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Found 12656 of ic50 for UniProtKB: P52333
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM350321((S)-3-(1-((1-acryloylpyrrolidin-3-yl)oxy)isoquinol...)
Affinity DataIC50:  0nMAssay Description:Inhibition of human Jak3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM555569(US11344549, Example 245)
Affinity DataIC50:  0nMAssay Description:JAK3 (the final concentration was 0.36 nM); ATP (the final concentration was 10 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112574(US8618103, I-70)
Affinity DataKi:  0.000578nM IC50:  0.00115nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112546(US8618103, I-42)
Affinity DataKi:  0.000748nM IC50:  0.00149nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112576(US8618103, I-72)
Affinity DataKi:  0.000940nM IC50:  0.00188nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112573(US8618103, I-69)
Affinity DataKi:  0.000980nM IC50:  0.00196nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112601(US8618103, I-97)
Affinity DataKi:  0.00109nM IC50:  0.00218nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112536(US8618103, I-32)
Affinity DataKi:  0.00120nM IC50:  0.00240nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112583(US8618103, I-79)
Affinity DataKi:  0.00121nM IC50:  0.00242nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112616(US8618103, I-112)
Affinity DataKi:  0.00207nM IC50:  0.00415nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112568(US8618103, I-64)
Affinity DataKi:  0.00210nM IC50:  0.00421nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112575(US8618103, I-71)
Affinity DataKi:  0.00248nM IC50:  0.00496nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112615(US8618103, I-111)
Affinity DataKi:  0.0163nM IC50:  0.00519nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112622(US8618103, I-118)
Affinity DataKi:  0.00260nM IC50:  0.00521nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112597(US8618103, I-93)
Affinity DataKi:  0.00265nM IC50:  0.00530nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112530(US8618103, I-26)
Affinity DataKi:  0.00344nM IC50:  0.00670nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112614(US8618103, I-110)
Affinity DataKi:  0.00337nM IC50:  0.00675nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112542(US8618103, I-38)
Affinity DataKi:  0.00373nM IC50:  0.00747nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112569(US8618103, I-65)
Affinity DataKi:  0.00380nM IC50:  0.00762nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112567(US8618103, I-63)
Affinity DataKi:  0.00386nM IC50:  0.00773nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112529(US8618103, I-25)
Affinity DataKi:  0.00398nM IC50:  0.00776nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112589(US8618103, I-85)
Affinity DataKi:  0.00402nM IC50:  0.00805nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112506(US8618103, I-2)
Affinity DataKi:  0.00429nM IC50:  0.00837nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112599(US8618103, I-95)
Affinity DataKi:  0.00429nM IC50:  0.00858nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112577(US8618103, I-73)
Affinity DataKi:  0.00448nM IC50:  0.00897nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112509(US8618103, I-5)
Affinity DataKi:  0.00537nM IC50:  0.0105nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112578(US8618103, I-74)
Affinity DataKi:  0.00525nM IC50:  0.0105nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112590(US8618103, I-86)
Affinity DataKi:  0.00535nM IC50:  0.0107nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112598(US8618103, I-94)
Affinity DataKi:  0.00548nM IC50:  0.0110nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112565(US8618103, I-61)
Affinity DataKi:  0.00587nM IC50:  0.0117nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112606(US8618103, I-102)
Affinity DataKi:  0.00625nM IC50:  0.0125nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112510(US8618103, I-6)
Affinity DataKi:  0.00657nM IC50:  0.0128nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM153198(US8993756, 5-10)
Affinity DataIC50:  0.0130nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM153166(US8993756, 4-9)
Affinity DataIC50:  0.0130nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112607(US8618103, I-103)
Affinity DataKi:  0.00679nM IC50:  0.0136nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112605(US8618103, I-101)
Affinity DataKi:  0.00756nM IC50:  0.0151nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112586(US8618103, I-82)
Affinity DataKi:  0.0106nM IC50:  0.0156nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM153227(US10421760, Comparative Example 12 | US8993756, 20...)
Affinity DataIC50:  0.0160nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112540(US8618103, I-36)
Affinity DataKi:  0.00838nM IC50:  0.0168nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112587(US8618103, I-83)
Affinity DataKi:  0.00860nM IC50:  0.0172nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112564(US8618103, I-60)
Affinity DataKi:  0.00867nM IC50:  0.0174nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112581(US8618103, I-77)
Affinity DataKi:  0.00893nM IC50:  0.0179nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112515(US8618103, I-11)
Affinity DataKi:  0.00920nM IC50:  0.0179nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112591(US8618103, I-87)
Affinity DataKi:  0.00931nM IC50:  0.0186nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)
Affinity DataIC50:  0.0192nMpH: 7.5 T: 2°CAssay Description:Briefly, specific kinase/substrate pairs along with required cofactors were prepared in reaction buffer. Compounds were delivered into the reaction, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112535(US8618103, I-31)
Affinity DataKi:  0.00969nM IC50:  0.0194nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM47231(US8993756, 16)
Affinity DataIC50:  0.0200nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM153218(US8993756, 15-2)
Affinity DataIC50:  0.0200nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112533(US8618103, I-29)
Affinity DataKi:  0.0105nM IC50:  0.0204nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM112566(US8618103, I-62)
Affinity DataKi:  0.0107nM IC50:  0.0215nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
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