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Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM198005(US9221790, 15)
Affinity DataIC50: 0.00200nMAssay Description:The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM197995(US9221790, 5)
Affinity DataIC50: 0.00500nMAssay Description:The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM197993(US9221790, 3)
Affinity DataIC50: 0.0390nMAssay Description:The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM197997(US9221790, 7)
Affinity DataIC50: 0.0670nMAssay Description:The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM198000(US9221790, 10)
Affinity DataIC50: 0.0760nMAssay Description:The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM197996(US9221790, 6)
Affinity DataIC50: 0.103nMAssay Description:The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM198003(US9221790, 13)
Affinity DataIC50: 0.134nMAssay Description:The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM197992(US9221790, 2)
Affinity DataIC50: 0.164nMAssay Description:The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM197998(US9221790, 8)
Affinity DataIC50: 0.182nMAssay Description:The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM29525(GR 113808 | [3H] GR 113808 | CHEMBL518682 | 3H-GR1...)
Affinity DataIC50: 0.210nMAssay Description:Antagonist activity at human 5HT4ER expressed in CHO cells assessed as reduction in cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM197991(US9221790, 1)
Affinity DataIC50: 0.226nMAssay Description:The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM197994(US9221790, 4)
Affinity DataIC50: 0.229nMAssay Description:The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM197999(US9221790, 9)
Affinity DataIC50: 0.267nMAssay Description:The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 0.362nMAssay Description:The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM198004(US9221790, 14)
Affinity DataIC50: 0.375nMAssay Description:The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM198002(US9221790, 12)
Affinity DataIC50: 0.421nMAssay Description:The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM198001(US9221790, 11)
Affinity DataIC50: 0.454nMAssay Description:The binding affinity of the compounds for a human 5-HT4 receptor was assayed according to the method as disclosed in the literature [Wyngaert et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM85026(SB-207266 | N-(1-Butylpiperidine-4-ylmethyl)-1,2-(...)
Affinity DataIC50: 0.630nMAssay Description:Binding affinity was determined against 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50398963(CHEMBL2179674)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at human 5HT4ER expressed in CHO cells assessed as reduction in cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50515598(CHEMBL4526049)
Affinity DataIC50: 7.5nMAssay Description:Displacement of [3H]-GR 113808 from recombinant human brain 5HT4 receptor measured after 60 mins by radio ligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50398964(CHEMBL2179707)
Affinity DataIC50: 9.80nMAssay Description:Antagonist activity at human 5HT4ER expressed in CHO cells assessed as reduction in cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50530423(CHEMBL4451349)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at 5-HT4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50530423(CHEMBL4451349)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at 5-HT4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50515600(CHEMBL4580044)
Affinity DataIC50: 15nMAssay Description:Displacement of [3H]-GR 113808 from recombinant human brain 5HT4 receptor measured after 60 mins by radio ligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50301927(Norcisapride | CHEMBL1748)
Affinity DataIC50: 19nMAssay Description:Displacement of [3H]GR-113808 from human recombinant 5-HT4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50056415(CHEMBL83954 | RS 23597 | 4-Amino-5-chloro-2-methox...)
Affinity DataIC50: 49nMAssay Description:Partial agonist activity at Rluc-tagged human 5HT4R expressed in human SH-SY5Y cells assessed as effect on serotonin-induced receptor/Gbeta1 coupling...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50142926(CHEMBL3759759)
Affinity DataIC50: 52nMAssay Description:Displacement of [3H]-GR113808 from human 5-HT4 receptor expressed in African green monkey COS7 cell membranes after 30 mins by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50142909(CHEMBL3759928)
Affinity DataIC50: 66nMAssay Description:Displacement of [3H]-GR113808 from human 5-HT4 receptor expressed in African green monkey COS7 cell membranes after 30 mins by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50142929(CHEMBL3758309)
Affinity DataIC50: 68nMAssay Description:Displacement of [3H]-GR113808 from human 5-HT4 receptor expressed in African green monkey COS7 cell membranes after 30 mins by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50142928(CHEMBL3758976)
Affinity DataIC50: 73nMAssay Description:Displacement of [3H]-GR113808 from human 5-HT4 receptor expressed in African green monkey COS7 cell membranes after 30 mins by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50142921(CHEMBL3758433)
Affinity DataIC50: 78nMAssay Description:Displacement of [3H]-GR113808 from human 5-HT4 receptor expressed in African green monkey COS7 cell membranes after 30 mins by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50515599(CHEMBL4457426)
Affinity DataIC50: 101nMAssay Description:Displacement of [3H]-GR 113808 from recombinant human brain 5HT4 receptor measured after 60 mins by radio ligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50019523(CHEMBL3291078)
Affinity DataIC50: 110nMAssay Description:Antagonist activity at Rluc-tagged human 5HT4R expressed in human SH-SY5Y cells assessed as inhibition of serotonin-induced receptor/Gbeta1 coupling ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50142920(CHEMBL3759944)
Affinity DataIC50: 118nMAssay Description:Displacement of [3H]-GR113808 from human 5-HT4 receptor expressed in African green monkey COS7 cell membranes after 30 mins by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50142919(CHEMBL3759860)
Affinity DataIC50: 134nMAssay Description:Displacement of [3H]-GR113808 from human 5-HT4 receptor expressed in African green monkey COS7 cell membranes after 30 mins by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50142923(CHEMBL3758641)
Affinity DataIC50: 134nMAssay Description:Displacement of [3H]-GR113808 from human 5-HT4 receptor expressed in African green monkey COS7 cell membranes after 30 mins by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50142925(CHEMBL3758674)
Affinity DataIC50: 155nMAssay Description:Displacement of [3H]-GR113808 from human 5-HT4 receptor expressed in African green monkey COS7 cell membranes after 30 mins by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50142918(CHEMBL3759546)
Affinity DataIC50: 178nMAssay Description:Displacement of [3H]-GR113808 from human 5-HT4 receptor expressed in African green monkey COS7 cell membranes after 30 mins by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50142904(CHEMBL3759969)
Affinity DataIC50: 190nMAssay Description:Displacement of [3H]-GR113808 from human 5-HT4 receptor expressed in African green monkey COS7 cell membranes after 30 mins by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50019524(CHEMBL3291079)
Affinity DataIC50: 195nMAssay Description:Partial agonist activity at Rluc-tagged human 5HT4R expressed in human SH-SY5Y cells assessed as effect on serotonin-induced receptor/Gbeta1 coupling...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50019520(CHEMBL3291075)
Affinity DataIC50: 203nMAssay Description:Antagonist activity at Rluc-tagged human 5HT4R expressed in human SH-SY5Y cells assessed as inhibition of serotonin-induced receptor/Gbeta1 coupling ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataIC50: 323nMAssay Description:Displacement of [3H]-GR 113808 from recombinant human brain 5HT4 receptor measured after 60 mins by radio ligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50142907(CHEMBL3759259)
Affinity DataIC50: 329nMAssay Description:Displacement of [3H]-GR113808 from human 5-HT4 receptor expressed in African green monkey COS7 cell membranes after 30 mins by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50142922(CHEMBL3758398)
Affinity DataIC50: 377nMAssay Description:Displacement of [3H]-GR113808 from human 5-HT4 receptor expressed in African green monkey COS7 cell membranes after 30 mins by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50019525(CHEMBL3291080)
Affinity DataIC50: 453nMAssay Description:Antagonist activity at Rluc-tagged human 5HT4R expressed in human SH-SY5Y cells assessed as inhibition of serotonin-induced receptor/Gbeta1 coupling ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50: 483nMAssay Description:Displacement of [3H]-GR113808 from human 5-HT4 receptor expressed in African green monkey COS7 cell membranes after 30 mins by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50142906(CHEMBL3759348)
Affinity DataIC50: 493nMAssay Description:Displacement of [3H]-GR113808 from human 5-HT4 receptor expressed in African green monkey COS7 cell membranes after 30 mins by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50142910(CHEMBL3758945)
Affinity DataIC50: 560nMAssay Description:Displacement of [3H]-GR113808 from human 5-HT4 receptor expressed in African green monkey COS7 cell membranes after 30 mins by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50142903(CHEMBL3759362)
Affinity DataIC50: 592nMAssay Description:Displacement of [3H]-GR113808 from human 5-HT4 receptor expressed in African green monkey COS7 cell membranes after 30 mins by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Dong-A Pharm.

US Patent
LigandPNGBDBM50142924(CHEMBL3758397)
Affinity DataIC50: 593nMAssay Description:Displacement of [3H]-GR113808 from human 5-HT4 receptor expressed in African green monkey COS7 cell membranes after 30 mins by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
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