Compile Data Set for Download or QSAR
Found 35 Enz. Inhib. hit(s) with all data for entry = 50029253
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282691(4-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro...)
Show SMILES Cc1cc2c(cc1\C=C\c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-16-14-20-21(24(4,5)13-12-23(20,2)3)15-19(16)11-8-17-6-9-18(10-7-17)22(25)26/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b11-8+
Affinity DataEC50:  1.40nMAssay Description:Transcriptional activation for RAR gamma receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403249(CHEMBL2114394)
Show SMILES C\C(=C\c1ccc(cc1)C(O)=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H30O2/c1-16(13-18-7-9-19(10-8-18)23(26)27)20-15-22-21(14-17(20)2)24(3,4)11-12-25(22,5)6/h7-10,13-15H,11-12H2,1-6H3,(H,26,27)/b16-13-
Affinity DataEC50: >6.40E+3nMAssay Description:Transcriptional activation for RXR alpha receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
Affinity DataEC50:  5nMAssay Description:Transcriptional activation for RAR alpha receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282693(4-[(E)-2-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tet...)
Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1cc2c(cc1Cl)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H27ClO2/c1-15(12-16-6-8-17(9-7-16)22(26)27)18-13-19-20(14-21(18)25)24(4,5)11-10-23(19,2)3/h6-9,12-14H,10-11H2,1-5H3,(H,26,27)/b15-12+
Affinity DataEC50:  275nMAssay Description:Transcriptional activation for RXR alpha receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50032221(4-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro...)
Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H30O2/c1-16(13-18-7-9-19(10-8-18)23(26)27)20-15-22-21(14-17(20)2)24(3,4)11-12-25(22,5)6/h7-10,13-15H,11-12H2,1-6H3,(H,26,27)/b16-13+
Affinity DataEC50:  4.58E+3nMAssay Description:Transcriptional activation for RAR alpha receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
Affinity DataEC50:  0.5nMAssay Description:Transcriptional activation for RAR gamma receptorMore data for this Ligand-Target Pair
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50045276(4-[(E)-1-Methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tet...)
Show SMILES C\C(=C/c1ccc2c(c1)C(C)(C)CCC2(C)C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28O2/c1-16(18-7-9-19(10-8-18)22(25)26)14-17-6-11-20-21(15-17)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+
Affinity DataEC50:  24nMAssay Description:Transcriptional activation for RAR alpha receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM31892(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+
Affinity DataEC50:  3.30nMAssay Description:Transcriptional activation for RAR beta receptorMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282694(4-[(E)-2-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetr...)
Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1cc2c(cc1Br)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H27BrO2/c1-15(12-16-6-8-17(9-7-16)22(26)27)18-13-19-20(14-21(18)25)24(4,5)11-10-23(19,2)3/h6-9,12-14H,10-11H2,1-5H3,(H,26,27)/b15-12+
Affinity DataEC50:  91nMAssay Description:Transcriptional activation for RAR gamma receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282694(4-[(E)-2-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetr...)
Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1cc2c(cc1Br)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H27BrO2/c1-15(12-16-6-8-17(9-7-16)22(26)27)18-13-19-20(14-21(18)25)24(4,5)11-10-23(19,2)3/h6-9,12-14H,10-11H2,1-5H3,(H,26,27)/b15-12+
Affinity DataEC50:  298nMAssay Description:Transcriptional activation for RXR alpha receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50032221(4-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro...)
Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H30O2/c1-16(13-18-7-9-19(10-8-18)23(26)27)20-15-22-21(14-17(20)2)24(3,4)11-12-25(22,5)6/h7-10,13-15H,11-12H2,1-6H3,(H,26,27)/b16-13+
Affinity DataEC50:  74nMAssay Description:Transcriptional activation for RAR beta receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50032219((E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydrona...)
Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+
Affinity DataEC50:  2.40nMAssay Description:Transcriptional activation for RAR gamma receptorMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282693(4-[(E)-2-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tet...)
Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1cc2c(cc1Cl)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H27ClO2/c1-15(12-16-6-8-17(9-7-16)22(26)27)18-13-19-20(14-21(18)25)24(4,5)11-10-23(19,2)3/h6-9,12-14H,10-11H2,1-5H3,(H,26,27)/b15-12+
Affinity DataEC50:  77nMAssay Description:Transcriptional activation for RAR gamma receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282691(4-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro...)
Show SMILES Cc1cc2c(cc1\C=C\c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-16-14-20-21(24(4,5)13-12-23(20,2)3)15-19(16)11-8-17-6-9-18(10-7-17)22(25)26/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b11-8+
Affinity DataEC50:  0.400nMAssay Description:Transcriptional activation for RAR beta receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50032221(4-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro...)
Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H30O2/c1-16(13-18-7-9-19(10-8-18)23(26)27)20-15-22-21(14-17(20)2)24(3,4)11-12-25(22,5)6/h7-10,13-15H,11-12H2,1-6H3,(H,26,27)/b16-13+
Affinity DataEC50:  152nMAssay Description:Transcriptional activation for RAR gamma receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50032219((E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydrona...)
Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+
Affinity DataEC50:  21nMAssay Description:Transcriptional activation for RAR alpha receptorMore data for this Ligand-Target Pair
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
Affinity DataEC50:  1.5nMAssay Description:Transcriptional activation for RAR beta receptorMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282692(4-[(E)-2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-n...)
Show SMILES CC1(C)CCC(C)(C)c2cc(\C=C\c3ccc(cc3)C(O)=O)ccc12
Show InChI InChI=1S/C23H26O2/c1-22(2)13-14-23(3,4)20-15-17(9-12-19(20)22)6-5-16-7-10-18(11-8-16)21(24)25/h5-12,15H,13-14H2,1-4H3,(H,24,25)/b6-5+
Affinity DataEC50:  0.400nMAssay Description:Transcriptional activation for RAR gamma receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282694(4-[(E)-2-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetr...)
Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1cc2c(cc1Br)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H27BrO2/c1-15(12-16-6-8-17(9-7-16)22(26)27)18-13-19-20(14-21(18)25)24(4,5)11-10-23(19,2)3/h6-9,12-14H,10-11H2,1-5H3,(H,26,27)/b15-12+
Affinity DataEC50:  989nMAssay Description:Transcriptional activation for RAR alpha receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282693(4-[(E)-2-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tet...)
Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1cc2c(cc1Cl)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H27ClO2/c1-15(12-16-6-8-17(9-7-16)22(26)27)18-13-19-20(14-21(18)25)24(4,5)11-10-23(19,2)3/h6-9,12-14H,10-11H2,1-5H3,(H,26,27)/b15-12+
Affinity DataEC50: >1.00E+3nMAssay Description:Transcriptional activation for RAR alpha receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50045276(4-[(E)-1-Methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tet...)
Show SMILES C\C(=C/c1ccc2c(c1)C(C)(C)CCC2(C)C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28O2/c1-16(18-7-9-19(10-8-18)22(25)26)14-17-6-11-20-21(15-17)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+
Affinity DataEC50:  0.5nMAssay Description:Transcriptional activation for RAR beta receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50032221(4-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro...)
Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H30O2/c1-16(13-18-7-9-19(10-8-18)23(26)27)20-15-22-21(14-17(20)2)24(3,4)11-12-25(22,5)6/h7-10,13-15H,11-12H2,1-6H3,(H,26,27)/b16-13+
Affinity DataEC50:  385nMAssay Description:Transcriptional activation for RXR alpha receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50044099(4-[(E)-2-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetr...)
Show SMILES CCc1cc2c(cc1\C(C)=C\c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C26H32O2/c1-7-19-15-22-23(26(5,6)13-12-25(22,3)4)16-21(19)17(2)14-18-8-10-20(11-9-18)24(27)28/h8-11,14-16H,7,12-13H2,1-6H3,(H,27,28)/b17-14+
Affinity DataEC50:  195nMAssay Description:Transcriptional activation for RAR gamma receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282691(4-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro...)
Show SMILES Cc1cc2c(cc1\C=C\c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-16-14-20-21(24(4,5)13-12-23(20,2)3)15-19(16)11-8-17-6-9-18(10-7-17)22(25)26/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b11-8+
Affinity DataEC50:  15nMAssay Description:Transcriptional activation for RAR alpha receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50044099(4-[(E)-2-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetr...)
Show SMILES CCc1cc2c(cc1\C(C)=C\c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C26H32O2/c1-7-19-15-22-23(26(5,6)13-12-25(22,3)4)16-21(19)17(2)14-18-8-10-20(11-9-18)24(27)28/h8-11,14-16H,7,12-13H2,1-6H3,(H,27,28)/b17-14+
Affinity DataEC50:  2.22E+3nMAssay Description:Transcriptional activation for RXR alpha receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM31892(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+
Affinity DataEC50:  13nMAssay Description:Transcriptional activation for RXR alpha receptorMore data for this Ligand-Target Pair
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50044099(4-[(E)-2-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetr...)
Show SMILES CCc1cc2c(cc1\C(C)=C\c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C26H32O2/c1-7-19-15-22-23(26(5,6)13-12-25(22,3)4)16-21(19)17(2)14-18-8-10-20(11-9-18)24(27)28/h8-11,14-16H,7,12-13H2,1-6H3,(H,27,28)/b17-14+
Affinity DataEC50:  961nMAssay Description:Transcriptional activation for RAR beta receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50045276(4-[(E)-1-Methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tet...)
Show SMILES C\C(=C/c1ccc2c(c1)C(C)(C)CCC2(C)C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28O2/c1-16(18-7-9-19(10-8-18)22(25)26)14-17-6-11-20-21(15-17)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+
Affinity DataEC50:  0.400nMAssay Description:Transcriptional activation for RAR gamma receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM31892(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+
Affinity DataEC50:  102nMAssay Description:Transcriptional activation for RAR alpha receptorMore data for this Ligand-Target Pair
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50032219((E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydrona...)
Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+
Affinity DataEC50:  4nMAssay Description:Transcriptional activation for RAR beta receptorMore data for this Ligand-Target Pair
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282692(4-[(E)-2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-n...)
Show SMILES CC1(C)CCC(C)(C)c2cc(\C=C\c3ccc(cc3)C(O)=O)ccc12
Show InChI InChI=1S/C23H26O2/c1-22(2)13-14-23(3,4)20-15-17(9-12-19(20)22)6-5-16-7-10-18(11-8-16)21(24)25/h5-12,15H,13-14H2,1-4H3,(H,24,25)/b6-5+
Affinity DataEC50:  0.400nMAssay Description:Transcriptional activation for RAR beta receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282694(4-[(E)-2-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetr...)
Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1cc2c(cc1Br)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H27BrO2/c1-15(12-16-6-8-17(9-7-16)22(26)27)18-13-19-20(14-21(18)25)24(4,5)11-10-23(19,2)3/h6-9,12-14H,10-11H2,1-5H3,(H,26,27)/b15-12+
Affinity DataEC50:  21nMAssay Description:Transcriptional activation for RAR beta receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM31892(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+
Affinity DataEC50:  6nMAssay Description:Transcriptional activation for RAR gamma receptorMore data for this Ligand-Target Pair
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282693(4-[(E)-2-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tet...)
Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1cc2c(cc1Cl)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H27ClO2/c1-15(12-16-6-8-17(9-7-16)22(26)27)18-13-19-20(14-21(18)25)24(4,5)11-10-23(19,2)3/h6-9,12-14H,10-11H2,1-5H3,(H,26,27)/b15-12+
Affinity DataEC50:  21nMAssay Description:Transcriptional activation for RAR beta receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282692(4-[(E)-2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-n...)
Show SMILES CC1(C)CCC(C)(C)c2cc(\C=C\c3ccc(cc3)C(O)=O)ccc12
Show InChI InChI=1S/C23H26O2/c1-22(2)13-14-23(3,4)20-15-17(9-12-19(20)22)6-5-16-7-10-18(11-8-16)21(24)25/h5-12,15H,13-14H2,1-4H3,(H,24,25)/b6-5+
Affinity DataEC50:  11nMAssay Description:Transcriptional activation for RAR alpha receptorMore data for this Ligand-Target Pair
In DepthDetails Article