Compile Data Set for Download or QSAR
Report error Found 235 of ec50 for UniProtKB: P08913
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataEC50:  0.617nMAssay Description:Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2018
Entry Details
PDB3D3D Structure (crystal)
LigandPNGBDBM50052880(Imidazolidin-2-ylidene-(5-methyl-quinoxalin-6-yl)-...)
Affinity DataEC50:  1.20nMAssay Description:Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2018
Entry Details

LigandPNGBDBM50212995(CHEMBL75030)
Affinity DataEC50:  1.20nMAssay Description:Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2018
Entry Details

LigandPNGBDBM50085683(4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole ...)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50212997(CHEMBL310335)
Affinity DataEC50:  1.60nMAssay Description:Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2018
Entry Details

LigandPNGBDBM50473228(AGN-190837 | CHEMBL297752)
Affinity DataEC50:  1.60nMAssay Description:Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50085683(4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole ...)
Affinity DataEC50:  2.10nMAssay Description:Agonist activity at recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane incubated for 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
LigandPNGBDBM50213348(CHEMBL72753)
Affinity DataEC50:  2.30nMAssay Description:Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2018
Entry Details

LigandPNGBDBM50213028(CHEMBL74283)
Affinity DataEC50:  2.80nMAssay Description:Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2018
Entry Details

TargetAlpha-2A adrenergic/Mu-type opioid receptor(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50000092(Analog of 14-(Arylhydroxyamino)codeinone | 4-methy...)
Affinity DataEC50:  3nMAssay Description:Inhibition of MOR/alpha2A adrenergic receptor heterodimer expressed in HEK293 cells assessed as stimulation of ERK1/2 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
LigandPNGBDBM30712(SMR000059324 | Oxymetazoline | cid_66259 | 6-tert-...)
Affinity DataEC50:  3.30nMAssay Description:Agonist potency at Alpha-2A stably expressed in CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataEC50:  4.10nMAssay Description:Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50019646(CHEMBL17860 | lofexidine | 2-(alpha-(2,6-Dichlorop...)
Affinity DataEC50:  6.30nMAssay Description:Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50473665(CHEMBL70751)
Affinity DataEC50:  6.30nMAssay Description:Agonist potency at Alpha-2A stably expressed in CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-2-imidazoline | 2-(2,6-dic...)
Affinity DataEC50:  8.10nMAssay Description:Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2018
Entry Details

LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-2-imidazoline | 2-(2,6-dic...)
Affinity DataEC50:  8.30nMAssay Description:Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataEC50:  8.5nMAssay Description:Displacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
LigandPNGBDBM50055832((1H-Imidazol-2-yl)-(5-methyl-2,3-dihydro-benzo[1,4...)
Affinity DataEC50:  8.70nMAssay Description:Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50635391(CHEMBL5555089)
Affinity DataEC50:  10nMAssay Description:Displacement of [3H]-yohimbine from human ADRA2A adrenergic receptor overexpressed in rat Chem-1 cells measured after 30 mins by microbeta2 liquid sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50213347(CHEMBL70676)
Affinity DataEC50:  11nMAssay Description:Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2018
Entry Details

LigandPNGBDBM50635381(CHEMBL5558621)
Affinity DataEC50:  11nMAssay Description:Displacement of [3H]-yohimbine from human ADRA2A adrenergic receptor overexpressed in rat Chem-1 cells measured after 30 mins by microbeta2 liquid sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50473224(CHEMBL296660)
Affinity DataEC50:  11nMAssay Description:Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50419884(CHEMBL157955)
Affinity DataEC50:  12nMAssay Description:Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50635400(CHEMBL5532522)
Affinity DataEC50:  12nMAssay Description:Displacement of [3H]-yohimbine from human ADRA2A adrenergic receptor overexpressed in rat Chem-1 cells measured after 30 mins by microbeta2 liquid sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50635392(CHEMBL5512567)
Affinity DataEC50:  13nMAssay Description:Displacement of [3H]-yohimbine from human ADRA2A adrenergic receptor overexpressed in rat Chem-1 cells measured after 30 mins by microbeta2 liquid sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50334196(3-[(Imidazolidin-2-yl)imino]-4-methylindazole hydr...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50635399(CHEMBL5505942)
Affinity DataEC50:  14nMAssay Description:Displacement of [3H]-yohimbine from human ADRA2A adrenergic receptor overexpressed in rat Chem-1 cells measured after 30 mins by microbeta2 liquid sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataEC50:  15nMAssay Description:Displacement of [3H]-yohimbine from human ADRA2A adrenergic receptor overexpressed in rat Chem-1 cells measured after 30 mins by microbeta2 liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50334201(7-Cl-Marsanidine | CHEMBL1641690)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50635395(CHEMBL5532116)
Affinity DataEC50:  15nMAssay Description:Displacement of [3H]-yohimbine from human ADRA2A adrenergic receptor overexpressed in rat Chem-1 cells measured after 30 mins by microbeta2 liquid sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50635394(CHEMBL5558449)
Affinity DataEC50:  16nMAssay Description:Displacement of [3H]-yohimbine from human ADRA2A adrenergic receptor overexpressed in rat Chem-1 cells measured after 30 mins by microbeta2 liquid sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50635398(CHEMBL5558450)
Affinity DataEC50:  17nMAssay Description:Displacement of [3H]-yohimbine from human ADRA2A adrenergic receptor overexpressed in rat Chem-1 cells measured after 30 mins by microbeta2 liquid sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50419889(CHEMBL155866)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50635397(CHEMBL5559060)
Affinity DataEC50:  20nMAssay Description:Displacement of [3H]-yohimbine from human ADRA2A adrenergic receptor overexpressed in rat Chem-1 cells measured after 30 mins by microbeta2 liquid sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50635383(CHEMBL5517823)
Affinity DataEC50:  21nMAssay Description:Displacement of [3H]-yohimbine from human ADRA2A adrenergic receptor overexpressed in rat Chem-1 cells measured after 30 mins by microbeta2 liquid sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50635386(CHEMBL5555198)
Affinity DataEC50:  22nMAssay Description:Displacement of [3H]-yohimbine from human ADRA2A adrenergic receptor overexpressed in rat Chem-1 cells measured after 30 mins by microbeta2 liquid sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50635401(CHEMBL5558127)
Affinity DataEC50:  22nMAssay Description:Displacement of [3H]-yohimbine from human ADRA2A adrenergic receptor overexpressed in rat Chem-1 cells measured after 30 mins by microbeta2 liquid sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50635384(CHEMBL5559513)
Affinity DataEC50:  24nMAssay Description:Displacement of [3H]-yohimbine from human ADRA2A adrenergic receptor overexpressed in rat Chem-1 cells measured after 30 mins by microbeta2 liquid sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50635402(CHEMBL5555776)
Affinity DataEC50:  25nMAssay Description:Displacement of [3H]-yohimbine from human ADRA2A adrenergic receptor overexpressed in rat Chem-1 cells measured after 30 mins by microbeta2 liquid sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50473672(CHEMBL72768)
Affinity DataEC50:  25nMAssay Description:Agonist potency at Alpha-2A stably expressed in CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50473677(CHEMBL72441)
Affinity DataEC50:  25nMAssay Description:Agonist potency at Alpha-2A stably expressed in CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50635396(CHEMBL5559006)
Affinity DataEC50:  26nMAssay Description:Displacement of [3H]-yohimbine from human ADRA2A adrenergic receptor overexpressed in rat Chem-1 cells measured after 30 mins by microbeta2 liquid sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50377391(CHEMBL402388)
Affinity DataEC50:  27nMAssay Description:Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-2-imidazoline | 2-(2,6-dic...)
Affinity DataEC50:  28nMAssay Description:Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-2-imidazoline | 2-(2,6-dic...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane incubated for 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane incubated for 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-2-imidazoline | 2-(2,6-dic...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50419883(CHEMBL1956201)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50473231(CHEMBL48341)
Affinity DataEC50:  35nMAssay Description:Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50270556(CHEMBL478356 | CHEMBL1186788 | 1-[(Imidazolidin-2-...)
Affinity DataEC50:  37nMAssay Description:Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
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