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Report error Found 19308 of ic50 for UniProtKB: O60885
TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623611(CHEMBL5424952)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4 [349-460](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM684555(US12030880, Example 21)
Affinity DataIC50: 0.130nMAssay Description:In the present application, IC50 values of the compounds in inhibiting BRD4 (BD2) enzyme binding reaction were determined by homogeneous time resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Poseidon Innovation 1

US Patent
LigandPNGBDBM684597(US20240226096, Example I-15 | 1-(3'-(5-(4-(tert- b...)
Affinity DataIC50: 0.152nMAssay Description:3x Complete Substrate plus Inhibitor Solution in Assay Medium (Opti-MEM I Reduced Serum Medium, no phenol red, and no serum) was prepared just before...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Poseidon Innovation 1

US Patent
LigandPNGBDBM684583(US20240226096, Example I-2 | US20240226096, Exampl...)
Affinity DataIC50: 0.152nMAssay Description:3x Complete Substrate plus Inhibitor Solution in Assay Medium (Opti-MEM I Reduced Serum Medium, no phenol red, and no serum) was prepared just before...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623615(CHEMBL5432745)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623606(CHEMBL5440537)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM223491(US9320741, JQ6 | US10407441, Compound JQ6 | US1092...)
Affinity DataIC50: 0.240nMpH: 7.4 T: 2°CAssay Description:BRD4(2): Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [349-460](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM223491(US9320741, JQ6 | US10407441, Compound JQ6 | US1092...)
Affinity DataIC50: 0.240nMAssay Description:The binding activity of lead compounds with the BRD4 site 2 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Poseidon Innovation 1

US Patent
LigandPNGBDBM223491(US9320741, JQ6 | US10407441, Compound JQ6 | US1092...)
Affinity DataIC50: 0.240nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
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TargetBromodomain-containing protein 4 [368-440](Human)
Poseidon Innovation 1

US Patent
LigandPNGBDBM661115(US20240101551, Compound of Formula I)
Affinity DataIC50: 0.25nMAssay Description:In the present application, the IC50 value of the compound of formula (I) in inhibiting BRD4 (BD1) enzyme binding reaction were determined by homogen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
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TargetBromodomain-containing protein 4 [349-460](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM684552(US12030880, Example 18)
Affinity DataIC50: 0.25nMAssay Description:In the present application, IC50 values of the compounds in inhibiting BRD4 (BD2) enzyme binding reaction were determined by homogeneous time resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [349-460](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM684554(US12030880, Example 20)
Affinity DataIC50: 0.270nMAssay Description:In the present application, IC50 values of the compounds in inhibiting BRD4 (BD2) enzyme binding reaction were determined by homogeneous time resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575844(US11466005, Compound 16 | 6-(1,4-Dimethyl-1H-1,2,3...)
Affinity DataIC50: 0.300nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623605(CHEMBL5401253)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623607(CHEMBL5440963)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4 [368-440](Human)
Poseidon Innovation 1

US Patent
LigandPNGBDBM684582(US20240226096, Example I-1 | 1-(3$#8243;-(4-(tert-...)
Affinity DataIC50: 0.323nMAssay Description:3x Complete Substrate plus Inhibitor Solution in Assay Medium (Opti-MEM I Reduced Serum Medium, no phenol red, and no serum) was prepared just before...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50604593(CHEMBL5171062)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of C-terminal His6-tagged BRD4 BD1 (unknown origin) using H-YSGRGK(Ac)GGK(Ac)GLGK(Ac)-GGAK(Ac)RHRK-Biotin-OH as substrate incubated for 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575868(US11466005, Compound 34 | 4-((6-(1,4-dimethyl-1H-1...)
Affinity DataIC50: 0.340nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [349-460](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM684542(US12030880, Example 7)
Affinity DataIC50: 0.340nMAssay Description:In the present application, IC50 values of the compounds in inhibiting BRD4 (BD2) enzyme binding reaction were determined by homogeneous time resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50604616(CHEMBL5206375)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of C-terminal His6-tagged BRD4 BD2 (unknown origin) using H-YSGRGK(Ac)GGK(Ac)GLGK(Ac)-GGAK(Ac)RHRK-Biotin-OH as substrate incubated for 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575845(US11466005, Compound 2 | (S)-2-(6-(3,5-dimethyliso...)
Affinity DataIC50: 0.350nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [349-460](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM684529(US12030880, Example 4)
Affinity DataIC50: 0.350nMAssay Description:In the present application, IC50 values of the compounds in inhibiting BRD4 (BD2) enzyme binding reaction were determined by homogeneous time resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50604589(CHEMBL5171510)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of C-terminal His6-tagged BRD4 BD1 (unknown origin) using H-YSGRGK(Ac)GGK(Ac)GLGK(Ac)-GGAK(Ac)RHRK-Biotin-OH as substrate incubated for 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of human BRD4 bromodomain 1 by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of human BRD4 bromodomain 1/2 by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM502377(N-[4-(7- methoxy-1- methyl- [1,2,4]tri- azolo[4,3-...)
Affinity DataIC50: 0.400nMAssay Description:The following experiment was performed to evaluate the ability of [1,2,4]triazolo[4,3-a]quinoxaline derivative of the present invention to inhibit th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
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TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575867(US11466005, Compound 13 | (S)-2-(6-(1,4-Dimethyl-1...)
Affinity DataIC50: 0.400nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623610(CHEMBL5422881)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4 [349-460](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM684550(US12030880, Example 16)
Affinity DataIC50: 0.400nMAssay Description:In the present application, IC50 values of the compounds in inhibiting BRD4 (BD2) enzyme binding reaction were determined by homogeneous time resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [349-460](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM576088(N-(1-(4-chlorobenzyl)-2- methyl-6-(6-methyl-7-oxo-...)
Affinity DataIC50: 0.400nMAssay Description:The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50605409(CHEMBL5209870)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of BRD4 (unknown origin) incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM445527(US10683290, Example 19 | 2-[7-(Dimethyl-1H-1,2,3-t...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50604610(CHEMBL5171031)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of C-terminal His6-tagged BRD4 BD2 (unknown origin) using H-YSGRGK(Ac)GGK(Ac)GLGK(Ac)-GGAK(Ac)RHRK-Biotin-OH as substrate incubated for 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50407714(CHEMBL5269983)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of poly His-tagged BRD4 BD2 (unknown origin) (348 to 455 residues) by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM223492(US9320741, JQ8 | US10407441, Compound JQ8 | US1092...)
Affinity DataIC50: 0.427nMpH: 7.4 T: 2°CAssay Description:BRD4(2): Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Poseidon Innovation 1

US Patent
LigandPNGBDBM223492(US9320741, JQ8 | US10407441, Compound JQ8 | US1092...)
Affinity DataIC50: 0.427nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [349-460](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM223492(US9320741, JQ8 | US10407441, Compound JQ8 | US1092...)
Affinity DataIC50: 0.427nMAssay Description:The binding activity of lead compounds with the BRD4 site 2 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50604602(CHEMBL5176955)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of C-terminal His6-tagged BRD4 BD1 (unknown origin) using H-YSGRGK(Ac)GGK(Ac)GLGK(Ac)-GGAK(Ac)RHRK-Biotin-OH as substrate incubated for 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4 [349-460](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM684528(US12030880, Example 3)
Affinity DataIC50: 0.450nMAssay Description:In the present application, IC50 values of the compounds in inhibiting BRD4 (BD2) enzyme binding reaction were determined by homogeneous time resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50604601(CHEMBL5177436)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of C-terminal His6-tagged BRD4 BD2 (unknown origin) using H-YSGRGK(Ac)GGK(Ac)GLGK(Ac)-GGAK(Ac)RHRK-Biotin-OH as substrate incubated for 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50604627(CHEMBL5192071)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of C-terminal His6-tagged BRD4 BD2 (unknown origin) using H-YSGRGK(Ac)GGK(Ac)GLGK(Ac)-GGAK(Ac)RHRK-Biotin-OH as substrate incubated for 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4 [368-440](Human)
Poseidon Innovation 1

US Patent
LigandPNGBDBM684586(US20240226096, Example I-5 | 1-(4-(3-amino-2-(3- (...)
Affinity DataIC50: 0.473nMAssay Description:3x Complete Substrate plus Inhibitor Solution in Assay Medium (Opti-MEM I Reduced Serum Medium, no phenol red, and no serum) was prepared just before...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575781(US11466005, Compound 1 | (S)-2-(6-(3,5-dimethyliso...)
Affinity DataIC50: 0.480nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575853(US11466005, Compound 6 | (S)-2-(6-(1,4-dimethyl-1H...)
Affinity DataIC50: 0.490nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50604611(CHEMBL5175082)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of C-terminal His6-tagged BRD4 BD2 (unknown origin) using H-YSGRGK(Ac)GGK(Ac)GLGK(Ac)-GGAK(Ac)RHRK-Biotin-OH as substrate incubated for 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50604602(CHEMBL5176955)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of C-terminal His6-tagged BRD4 BD2 (unknown origin) using H-YSGRGK(Ac)GGK(Ac)GLGK(Ac)-GGAK(Ac)RHRK-Biotin-OH as substrate incubated for 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50260101(CHEMBL4068487 | US10689390, Compound 38 | US113193...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BRD4 bromodomain 1 (unknown origin) using biotinylated substrate after 1 hr by AlphaLisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [349-460](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM576114(N-(3-(2,4-difluorobenzyl)-2- methyl-5-(6-methyl-7-...)
Affinity DataIC50: 0.5nMAssay Description:The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [349-460](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM576106(N-(5-(6-methyl-7-oxo-6,7- dihydro-1H-pyrrolo[2,3-c...)
Affinity DataIC50: 0.5nMAssay Description:The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50604614(CHEMBL5172345)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of C-terminal His6-tagged BRD4 BD2 (unknown origin) using H-YSGRGK(Ac)GGK(Ac)GLGK(Ac)-GGAK(Ac)RHRK-Biotin-OH as substrate incubated for 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
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