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Found 3246 of ic50 for UniProtKB: P05979
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  0.0100nMAssay Description:COX activity was measured using a commercial kit (COX Inhibitor Screening Assay Kit Cayman Chemical N. 560131) which includes both ovine COX-1 and hu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153360(CHEMBL3774784)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of ovine COX1 assessed as production of PGF2-alpha preincubated with compound followed by the addition of 5 uM arachidonic acid as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate incubated for 5 mins by colorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50219329(CHEMBL8968)
Affinity DataIC50: <1nMAssay Description:Inhibitory activity (RA1) against Prostaglandin G/H synthase 1 was calculated relative to aspirinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50088679(2-Phenyl-isoindole-1,3-dione | 2-phenyl-1H-isoindo...)
Affinity DataIC50: <1nMAssay Description:Inhibitory activity (RA1) against Prostaglandin G/H synthase 1 was calculated relative to aspirinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50066441(2-(2,6-Dimethyl-phenyl)-isoindole-1,3-dione | 2-(2...)
Affinity DataIC50: <1nMAssay Description:Inhibitory activity (RA1) against Prostaglandin G/H synthase 1 was calculated relative to aspirinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50269235(12-O-[(2R)-N,N-dimethyl-3-methylbutanoyl]phorbol 1...)
Affinity DataIC50:  1nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50269230(12-O-[(2R)-N,N-dimethyl-3-methylbutanoyl]-4-deoxyp...)
Affinity DataIC50:  1nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50269236(3 beta-O-acetyloleanolic acid | CHEMBL503071)
Affinity DataIC50:  1nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50376383(CHEMBL259972)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of ovine COX-1 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50189988(CHEMBL214101 | Rofecoxib analogue)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50325646(1-(4-Methoxyphenyl)-3-trifluoromethyl-5-(3-methyl-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of sheep COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50189989(4-(4-methylphenyl)-1-[4-(5-tetrazolyl)phenyl]-3-(t...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50044262(CHEMBL3314084)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of ovine COX-1 assessed as decrease in prostaglandin production using arachidonic acid as substrate incubated with enzyme for 10 mins prio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM13065(5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluor...)
Affinity DataIC50:  6nMAssay Description:Inhibition of ovine COX-1 assessed as reduction in PGE2 production using 10 uM arachidonic acid as substrate preincubated with enzyme for 5 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  6nMAssay Description:Inhibition of ovine COX1 after 5 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  6nMAssay Description:Inhibition of ovine COX-1 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 1 min prior to substrate addition measured for 25 secs by TMPD-based chrom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM13065(5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluor...)
Affinity DataIC50:  7nMAssay Description:Inhibition of ovine COX-1 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50376383(CHEMBL259972)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of ovine COX1 catalytic activity using arachidonic acid as substrate preincubated for 5 mins followed by substrate and hemin addition meas...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50376383(CHEMBL259972)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of ovine COX1 using arachidonic acid as substrate by colorimetric assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50556691(CHEMBL4760140)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of ovine COX-1 assessed as peroxidase activity using arachidonic acid as substrate by colorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50038399(CHEMBL3361124)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate incubated for 5 mins by colorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM13065(5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluor...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of ovine COX1 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50038394(CHEMBL3361119)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate incubated for 5 mins by colorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153352(CHEMBL3774941)
Affinity DataIC50:  9nMAssay Description:Inhibition of ovine COX1 assessed as production of PGF2-alpha preincubated with compound followed by the addition of 5 uM arachidonic acid as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50038401(CHEMBL3361126)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate incubated for 5 mins by colorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM13065(5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluor...)
Affinity DataIC50:  10nMAssay Description:Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153354(CHEMBL3775510)
Affinity DataIC50:  10nMAssay Description:Inhibition of ovine COX1 assessed as production of PGF2-alpha preincubated with compound followed by the addition of 5 uM arachidonic acid as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50326129(Indometacin)
Affinity DataIC50:  10nMAssay Description:Inhibition of ovine COX1 by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM24566(2-({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidi...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50006805(3-(1-(4-chlorobenzyl)-3-(tert-butylthio)-5-isoprop...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM22334(BW A4C | BW4C | BWA4C | BWA4C, 10 | CHEMBL314360 |...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50273442(2-(4-Chloro-6-(5-methoxy-2-methylbiphenyl-4-ylamin...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50273441((R)-2-(4-Chloro-6-(4'-cyanobiphenyl-4-ylamino)pyri...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50273390((S)-2-(4-Chloro-6-(4'-cyanobiphenyl-4-ylamino)pyri...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50273389(2-(4-Chloro-6-(4'-cyanobiphenyl-4-ylamino)pyrimidi...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50273388(CHEMBL456575 | Ethyl 2-(4-(biphenyl-4-ylmethylamin...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50273710(2-(4-(Biphenyl-4-ylmethylamino)-6-chloropyrimidin-...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50273709(2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidine-2-ylt...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50273708(CHEMBL460615 | Ethyl 2-(4-chloro-6-(2-phenoxyethyl...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50273707(2-(4-Chloro-6-(2-phenoxyethylamino)pyrimidin-2-ylt...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50273685(2-(4-Chloro-6-(phenethylamino)pyrimidin-2-ylthio)o...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50273684(CHEMBL460184 | Ethyl 2-(4,6-diphenethoxypyrimidin-...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50273683(2-(4,6-Diphenethoxypyrimidin-2-ylthio)hexanoic aci...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50273682(2-(4,6-Diphenethoxypyrimidin-2-ylthio)acetic acid ...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM24565(2-({4-chloro-6-[(quinolin-6-ylmethyl)amino]pyrimid...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50253880(2-(4-chloro-6-(quinolin-6-yloxy)pyrimidin-2-ylthio...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM24561(CHEMBL459722 | Pirinixic acid-based compound, 6d |...)
Affinity DataIC50: >10nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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