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human PKG1a using LRRASLG as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by rad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human PKG1beta using LRRASLG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human PKG1beta using LRRASLG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human PKG1b using LRRASLG as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by rad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 5nMAssay Description:Inhibition of PRKG1 (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2017
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50630232(CHEMBL5433617)
Affinity DataIC50: 11nMAssay Description:Inhibition of PKG1 alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50630232(CHEMBL5433617)
Affinity DataIC50: 15nMAssay Description:Inhibition of PKG1 beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50506921(CHEMBL4459800)
Affinity DataIC50: 17nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 34nMAssay Description:Inhibition of human PRKG1 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50597473(CHEMBL5181094)
Affinity DataIC50: 39nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM27249(N-[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidami...)
Affinity DataIC50: 42nMAssay Description:Displacement of fluorescent-ARC-583/ARC-1042/ARC-1059 from His6-tagged recombinant human PKG1alpha by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50398379(CHEMBL2177390 | US10550114, Compound GDC-0068 | US...)
Affinity DataIC50: 69nMAssay Description:Inhibition of PRKG1betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50398379(CHEMBL2177390 | US10550114, Compound GDC-0068 | US...)
Affinity DataIC50: 98nMAssay Description:Inhibition of PRKG1alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50597471(CHEMBL5176687)
Affinity DataIC50: 320nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50: 517nMAssay Description:Inhibition of recombinant full length human PKG1alpha using RRRLSFAEPG as substrate incubated for 40 mins in presence of [gamma-33P]ATP and 10 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50: 660nMAssay Description:Inhibition of recombinant full length human PKG1beta using RRRLSFAEPG as substrate incubated for 40 mins in presence of [gamma-33P]ATP by radiometric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human wild type PKG1 alpha using 3xChocktide-PKC(19to 31) as substrate preincubated for 2 hrs followed by ATP addition and measured eve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PRKG1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50525788(CHEMBL4474940)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length PKG1alpha expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50182362(4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)imi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length PKG1beta expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50525788(CHEMBL4474940)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length PKG1beta expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50182362(4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)imi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length PKG1alpha expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM174948(US9096593, P-2049)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PRKG1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PRKG1 using LRRASLG as substrate in presence of [gamma33P]-ATP by HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50597489(CHEMBL5208605)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50597485(CHEMBL5183751)
Affinity DataIC50: 1.83E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50382218(CHEMBL2023842)
Affinity DataIC50: 1.86E+3nMAssay Description:Displacement of fluorescent-ARC-583/ARC-1042/ARC-1059 from His6-tagged recombinant human PKG1alpha by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50597496(CHEMBL5206259)
Affinity DataIC50: 2.25E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50597490(CHEMBL5199904)
Affinity DataIC50: 2.34E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50308898(3-[3-(4-Amido-phenyl)-ureidomethyl]-N-(1,2,3,4-tet...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of PRKG1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 3.37E+3nMAssay Description:Inhibition of human PRKG1 in presence of ATP by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50597472(CHEMBL5186844)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50597479(CHEMBL5184099)
Affinity DataIC50: 5.03E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50308876(3,4-Dimethoxy-N-[3-(1,2,3,4-tetrahydro-isoquinolin...)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of PRKG1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50597493(CHEMBL5192610)
Affinity DataIC50: 6.65E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50597492(CHEMBL5186165)
Affinity DataIC50: 8.14E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50503287(ABT-494 | Rinvoq | Upadacitinib | US10961228, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKG1A (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50429867(CHEMBL2333365)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKG1beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50467836(CHEMBL4282264)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKG1alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235816(CHEMBL4069365)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKG1A (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50135286(CHEMBL3745885)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PKG1beta using [LRRASLG] as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKG1A (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50135286(CHEMBL3745885)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PKG1alpha using [LRRASLG] as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50597488(CHEMBL5180112)
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50597487(CHEMBL5169406)
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50597494(CHEMBL5188032)
Affinity DataIC50: 1.89E+4nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50597478(CHEMBL5209364)
Affinity DataIC50: 1.94E+4nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
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