Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50018961
TargetG-protein coupled receptor 52(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50614230(CHEMBL5284353)
Affinity DataEC50:  28nMAssay Description:Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and me...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50614230(CHEMBL5284353)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG by automated patch-clamp assayMore data for this Ligand-Target Pair
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PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50614230(CHEMBL5284353)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Nav1.5 by automated patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 1A2(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50614230(CHEMBL5284353)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2B6(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50614230(CHEMBL5284353)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2C8(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50614230(CHEMBL5284353)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2C9(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50614230(CHEMBL5284353)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2C19(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50614230(CHEMBL5284353)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using s-mephenytoin as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2D6(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50614230(CHEMBL5284353)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 3A4(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50614230(CHEMBL5284353)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 3A4(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50614230(CHEMBL5284353)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed