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Report error Found 1686 of ic50 data for polymerid = 8880
TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252685BDBM252685(US9458176, 82)
Affinity DataIC50: 1.10nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252686BDBM252686(US9458176, 83)
Affinity DataIC50: 1.70nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252846BDBM252846(US9458176, 243)
Affinity DataIC50: 1.70nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252770BDBM252770(US9458176, 167)
Affinity DataIC50: 1.80nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252847BDBM252847(US9458176, 244)
Affinity DataIC50: 1.80nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252612BDBM252612(US9458176, 9)
Affinity DataIC50: 1.90nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252837BDBM252837(US9458176, 234)
Affinity DataIC50: 1.90nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252836BDBM252836(US9458176, 233)
Affinity DataIC50: 2nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 50332966BDBM50332966(7,8-dichloro-4-(3-(2-methylpyridin-4-yl)phenyl)-1H...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 50332962BDBM50332962(7-methyl-4-(3-(pyridin-3-yl)phenyl)-8-(trifluorome...)
Affinity DataIC50: 2nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 50332963BDBM50332963(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Affinity DataIC50: 2nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 50332964BDBM50332964(4-(3-(2-ethyl-6-methylpyridin-4-yl)phenyl)-7-methy...)
Affinity DataIC50: 2nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 50332965BDBM50332965(4-(3-(2-cyclopropyl-6-methylpyridin-4-yl)phenyl)-7...)
Affinity DataIC50: 2nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252804BDBM252804(US9458176, 201)
Affinity DataIC50: 2.40nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252834BDBM252834(US9458176, 231)
Affinity DataIC50: 2.40nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252845BDBM252845(US9458176, 242)
Affinity DataIC50: 2.40nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252642BDBM252642(US9458176, 39)
Affinity DataIC50: 2.5nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252638BDBM252638(US9458176, 35)
Affinity DataIC50: 2.70nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252619BDBM252619(US9458176, 16)
Affinity DataIC50: 2.70nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252637BDBM252637(US9458176, 34)
Affinity DataIC50: 2.80nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252635BDBM252635(US9458176, 32)
Affinity DataIC50: 2.80nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 50062522BDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataIC50: 2.90nMAssay Description:Displacement of [3H]-MGS0008 from mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252844BDBM252844(US9458176, 241)
Affinity DataIC50: 2.90nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252839BDBM252839(US9458176, 236)
Affinity DataIC50: 2.90nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252756BDBM252756(US9458176, 153)
Affinity DataIC50: 3nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
Eisai R&D Management

US Patent
LigandChemical structure of BindingDB Monomer ID 50332962BDBM50332962(7-methyl-4-(3-(pyridin-3-yl)phenyl)-8-(trifluorome...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eisai R&D Management

US Patent
LigandChemical structure of BindingDB Monomer ID 50332963BDBM50332963(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eisai R&D Management

US Patent
LigandChemical structure of BindingDB Monomer ID 252622BDBM252622(US9458176, 19)
Affinity DataIC50: 3nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 50332967BDBM50332967(8-chloro-4-(3-(pyridin-4-yl)phenyl)-1H-benzo[b][1,...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eisai R&D Management

US Patent
LigandChemical structure of BindingDB Monomer ID 252701BDBM252701(US9458176, 98)
Affinity DataIC50: 3.10nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252628BDBM252628(US9458176, 25)
Affinity DataIC50: 3.20nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252623BDBM252623(US9458176, 20)
Affinity DataIC50: 3.40nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 50376408BDBM50376408(CHEMBL409928)
Affinity DataIC50: 3.49nMAssay Description:Displacement of [3H]-MGS0008 from mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eisai R&D Management

US Patent
LigandChemical structure of BindingDB Monomer ID 252630BDBM252630(US9458176, 27)
Affinity DataIC50: 3.5nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252798BDBM252798(US9458176, 195)
Affinity DataIC50: 3.70nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252799BDBM252799(US9458176, 196)
Affinity DataIC50: 3.80nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252620BDBM252620(US9458176, 17)
Affinity DataIC50: 3.80nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252681BDBM252681(US9458176, 78)
Affinity DataIC50: 3.80nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 252632BDBM252632(US9458176, 29)
Affinity DataIC50: 3.80nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
Eisai R&D Management

US Patent
LigandChemical structure of BindingDB Monomer ID 252828BDBM252828(US9458176, 225)
Affinity DataIC50: 3.90nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
Eisai R&D Management

US Patent
LigandChemical structure of BindingDB Monomer ID 252764BDBM252764(US9458176, 161)
Affinity DataIC50: 4nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
Eisai R&D Management

US Patent
LigandChemical structure of BindingDB Monomer ID 50376487BDBM50376487(CHEMBL261050)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eisai R&D Management

US Patent
LigandChemical structure of BindingDB Monomer ID 213143BDBM213143(US9278960, 8-50 | US9636337, 8-50)
Affinity DataIC50: 4nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
Eisai R&D Management

US Patent
LigandChemical structure of BindingDB Monomer ID 50332969BDBM50332969(7-methyl-4-(3-(pyridin-4-yl)phenyl)-8-(trifluorome...)
Affinity DataIC50: 4nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eisai R&D Management

US Patent
LigandChemical structure of BindingDB Monomer ID 50332970BDBM50332970(7-methyl-4-(3-(2-methylpyridin-4-yl)phenyl)-8-(tri...)
Affinity DataIC50: 4nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eisai R&D Management

US Patent
LigandChemical structure of BindingDB Monomer ID 50332971BDBM50332971(4-(3-(2-isopropylpyridin-4-yl)phenyl)-7-methyl-8-(...)
Affinity DataIC50: 4nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eisai R&D Management

US Patent
LigandChemical structure of BindingDB Monomer ID 50332965BDBM50332965(4-(3-(2-cyclopropyl-6-methylpyridin-4-yl)phenyl)-7...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eisai R&D Management

US Patent
LigandChemical structure of BindingDB Monomer ID 252807BDBM252807(US9458176, 204)
Affinity DataIC50: 4nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 50332972BDBM50332972(7-ethoxy-4-(3-(pyridin-4-yl)phenyl)-8-(trifluorome...)
Affinity DataIC50: 4nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Eisai R&D Management

US Patent
LigandChemical structure of BindingDB Monomer ID 50332966BDBM50332966(7,8-dichloro-4-(3-(2-methylpyridin-4-yl)phenyl)-1H...)
Affinity DataIC50: 4nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
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