Compile Data Set for Download or QSAR
Found 33 Enz. Inhib. hit(s) with all data for entry = 50006600
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50051551(6-[Hydrazono-(5,5,8,8-tetramethyl-5,6,7,8-tetrahyd...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(N=N)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C26H28N2O2/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(28-27)18-7-5-17-14-20(24(29)30)8-6-16(17)13-18/h5-10,13-15,23,27H,11-12H2,1-4H3,(H,29,30)
Affinity DataKd:  2.20E+3nMAssay Description:Apparent binding constant against Retinoic acid receptor alpha in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31882(BMS184394-R | CHEMBL80992)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)[C@H](O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C26H28O3/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(27)18-7-5-17-14-20(24(28)29)8-6-16(17)13-18/h5-10,13-15,23,27H,11-12H2,1-4H3,(H,28,29)/t23-/m1/s1
Affinity DataKd:  816nMAssay Description:Apparent binding constant against Retinoic acid receptor gamma in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31882(BMS184394-R | CHEMBL80992)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)[C@H](O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C26H28O3/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(27)18-7-5-17-14-20(24(28)29)8-6-16(17)13-18/h5-10,13-15,23,27H,11-12H2,1-4H3,(H,28,29)/t23-/m1/s1
Affinity DataKd:  4.10E+3nMAssay Description:Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50051552(6-[HYDROXYIMINO-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRA...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(N=O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C26H27NO3/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(27-30)18-7-5-17-14-20(24(28)29)8-6-16(17)13-18/h5-10,13-15,23H,11-12H2,1-4H3,(H,28,29)
Affinity DataKd:  700nMAssay Description:Apparent binding constant against Retinoic acid receptor alpha in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50051553(6-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-napht...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(=C)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C27H28O2/c1-17(18-6-7-21-15-22(25(28)29)9-8-20(21)14-18)19-10-11-23-24(16-19)27(4,5)13-12-26(23,2)3/h6-11,14-16H,1,12-13H2,2-5H3,(H,28,29)
Affinity DataKd:  68nMAssay Description:Apparent binding constant against Retinoic acid receptor alpha in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31885(BMS184394 | CHEMBL82089)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C26H28O3/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(27)18-7-5-17-14-20(24(28)29)8-6-16(17)13-18/h5-10,13-15,23,27H,11-12H2,1-4H3,(H,28,29)
Affinity DataKd:  7.50E+3nMAssay Description:Apparent binding constant against Retinoic acid receptor alpha in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50051554(6-[2,2-Difluoro-1-(5,5,8,8-tetramethyl-5,6,7,8-tet...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(=C(F)F)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C27H26F2O2/c1-26(2)11-12-27(3,4)22-15-19(9-10-21(22)26)23(24(28)29)18-7-5-17-14-20(25(30)31)8-6-16(17)13-18/h5-10,13-15H,11-12H2,1-4H3,(H,30,31)
Affinity DataKd:  73nMAssay Description:Apparent binding constant against Retinoic acid receptor alpha in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31885(BMS184394 | CHEMBL82089)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C26H28O3/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(27)18-7-5-17-14-20(24(28)29)8-6-16(17)13-18/h5-10,13-15,23,27H,11-12H2,1-4H3,(H,28,29)
Affinity DataKd:  679nMAssay Description:Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50051555(6-[methyl sulphonylHydrazono-(5,5,8,8-tetramethyl-...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(=N\NS(C)(=O)=O)\c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C27H30N2O4S/c1-26(2)12-13-27(3,4)23-16-20(10-11-22(23)26)24(28-29-34(5,32)33)19-8-6-18-15-21(25(30)31)9-7-17(18)14-19/h6-11,14-16,29H,12-13H2,1-5H3,(H,30,31)/b28-24+
Affinity DataKd:  1.28E+3nMAssay Description:Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50051551(6-[Hydrazono-(5,5,8,8-tetramethyl-5,6,7,8-tetrahyd...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(N=N)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C26H28N2O2/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(28-27)18-7-5-17-14-20(24(29)30)8-6-16(17)13-18/h5-10,13-15,23,27H,11-12H2,1-4H3,(H,29,30)
Affinity DataKd:  95nMAssay Description:Apparent binding constant against Retinoic acid receptor gamma in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31884(BMS184394-S | CHEMBL81273)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)[C@@H](O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C26H28O3/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(27)18-7-5-17-14-20(24(28)29)8-6-16(17)13-18/h5-10,13-15,23,27H,11-12H2,1-4H3,(H,28,29)/t23-/m0/s1
Affinity DataKd:  75nMAssay Description:Apparent binding constant against Retinoic acid receptor gamma in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
Affinity DataKd:  2.30nMAssay Description:Apparent binding constant against Retinoic acid receptor alpha in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31882(BMS184394-R | CHEMBL80992)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)[C@H](O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C26H28O3/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(27)18-7-5-17-14-20(24(28)29)8-6-16(17)13-18/h5-10,13-15,23,27H,11-12H2,1-4H3,(H,28,29)/t23-/m1/s1
Affinity DataKd:  7.50E+3nMAssay Description:Apparent binding constant against Retinoic acid receptor alpha in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50051555(6-[methyl sulphonylHydrazono-(5,5,8,8-tetramethyl-...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(=N\NS(C)(=O)=O)\c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C27H30N2O4S/c1-26(2)12-13-27(3,4)23-16-20(10-11-22(23)26)24(28-29-34(5,32)33)19-8-6-18-15-21(25(30)31)9-7-17(18)14-19/h6-11,14-16,29H,12-13H2,1-5H3,(H,30,31)/b28-24+
Affinity DataKd:  4.38E+3nMAssay Description:Apparent binding constant against Retinoic acid receptor gamma in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50051556(6-[Methoxy-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro...)
Show SMILES COC(c1ccc2c(c1)C(C)(C)CCC2(C)C)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C27H30O3/c1-26(2)12-13-27(3,4)23-16-20(10-11-22(23)26)24(30-5)19-8-6-18-15-21(25(28)29)9-7-17(18)14-19/h6-11,14-16,24H,12-13H2,1-5H3,(H,28,29)
Affinity DataKd:  250nMAssay Description:Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50051556(6-[Methoxy-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro...)
Show SMILES COC(c1ccc2c(c1)C(C)(C)CCC2(C)C)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C27H30O3/c1-26(2)12-13-27(3,4)23-16-20(10-11-22(23)26)24(30-5)19-8-6-18-15-21(25(28)29)9-7-17(18)14-19/h6-11,14-16,24H,12-13H2,1-5H3,(H,28,29)
Affinity DataKd:  400nMAssay Description:Apparent binding constant against Retinoic acid receptor gamma in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31884(BMS184394-S | CHEMBL81273)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)[C@@H](O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C26H28O3/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(27)18-7-5-17-14-20(24(28)29)8-6-16(17)13-18/h5-10,13-15,23,27H,11-12H2,1-4H3,(H,28,29)/t23-/m0/s1
Affinity DataKd:  1.65E+4nMAssay Description:Apparent binding constant against Retinoic acid receptor alpha in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50051553(6-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-napht...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(=C)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C27H28O2/c1-17(18-6-7-21-15-22(25(28)29)9-8-20(21)14-18)19-10-11-23-24(16-19)27(4,5)13-12-26(23,2)3/h6-11,14-16H,1,12-13H2,2-5H3,(H,28,29)
Affinity DataKd:  1.10nMAssay Description:Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50051555(6-[methyl sulphonylHydrazono-(5,5,8,8-tetramethyl-...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(=N\NS(C)(=O)=O)\c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C27H30N2O4S/c1-26(2)12-13-27(3,4)23-16-20(10-11-22(23)26)24(28-29-34(5,32)33)19-8-6-18-15-21(25(30)31)9-7-17(18)14-19/h6-11,14-16,29H,12-13H2,1-5H3,(H,30,31)/b28-24+
Affinity DataKd:  1.10E+4nMAssay Description:Apparent binding constant against Retinoic acid receptor alpha in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
Affinity DataKd:  0.300nMAssay Description:Apparent binding constant against Retinoic acid receptor gamma in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31885(BMS184394 | CHEMBL82089)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C26H28O3/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(27)18-7-5-17-14-20(24(28)29)8-6-16(17)13-18/h5-10,13-15,23,27H,11-12H2,1-4H3,(H,28,29)
Affinity DataKd:  64nMAssay Description:Apparent binding constant against Retinoic acid receptor gamma in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50051552(6-[HYDROXYIMINO-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRA...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(N=O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C26H27NO3/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(27-30)18-7-5-17-14-20(24(28)29)8-6-16(17)13-18/h5-10,13-15,23H,11-12H2,1-4H3,(H,28,29)
Affinity DataKd:  50nMAssay Description:Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50051554(6-[2,2-Difluoro-1-(5,5,8,8-tetramethyl-5,6,7,8-tet...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(=C(F)F)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C27H26F2O2/c1-26(2)11-12-27(3,4)22-15-19(9-10-21(22)26)23(24(28)29)18-7-5-17-14-20(25(30)31)8-6-16(17)13-18/h5-10,13-15H,11-12H2,1-4H3,(H,30,31)
Affinity DataKd:  1.70nMAssay Description:Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31884(BMS184394-S | CHEMBL81273)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)[C@@H](O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C26H28O3/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(27)18-7-5-17-14-20(24(28)29)8-6-16(17)13-18/h5-10,13-15,23,27H,11-12H2,1-4H3,(H,28,29)/t23-/m0/s1
Affinity DataKd:  531nMAssay Description:Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50051553(6-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-napht...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(=C)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C27H28O2/c1-17(18-6-7-21-15-22(25(28)29)9-8-20(21)14-18)19-10-11-23-24(16-19)27(4,5)13-12-26(23,2)3/h6-11,14-16H,1,12-13H2,2-5H3,(H,28,29)
Affinity DataKd:  1.30nMAssay Description:Apparent binding constant against Retinoic acid receptor gamma in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50051552(6-[HYDROXYIMINO-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRA...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(N=O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C26H27NO3/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(27-30)18-7-5-17-14-20(24(28)29)8-6-16(17)13-18/h5-10,13-15,23H,11-12H2,1-4H3,(H,28,29)
Affinity DataKd:  3.30nMAssay Description:Apparent binding constant against Retinoic acid receptor gamma in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50051556(6-[Methoxy-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro...)
Show SMILES COC(c1ccc2c(c1)C(C)(C)CCC2(C)C)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C27H30O3/c1-26(2)12-13-27(3,4)23-16-20(10-11-22(23)26)24(30-5)19-8-6-18-15-21(25(28)29)9-7-17(18)14-19/h6-11,14-16,24H,12-13H2,1-5H3,(H,28,29)
Affinity DataKd:  6.50E+3nMAssay Description:Apparent binding constant against Retinoic acid receptor alpha in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31886(CD564 | CHEMBL309282)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C26H26O3/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(27)18-7-5-17-14-20(24(28)29)8-6-16(17)13-18/h5-10,13-15H,11-12H2,1-4H3,(H,28,29)
Affinity DataKd:  118nMAssay Description:Apparent binding constant against Retinoic acid receptor alpha in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31886(CD564 | CHEMBL309282)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C26H26O3/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(27)18-7-5-17-14-20(24(28)29)8-6-16(17)13-18/h5-10,13-15H,11-12H2,1-4H3,(H,28,29)
Affinity DataKd:  3nMAssay Description:Apparent binding constant against Retinoic acid receptor gamma in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50051554(6-[2,2-Difluoro-1-(5,5,8,8-tetramethyl-5,6,7,8-tet...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(=C(F)F)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C27H26F2O2/c1-26(2)11-12-27(3,4)22-15-19(9-10-21(22)26)23(24(28)29)18-7-5-17-14-20(25(30)31)8-6-16(17)13-18/h5-10,13-15H,11-12H2,1-4H3,(H,30,31)
Affinity DataKd:  7.5nMAssay Description:Apparent binding constant against Retinoic acid receptor gamma in HeLa cell GAl-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31886(CD564 | CHEMBL309282)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C26H26O3/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(27)18-7-5-17-14-20(24(28)29)8-6-16(17)13-18/h5-10,13-15H,11-12H2,1-4H3,(H,28,29)
Affinity DataKd:  1.20nMAssay Description:Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
Affinity DataKd:  0.400nMAssay Description:Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor beta(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50051551(6-[Hydrazono-(5,5,8,8-tetramethyl-5,6,7,8-tetrahyd...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(N=N)c1ccc2cc(ccc2c1)C(O)=O
Show InChI InChI=1S/C26H28N2O2/c1-25(2)11-12-26(3,4)22-15-19(9-10-21(22)25)23(28-27)18-7-5-17-14-20(24(29)30)8-6-16(17)13-18/h5-10,13-15,23,27H,11-12H2,1-4H3,(H,29,30)
Affinity DataKd:  43nMAssay Description:Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assayMore data for this Ligand-Target Pair