Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 7645
TargetAcyl-protein thioesterase 2 [S122A](Human)
University of Michigan

LigandPNGBDBM207993(ML349-FL)
Affinity DataKd:  770nMT: 2°CAssay Description:Varying amounts of enzyme were diluted in PBS supplemented with 0.5 g/L pluronic F127 and incubated with 500 nM ML349-FL for 30 minutes at room tempe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

LigandPNGBDBM207993(ML349-FL)
Affinity DataKd:  1.02E+3nMT: 2°CAssay Description:Varying amounts of enzyme were diluted in PBS supplemented with 0.5 g/L pluronic F127 and incubated with 500 nM ML349-FL for 30 minutes at room tempe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2 [S122A](Human)
University of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataIC50: 1.00E+3nM Kd:  160nMT: 2°CAssay Description:Varying amounts of enzyme were diluted in PBS supplemented with 0.5 g/L pluronic F127 and incubated with 500 nM ML349-FL for 30 minutes at room tempe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataIC50: 1.10E+3nM Kd:  240nMT: 2°CAssay Description:Varying amounts of enzyme were diluted in PBS supplemented with 0.5 g/L pluronic F127 and incubated with 500 nM ML349-FL for 30 minutes at room tempe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2 [S122A](Human)
University of Michigan

LigandPNGBDBM207994(ML349-sulfoxide)
Affinity DataIC50: 7.10E+3nM Kd:  2.60E+3nMT: 2°CAssay Description:Varying amounts of enzyme were diluted in PBS supplemented with 0.5 g/L pluronic F127 and incubated with 500 nM ML349-FL for 30 minutes at room tempe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

LigandPNGBDBM207994(ML349-sulfoxide)
Affinity DataIC50: 1.20E+4nM Kd:  5.20E+3nMT: 2°CAssay Description:Varying amounts of enzyme were diluted in PBS supplemented with 0.5 g/L pluronic F127 and incubated with 500 nM ML349-FL for 30 minutes at room tempe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2 [S122A](Human)
University of Michigan

LigandPNGBDBM207995(ML349-thioether)
Affinity DataIC50: 1.00E+5nM Kd: >1.00E+4nMT: 2°CAssay Description:Varying amounts of enzyme were diluted in PBS supplemented with 0.5 g/L pluronic F127 and incubated with 500 nM ML349-FL for 30 minutes at room tempe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

LigandPNGBDBM207995(ML349-thioether)
Affinity DataIC50: 1.00E+5nM Kd: >1.00E+4nMT: 2°CAssay Description:Varying amounts of enzyme were diluted in PBS supplemented with 0.5 g/L pluronic F127 and incubated with 500 nM ML349-FL for 30 minutes at room tempe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataKi:  120nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2 [P86Q](Human)
University of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataKi:  130nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
LigandPNGBDBM207992(ML349)
Affinity DataKi:  180nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2 [M178L](Human)
University of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataKi:  200nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1 [I75L,S82A](Human)
University of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataKi:  280nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1(Human)
University of Michigan

LigandPNGBDBM207991(ML348)
Affinity DataKi:  280nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcyl-protein thioesterase 1 [L176M](Human)
University of Michigan

LigandPNGBDBM207991(ML348)
Affinity DataKi:  340nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcyl-protein thioesterase 1 [Q83P](Human)
University of Michigan

LigandPNGBDBM207991(ML348)
Affinity DataKi:  370nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcyl-protein thioesterase 1 [I75L](Human)
University of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataKi:  370nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
LigandPNGBDBM207991(ML348)
Affinity DataKi:  430nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2 [H152R](Human)
University of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataKi:  660nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1 [I75L,S82A,Q83P](Human)
University of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataKi:  1.20E+3nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1 [I75L,S82A](Human)
University of Michigan

LigandPNGBDBM207991(ML348)
Affinity DataKi:  1.20E+3nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcyl-protein thioesterase 1 [I75L](Human)
University of Michigan

LigandPNGBDBM207991(ML348)
Affinity DataKi:  2.20E+3nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcyl-protein thioesterase 2 [L78I,A85S,P86Q](Human)
University of Michigan

LigandPNGBDBM207991(ML348)
Affinity DataKi:  3.40E+3nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2 [L78I](Human)
University of Michigan

LigandPNGBDBM207991(ML348)
Affinity DataKi:  5.80E+3nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2 [L78I,A85S](Human)
University of Michigan

LigandPNGBDBM207991(ML348)
Affinity DataKi:  6.20E+3nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2 [L78I](Human)
University of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataKi: >1.00E+4nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1 [I75L,S82A,Q83P](Human)
University of Michigan

LigandPNGBDBM207991(ML348)
Affinity DataKi: >1.00E+4nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM207991(ML348)
Affinity DataKi: >1.00E+4nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcyl-protein thioesterase 2(Human)
University of Michigan

LigandPNGBDBM207991(ML348)
Affinity DataKi: >1.00E+4nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2 [M178L](Human)
University of Michigan

LigandPNGBDBM207991(ML348)
Affinity DataKi: >1.00E+4nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
LigandPNGBDBM207992(ML349)
Affinity DataKi: >1.00E+4nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2 [L78I,A85S,P86Q](Human)
University of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataKi: >1.00E+4nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2 [L78I,A85S](Human)
University of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataKi: >1.00E+4nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2 [P86Q](Human)
University of Michigan

LigandPNGBDBM207991(ML348)
Affinity DataKi: >1.00E+4nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2 [H152R](Human)
University of Michigan

LigandPNGBDBM207991(ML348)
Affinity DataKi: >1.00E+4nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1 [Q83P](Human)
University of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataKi: >1.00E+4nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1 [L176M](Human)
University of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataKi: >1.00E+4nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1(Human)
University of Michigan

LigandPNGBDBM207992(ML349)
Affinity DataKi: >1.00E+4nMpH: 6.5Assay Description:Enzymes were diluted to 10 nM in PBS pH 6.5 (adjusted with sodium acetate) supplemented with 0.1 g/L pluronic F127 (Sigma). Varying concentrations of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details Article
PubMed