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TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50007522(CHEMBL289330 | 5-Bromo-N-(1-ethyl-pyrrolidin-2-ylm...)
Affinity DataKi:  0.00300nMAssay Description:Binding affinity to dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50008782(CHEMBL44237 | EPIDEPRIDE | Epidepride;N-(1-Ethyl-p...)
Affinity DataKi:  0.0100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50005120(Nemonapride | N-((2S,3S)-1-Benzyl-2-methyl-pyrroli...)
Affinity DataKi:  0.0100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50220541(N-(((S)-1-allylpyrrolidin-2-yl)methyl)-5-(3-fluoro...)
Affinity DataKi:  0.0200nMAssay Description:Binding affinity to D2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM81492(CAS_2062-84-2 | NSC_16363 | BENPERIDOL)
Affinity DataKi:  0.0270nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50183266(Anquil | Benperidol | Benquil | MCN-JR-4584 | R-45...)
Affinity DataKi:  0.0270nMAssay Description:Binding affinity to human dopamine D2 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2017
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.0300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.0300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM86187(CAS_22189-31-7 | NSC_5454 | THIOTHIXENE)
Affinity DataKi:  0.0300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50008782(CHEMBL44237 | EPIDEPRIDE | Epidepride;N-(1-Ethyl-p...)
Affinity DataKi:  0.0300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.0300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50074092(6'-oxo-1-[(2S)-tetrahydro-1H-2-pyrrolylcarbonyl]-(...)
Affinity DataKi:  0.0310nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50060601(L-pro-L-leu-gly-NH2 | L-prolyl-L-leucylglycinamide...)
Affinity DataKi:  0.0400nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50005120(Nemonapride | N-((2S,3S)-1-Benzyl-2-methyl-pyrroli...)
Affinity DataKi:  0.0400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50241119(CHEMBL218166 | 7-(4-Biphenyl-3-ylmethyl-piperazin-...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor at high affinity state expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50008735(CHEMBL8514 | BUTACLAMOL,d- | (+)-3-(tert-butyl)-(3...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]methylspiperone from human D2S receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50008735(CHEMBL8514 | BUTACLAMOL,d- | (+)-3-(tert-butyl)-(3...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]methylspiperone from human recombinant D2S receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50074093(RHPS4 | (2R,3'S,8a'R)-5'-oxo-1-((S)-pyrrolidine-2-...)
Affinity DataKi:  0.0500nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.0500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.0500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50008735(CHEMBL8514 | BUTACLAMOL,d- | (+)-3-(tert-butyl)-(3...)
Affinity DataKi:  0.0500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50530705(CHEMBL4451384)
Affinity DataKi:  0.0525nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50530705(CHEMBL4451384)
Affinity DataKi:  0.0525nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.0530nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50327606(6-(4-(4-(2,3-dihydro-1H-inden-4-yl)piperazin-1-yl)...)
Affinity DataKi:  0.0575nMAssay Description:Displacement of [3H]-Spiperone from human dopamine D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50123626(CHEMBL1303 | Neupro | (S)-6-[Propyl-(2-thiophen-2-...)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity was evaluated by calculating competition for [3H]N-0437 binding on Dopamine receptor D2L of CHO K-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [125I]ABN from human dopamine D2 long receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2019
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [125I]IABN from recombinant human D2 long receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.0600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50008782(CHEMBL44237 | EPIDEPRIDE | Epidepride;N-(1-Ethyl-p...)
Affinity DataKi:  0.0600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50123626(CHEMBL1303 | Neupro | (S)-6-[Propyl-(2-thiophen-2-...)
Affinity DataKi:  0.0600nMAssay Description:In vitro binding affinity at human Dopamine receptor D2 expressed in CHO K1 cells was measured by its ability to displace [3H]- N-0437More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.0600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50060601(L-pro-L-leu-gly-NH2 | L-prolyl-L-leucylglycinamide...)
Affinity DataKi:  0.0600nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity against dopamine receptor D2 by using [3H]spiperone as radioligand in caudate-putamen of monkeyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50074092(6'-oxo-1-[(2S)-tetrahydro-1H-2-pyrrolylcarbonyl]-(...)
Affinity DataKi:  0.0640nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50074093(RHPS4 | (2R,3'S,8a'R)-5'-oxo-1-((S)-pyrrolidine-2-...)
Affinity DataKi:  0.0670nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM179867(US9132134, Metopimazine (NG101) | US11147820, Comp...)
Affinity DataKi:  0.0700nMAssay Description:The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50349871(CHEMBL1813595)
Affinity DataKi:  0.0700nMAssay Description:Displacement of [125I]ABN from human recombinant D2L receptor expressed in HEK cells after 60 mins by gamma counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM179867(US9132134, Metopimazine (NG101) | US11147820, Comp...)
Affinity DataKi:  0.0700nMAssay Description:For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.0700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.0700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50074092(6'-oxo-1-[(2S)-tetrahydro-1H-2-pyrrolylcarbonyl]-(...)
Affinity DataKi:  0.0710nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50007422((R)-10,11-Dihydroxy-6-propyl-5,6,6a,7-tetrahydro-4...)
Affinity DataKi:  0.0741nMAssay Description:Displacement of [3H]spiperone from high-affinity state of human dopamine D2L receptor transfected in HEK293 cells after 2 hrs by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50007422((R)-10,11-Dihydroxy-6-propyl-5,6,6a,7-tetrahydro-4...)
Affinity DataKi:  0.0750nMAssay Description:Displacement of [3H]spiperone from high-affinity state of human dopamine D2L receptor transfected in HEK293 cells after 2 hrs by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50005120(Nemonapride | N-((2S,3S)-1-Benzyl-2-methyl-pyrroli...)
Affinity DataKi:  0.0800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.0800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50007518(3-Chloro-5-ethyl-N-((S)-1-ethyl-pyrrolidin-2-ylmet...)
Affinity DataKi:  0.0860nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.0890nMAssay Description:Displacement of [3H]Spiperone from human recombinant dopamine D2S receptor expressed in CHO cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50005120(Nemonapride | N-((2S,3S)-1-Benzyl-2-methyl-pyrroli...)
Affinity DataKi:  0.0900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institutet

Curated by ChEMBL
LigandPNGBDBM50074093(RHPS4 | (2R,3'S,8a'R)-5'-oxo-1-((S)-pyrrolidine-2-...)
Affinity DataKi:  0.0900nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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