Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50011820
TargetProstaglandin G/H synthase 1(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 3nMAssay Description:Inhibition of arachidonic acid induced TXB2 generation in isolated human platelets (Prostaglandin G/H synthase 1 cell assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of PGE-2 generation in LPS-stimulated human monocytes (Prostaglandin G/H synthase 2 cell assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 120nMAssay Description:Inhibition of PGE-2 generation in LPS-stimulated human monocytes (Prostaglandin G/H synthase 2 cell assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 210nMAssay Description:Inhibition of PGE-2 generation in LPS-stimulated human monocytes (Prostaglandin G/H synthase 2 cell assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 1(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 230nMAssay Description:Inhibitory effect on Prostaglandin G/H synthase 1 activity was evaluated in human whole blood as TXB2 productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 630nMAssay Description:Inhibitory effect on Prostaglandin G/H synthase 2 activity was evaluated in human whole blood as LPS-induced PGE-2 generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM50110927(1-(4-Chloro-benzyl)-5-methanesulfonyl-1H-indole-2-...)
Affinity DataIC50: 650nMAssay Description:Inhibition of PGE-2 generation in LPS-stimulated human monocytes (Prostaglandin G/H synthase 2 cell assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM50110930(1-(4-Chloro-benzoyl)-5-methanesulfonyl-1H-indole-2...)
Affinity DataIC50: 730nMAssay Description:Inhibitory effect on Prostaglandin G/H synthase 2 activity was evaluated in human whole blood as LPS-induced PGE-2 generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM50110926(5-Methanesulfonyl-1-(4-methoxy-benzyl)-1H-indole-2...)
Affinity DataIC50: 780nMAssay Description:Inhibition of PGE-2 generation in LPS-stimulated human monocytes (Prostaglandin G/H synthase 2 cell assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of arachidonic acid induced TXB2 generation in isolated human platelets (Prostaglandin G/H synthase 1 cell assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibitory effect on Prostaglandin G/H synthase 2 activity was evaluated in human whole blood as LPS-induced PGE-2 generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibitory effect on Prostaglandin G/H synthase 2 activity was evaluated in human whole blood as LPS-induced PGE-2 generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM50110923(1-(4-Bromo-benzyl)-5-methanesulfonyl-1H-indole-2-c...)
Affinity DataIC50: 3.72E+3nMAssay Description:Inhibition of PGE-2 generation in LPS-stimulated human monocytes (Prostaglandin G/H synthase 2 cell assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM50110927(1-(4-Chloro-benzyl)-5-methanesulfonyl-1H-indole-2-...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibitory effect on Prostaglandin G/H synthase 2 activity was evaluated in human whole blood as LPS-induced PGE-2 generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of arachidonic acid induced TXB2 generation in isolated human platelets (Prostaglandin G/H synthase 1 cell assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM50110924(5-Methanesulfonyl-1-(4-nitro-benzyl)-1H-indole-2-c...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PGE-2 generation in LPS-stimulated human monocytes (Prostaglandin G/H synthase 2 cell assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM50110925(5-Methanesulfonyl-1-(4-nitro-benzoyl)-1H-indole-2-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PGE-2 generation in LPS-stimulated human monocytes (Prostaglandin G/H synthase 2 cell assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM50110928(1-(4-Chloro-benzyl)-5-methanesulfonyl-1H-indole-2-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PGE-2 generation in LPS-stimulated human monocytes (Prostaglandin G/H synthase 2 cell assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM50110929(1-(4-Bromo-benzoyl)-5-methanesulfonyl-1H-indole-2-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PGE-2 generation in LPS-stimulated human monocytes (Prostaglandin G/H synthase 2 cell assay)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 2.64E+4nMAssay Description:Inhibitory effect on Prostaglandin G/H synthase 1 activity was evaluated in human whole blood as TXB2 productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 2.87E+4nMAssay Description:Inhibitory effect on Prostaglandin G/H synthase 1 activity was evaluated in human whole blood as TXB2 productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM50110926(5-Methanesulfonyl-1-(4-methoxy-benzyl)-1H-indole-2...)
Affinity DataIC50: 5.13E+4nMAssay Description:Inhibitory effect on Prostaglandin G/H synthase 2 activity was evaluated in human whole blood as LPS-induced PGE-2 generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed