Compile Data Set for Download or QSAR
maximum 50k data
Found 42 of ec50 data for complexid = 50000023
LigandPNGBDBM50139706(3-(2,4-Dinitro-phenyl)-4-nitro-5-trifluoromethyl-1...)
Affinity DataEC50:  70nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378565(CHEMBL568795)
Affinity DataEC50:  80nMAssay Description:Activation of human recombinant SUR1/Kir6.2 channel expressed in HEK293 cells assessed as increase in ionic current by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50190502(6-bromo-3-(1-methylcyclopropyl)amino-4H-thieno[3,2...)
Affinity DataEC50:  160nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50190500(6-chloro-3-(1-methyl-1-phenylethyl)amino-4H-thieno...)
Affinity DataEC50:  180nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataEC50:  190nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataEC50:  190nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119272((7-Chloro-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1...)
Affinity DataEC50:  196nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119272((7-Chloro-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1...)
Affinity DataEC50:  200nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130735((7-Chloro-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1...)
Affinity DataEC50:  250nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119269(CHEMBL102025 | Cyclobutyl-(7-fluoro-1,1-dioxo-1,4-...)
Affinity DataEC50:  356nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119269(CHEMBL102025 | Cyclobutyl-(7-fluoro-1,1-dioxo-1,4-...)
Affinity DataEC50:  400nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataEC50:  450nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as activation of K+ currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50190501(6-chloro-3-{[1-(trifluoromethyl)cyclopropyl]-amino...)
Affinity DataEC50:  530nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119274(CHEMBL100793 | Cyclobutyl-(7-nitro-1,1-dioxo-1,4-d...)
Affinity DataEC50:  530nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50139709(3-(2,4-Bis-trifluoromethyl-phenyl)-4-nitro-5-trifl...)
Affinity DataEC50:  540nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50139705(4-Nitro-3-(4-nitro-phenyl)-5-trifluoromethyl-1H-py...)
Affinity DataEC50:  700nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50190496(6-chloro-3-(1-phenylcyclopropyl)amino-4H-thieno[3,...)
Affinity DataEC50:  810nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50139704(3-(2,4-Difluoro-phenyl)-4-nitro-5-trifluoromethyl-...)
Affinity DataEC50:  1.15E+3nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119270(CHEMBL319596 | Cyclobutyl-(1,1-dioxo-1,4-dihydro-1...)
Affinity DataEC50:  1.96E+3nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119270(CHEMBL319596 | Cyclobutyl-(1,1-dioxo-1,4-dihydro-1...)
Affinity DataEC50:  2.00E+3nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119271(CHEMBL319521 | Cyclobutyl-(7-methoxy-1,1-dioxo-1,4...)
Affinity DataEC50:  3.87E+3nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119271(CHEMBL319521 | Cyclobutyl-(7-methoxy-1,1-dioxo-1,4...)
Affinity DataEC50:  4.00E+3nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86248(CAS_364-98-7 | NSC_3019 | diazoxide)
Affinity DataEC50:  8.80E+3nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86248(CAS_364-98-7 | NSC_3019 | diazoxide)
Affinity DataEC50:  8.80E+3nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50210319(4-amino-6-methoxy-2-(trifluoromethyl)quinoline-3-c...)
Affinity DataEC50:  1.50E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50210320(CHEMBL226918 | [(2Z)-4-(4-fluorophenyl)-2-[(4-fluo...)
Affinity DataEC50:  2.10E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86248(CAS_364-98-7 | NSC_3019 | diazoxide)
Affinity DataEC50:  2.35E+4nMAssay Description:Activation of human recombinant SUR1/Kir6.2 channel expressed in HEK293 cells assessed as increase in ionic current by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM56470(2-(2-Imino-3-methyl-2,3-dihydro-benzoimidazol-1-yl...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50210325(3-oxo-5,6-diphenyl-2,3-dihydropyridazine-4-carboni...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50210323(2-{[(4-chlorophenyl)sulfonyl]amino}benzamide | CHE...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50210324(6-phenylpteridin-4(3H)-one | CHEMBL228035)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50210322(CHEMBL374743 | N-[1-(2-pyrrolidin-1-ylethyl)-1H-be...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50210321(5-methoxy-2-piperidin-1-yl-1H-benzimidazole | CHEM...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50210318(6-chloro-4-hydroxy-2-oxo-N-1,3-thiazol-2-yl-2H-chr...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50139707(4-Nitro-3-(4-nitro-phenyl)-5-trifluoromethyl-isoxa...)
Affinity DataEC50: >3.00E+4nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50139710(4-Nitro-3-phenyl-5-trifluoromethyl-1H-pyrazole | C...)
Affinity DataEC50:  3.00E+4nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50139708(3-(4-Nitro-phenyl)-5-trifluoromethyl-1H-pyrazole |...)
Affinity DataEC50: >3.00E+4nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86248(CAS_364-98-7 | NSC_3019 | diazoxide)
Affinity DataEC50:  3.10E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as activation of K+ currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119273(CHEMBL101736 | N*3*-Cyclobutyl-1,1-dioxo-1,4-dihyd...)
Affinity DataEC50:  3.10E+4nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119273(CHEMBL101736 | N*3*-Cyclobutyl-1,1-dioxo-1,4-dihyd...)
Affinity DataEC50:  3.20E+4nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86248(CAS_364-98-7 | NSC_3019 | diazoxide)
Affinity DataEC50:  3.30E+4nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86248(CAS_364-98-7 | NSC_3019 | diazoxide)
Affinity DataEC50:  3.30E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed